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Immunology

D-Index
81
Citations
22987
World Ranking
1573
National Ranking
786

Overview

Stephen Gottschalk is affiliated with St. Jude Children's Research Hospital in the United States. Their research spans several interconnected fields, primarily focusing on medicine, biochemistry, genetics, molecular biology, immunology, and microbiology.

Gottschalk's work is centered on oncology, immunology, molecular biology, genetics, and hematology. These subfields reflect their engagement with cancer biology, immune system functioning, gene regulation, and blood-related diseases.

The scientist's main research topics include CAR-T cell therapy research, immune cell function and interaction, virus-based gene therapy research, immunotherapy and immune responses, hematopoietic stem cell transplantation, viral infectious diseases and gene expression in insects, and nanowire synthesis and applications.

Key recent papers authored or co-authored by Gottschalk include:

  • CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality? (2020) in Molecular Therapy
  • Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity (2021) in Science Translational Medicine
  • CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity (2021) in Blood
  • RASA2 ablation in T cells boosts antigen sensitivity and long-term function (2022) in Nature
  • Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma (2020) in Nature Communications

Gottschalk frequently publishes in the following venues:

  • Blood
  • Transplantation and Cellular Therapy
  • Neuro-Oncology
  • Cytotherapy
  • Regular and Young Investigator Award Abstracts

The scientist has collaborated regularly with co-authors including Aimee C. Talleur, Brandon M. Triplett, Swati Naik, Giedre Krenciute, and Mireya Paulina Velasquez. These collaborations indicate active engagement with peers to advance their fields of study.

Best Publications

  • Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

    Nabil Ahmed;Vita S. Brawley;Meenakshi Hegde;Catherine Robertson

  • HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial

    Nabil Ahmed;Nabil Ahmed;Vita Brawley;Vita Brawley;Meenakshi Hegde;Meenakshi Hegde;Kevin Bielamowicz

  • Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

    Meenakshi Hegde;Malini Mukherjee;Malini Mukherjee;Zakaria Grada;Antonella Pignata

  • Design and development of therapies using chimeric antigen receptor-expressing T cells

    Gianpietro Dotti;Stephen Gottschalk;Barbara Savoldo;Malcolm K. Brenner

  • Post-transplant lymphoproliferative disorders.

    Stephen Gottschalk;Cliona M. Rooney;Helen E. Heslop

  • Sustained Complete Responses in Patients With Lymphoma Receiving Autologous Cytotoxic T Lymphocytes Targeting Epstein-Barr Virus Latent Membrane Proteins

    Catherine M. Bollard;Catherine M. Bollard;Stephen Gottschalk;Stephen Gottschalk;Vicky Torrano;Vicky Torrano;Oumar Diouf;Oumar Diouf

  • TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

    Zakaria Grada;Zakaria Grada;Meenakshi Hegde;Meenakshi Hegde;Tiara Byrd;Tiara Byrd;Donald R Shaffer;Donald R Shaffer

  • Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation

    Ifigeneia Tzannou;Anastasia Papadopoulou;Swati Naik;Kathryn Leung

  • HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors

    Nabil Ahmed;Vita S. Salsman;Yvonne Kew;Donald Shaffer

  • A novel DNA-peptide complex for efficient gene transfer and expression in mammalian cells.

    S. Gottschalk;J. T. Sparrow;J. Hauer;M. P. Mims

  • Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States

    Jeffrey I. Cohen;Elaine S. Jaffe;Janet K. Dale;Stefania Pittaluga

  • Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma

    Sunitha Kakarla;Kevin K H Chow;Kevin K H Chow;Melinda Mata;Melinda Mata;Donald R Shaffer;Donald R Shaffer

  • CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?

    Jessica Wagner;Elizabeth Wickman;Christopher DeRenzo;Stephen Gottschalk

  • Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer.

    Catherine M. Bollard;Stephen Gottschalk;Ann M. Leen;Heidi Weiss

  • An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs

    Stephen Gottschalk;Catherine Y. C. Ng;Margot Perez;Colton A. Smith

  • Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs).

    Barbara Savoldo;John A. Goss;John A. Goss;Markus M. Hammer;Markus M. Hammer;Lan Zhang;Lan Zhang

  • Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity.

    Brooke Prinzing;Caitlin C. Zebley;Christopher T. Petersen;Yiping Fan

  • Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants.

    Giedre Krenciute;Giedre Krenciute;Brooke L. Prinzing;Zhongzhen Yi;Zhongzhen Yi;Meng Fen Wu

  • Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells

    Thomas Shum;Thomas Shum;Bilal Omer;Bilal Omer;Haruko Tashiro;Robert L. Kruse;Robert L. Kruse

  • T cells redirected to EphA2 for the immunotherapy of glioblastoma.

    Kevin Kh Chow;Swati Naik;Sunitha Kakarla;Vita S. Brawley

  • Rapidly Generated Multivirus-specific Cytotoxic T Lymphocytes for the Prophylaxis and Treatment of Viral Infections

    Ulrike Gerdemann;Jacqueline M Keirnan;Usha L Katari;Ryu Yanagisawa

  • Adoptive T-cell transfer and chemotherapy in the first-line treatment of metastatic and/or locally recurrent nasopharyngeal carcinoma.

    Whay-Kuang Chia;Marissa Teo;Who-Whong Wang;Bernett Lee

Frequent Co-Authors

Helen E. Heslop
Helen E. Heslop Baylor College of Medicine
Malcolm K. Brenner
Malcolm K. Brenner Baylor College of Medicine
Cliona M. Rooney
Cliona M. Rooney Baylor College of Medicine
Catherine M. Bollard
Catherine M. Bollard George Washington University
Gianpietro Dotti
Gianpietro Dotti University of North Carolina at Chapel Hill
Adrian P. Gee
Adrian P. Gee Baylor College of Medicine
Ann M. Leen
Ann M. Leen Baylor College of Medicine
Hao Liu
Hao Liu Indiana University
Winfried S. Wels
Winfried S. Wels Goethe University Frankfurt
Barbara Savoldo
Barbara Savoldo University of North Carolina at Chapel Hill

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