Martin Citron

Overview

Best Publications

• Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

  Robert Vassar;Brian D. Bennett;Safura Babu-Khan;Steve Kahn

  5064
  Citations

• Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

  D. Scheuner;C. Eckman;C. Eckman;M. Jensen;X. Song

  4221
  Citations

• Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

  Martin Citron;Tilman Oltersdorf;Christian Haass;Lisa McConlogue

  2528
  Citations

• Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

  Martin Citron;David Westaway;Weiming Xia;George Carlson

  1800
  Citations

• Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.

  Yi Luo;Brad Bolon;Steve Kahn;Brian D. Bennett

  1383
  Citations

• Alzheimer's disease: strategies for disease modification

  Martin Citron

  1310
  Citations

• Control of peripheral nerve myelination by the beta-secretase BACE1.

  Michael Willem;Alistair N. Garratt;Bozidar Novak;Martin Citron

  900
  Citations

• Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.

  Li Bang Yang;Kristina Lindholm;Riqiang Yan;Martin Citron

  899
  Citations

• Both Familial Parkinson’s Disease Mutations Accelerate α-Synuclein Aggregation

  Linda Narhi;Stephen J. Wood;Shirley Steavenson;Yijia Jiang

  895
  Citations

• alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease.

  Stephen J. Wood;Jette Wypych;Shirley Steavenson;Jean-Claude Louis

  856
  Citations

• The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.

  Christian Haass;Cynthia A. Lemere;Anja Capell;Anja Capell;Martin Citron

  806
  Citations

• BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

  Masuo Ohno;Evgeny A Sametsky;Linda H Younkin;Holly Oakley

  711
  Citations

• Strategies for disease modification in Alzheimer's disease

  Martin Citron

  669
  Citations

• Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease

  Qiao Yan;Jianhua Zhang;Hantao Liu;Safura Babu-Khan

  653
  Citations

• Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients

  Rena Li;Kristina Lindholm;Li-Bang Yang;Xu Yue

  644
  Citations

• Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor

  P. C. May;R. A. Dean;S. L. Lowe;F. Martenyi

  524
  Citations

• Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

  A. Y. Hung;C. Haass;R. M. Nitsch;Wei Qiao Qiu

  510
  Citations

• Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

  Martin Citron;Carmen Vigo-Pelfrey;David B. Teplow;Christine Miller

  481
  Citations

• The Proteolytic Fragments of the Alzheimer’s Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

  Anja Capell;Jürgen Grünberg;Brigitte Pesold;Anke Diehlmann

  443
  Citations

• Expression analysis of BACE2 in brain and peripheral tissues.

  Brian D. Bennett;Safura Babu-Khan;Richard Loeloff;Jean Claude Louis

  440
  Citations