World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
112
Citations
54127
World Ranking
503
National Ranking
296

Biology and Biochemistry

D-Index
113
Citations
55653
World Ranking
848
National Ranking
531

Research.com Recognitions

  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1997 - Sedgwick Memorial Medal, American Public Health Association
  • 1997 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 1997 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

Overview

Sangram S. Sisodia is affiliated with the University of Chicago in the United States. Their research spans multiple fields, primarily focusing on neuroscience, biochemistry, genetics, molecular biology, and medicine. Within these disciplines, their specific subfields of study include molecular biology, physiology, biological psychiatry, neurology, and immunology.

The scientist's research addresses several key topics, including:

  • Gut microbiota and health
  • Tryptophan and brain disorders
  • Alzheimer's disease research and treatments
  • Neuroinflammation and neurodegeneration mechanisms
  • Diet and metabolism studies
  • Lipid membrane structure and behavior
  • Neuroscience and neuropharmacology research

Among the recent papers contributed by Sangram S. Sisodia are:

  • The gut microbiome in Alzheimer's disease: what we know and what remains to be explored (2023, Molecular Neurodegeneration)
  • ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy (2023, Science)
  • Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia (2021, The Journal of Experimental Medicine)
  • Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice (2020, Scientific Reports)
  • DNA-based fluorescent probes of NOS2 activity in live brains (2020, Proceedings of the National Academy of Sciences)

Their frequent co-authors include:

  • Hemraj B. Dodiya
  • Ian Q. Weigle
  • Rudolph E. Tanzi
  • Can Zhang
  • Xiaoqiong Zhang

Publication venues where Sangram S. Sisodia has contributed multiple works are:

  • Molecular Neurodegeneration
  • Alzheimer s & Dementia
  • Scientific Reports
  • Neurotherapeutics
  • The Journal of Experimental Medicine

Throughout their career, Sangram S. Sisodia has received several awards, including:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2008
  • Sedgwick Memorial Medal, American Public Health Association, 1997
  • Metlife Foundation Award for Medical Research in Alzheimer's Disease, 1997
  • Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology, 1997

Best Publications

  • APP processing and synaptic function.

    Flavio Kamenetz;Taisuke Tomita;Helen Hsieh;Helen Hsieh;Guy Seabrook

  • Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

    David R. Borchelt;Gopal Thinakaran;Christopher B. Eckman;Christopher B. Eckman;Michael K. Lee

  • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

    Philip C Wong;Carlos A Pardo;David R Borchelt;Michael K Lee

  • ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

    L. I. Bruijn;M. W. Becher;M. K. Lee;K. L. Anderson

  • Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

    David R Borchelt;Tamara Ratovitski;Judy van Lare;Michael K Lee

  • AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.

    Helen Hsieh;Jannic Boehm;Chihiro Sato;Takeshi Iwatsubo

  • ENDOPROTEOLYSIS OF PRESENILIN 1 AND ACCUMULATION OF PROCESSED DERIVATIVES IN VIVO

    Gopal Thinakaran;David R Borchelt;Michael K Lee;Hilda H Slunt

  • Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.

    S. S. Sisodia;E. H. Koo;K. Beyreuther;A. Unterbeck

  • Trafficking and Proteolytic Processing of APP

    Christian Haass;Christoph Kaether;Gopal Thinakaran;Sangram Sisodia

  • Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

    Orly Lazarov;John Robinson;Ya Ping Tang;Ilana S. Hairston

  • A mouse model for Down syndrome exhibits learning and behaviour deficits

    Roger H. Reeves;Nicholas G. Irving;Timothy H. Moran;Anny Wohn

  • Beta-amyloid precursor protein cleavage by a membrane-bound protease.

    Sangram S. Sisodia

  • Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

    Edward H. Koo;Sangram S. Sisodia;David R. Archer;Lee J. Martin

  • β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

    Hui Zheng;Minghao Jiang;Myrna E. Trumbauer;Dalip J.S. Sirinathsinghji

  • Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

    Philip C. Wong;Hui Zheng;Hua Chen;Mark W. Becher

  • MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

    Donald L. Price;Sangram S. Sisodia

  • Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

    David R. Borchelt;Michael K. Lee;Hilda S. Slunt;Michael Guarnieri

  • Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

    Marco Prinz;Josef Priller;Sangram S Sisodia;Richard M Ransohoff

  • γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

    Sangram S. Sisodia;Peter H. St George-Hyslop

  • Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

    Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent

Frequent Co-Authors

Donald L. Price
Donald L. Price Johns Hopkins University
Gopal Thinakaran
Gopal Thinakaran University of Chicago
David R. Borchelt
David R. Borchelt University of Florida
Don W. Cleveland
Don W. Cleveland University of California, San Diego
Lee J. Martin
Lee J. Martin Johns Hopkins University School of Medicine
Rong Wang
Rong Wang Icahn School of Medicine at Mount Sinai
Rudolph E. Tanzi
Rudolph E. Tanzi Harvard University
Philip C. Wong
Philip C. Wong Johns Hopkins University School of Medicine
Lary C. Walker
Lary C. Walker Emory University
Vassilis E. Koliatsos
Vassilis E. Koliatsos Johns Hopkins University School of Medicine

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