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Biology and Biochemistry

D-Index
98
Citations
48495
World Ranking
1627
National Ranking
907

Overview

David R. Borchelt is affiliated with the University of Florida in the United States. Their research primarily focuses on the fields of medicine, neuroscience, and biochemistry, genetics, and molecular biology. Within these broad domains, their work delves into subfields including neurology, physiology, molecular biology, cellular and molecular neuroscience, and pharmacology.

The main topics addressed in their research include:

  • Alzheimer's disease research and treatments
  • Prion diseases and protein misfolding
  • Amyotrophic lateral sclerosis research
  • Neuroinflammation and neurodegeneration mechanisms
  • Cholinesterase and neurodegenerative diseases
  • Neurogenetic and muscular disorders research
  • Parkinson's disease mechanisms and treatments

David R. Borchelt has published multiple papers in a variety of scientific venues. Some recent papers include:

  • "Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease" (2020), published in Molecular Neurodegeneration
  • "Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model" (2021), published in Glia
  • "Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis" (2022), published in Molecular Neurodegeneration
  • "Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection" (2020), published in PLoS ONE
  • "Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer's disease" (2024), published in Cell Reports Medicine

The scientist collaborates frequently with other researchers, including:

  • Paramita Chakrabarty
  • Guilian Xu
  • Susan Fromholt
  • Benoit I. Giasson
  • Stefan Prokop

David R. Borchelt's work has been published often in several scientific venues, particularly:

  • Acta Neuropathologica Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Neurodegeneration
  • Alzheimer s & Dementia
  • Glia

Best Publications

  • APP processing and synaptic function.

    Flavio Kamenetz;Taisuke Tomita;Helen Hsieh;Helen Hsieh;Guy Seabrook

  • Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

    David R. Borchelt;Gopal Thinakaran;Christopher B. Eckman;Christopher B. Eckman;Michael K. Lee

  • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

    Philip C Wong;Carlos A Pardo;David R Borchelt;Michael K Lee

  • Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

    Joanna L. Jankowsky;Joanna L. Jankowsky;Daniel J. Fadale;Jeffrey Anderson;Guilian M. Xu

  • ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

    L. I. Bruijn;M. W. Becher;M. K. Lee;K. L. Anderson

  • BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.

    Huaibin Cai;Yanshu Wang;Diane McCarthy;Hongjin Wen

  • Scrapie prion protein contains a phosphatidylinositol glycolipid

    Neil Stahl;David R. Borchelt;Karen Hsiao;Stanley B. Prusiner

  • Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

    David R Borchelt;Tamara Ratovitski;Judy van Lare;Michael K Lee

  • ENDOPROTEOLYSIS OF PRESENILIN 1 AND ACCUMULATION OF PROCESSED DERIVATIVES IN VIVO

    Gopal Thinakaran;David R Borchelt;Michael K Lee;Hilda H Slunt

  • Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide

    Daniel Krewski;Robert A Yokel;Evert Nieboer;David Borchelt

  • Intranuclear Inclusions and Neuritic Aggregates in Transgenic Mice Expressing a Mutant N-Terminal Fragment of Huntingtin

    Gabriele Schilling;Mark W. Becher;Alan H. Sharp;Hyder A. Jinnah

  • Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

    Joanna L Jankowsky;Hilda H Slunt;Tamara Ratovitski;Nancy A Jenkins

  • Decreased expression of striatal signaling genes in a mouse model of Huntington’s disease

    Ruth Luthi-Carter;Andrew Strand;Nikki L. Peters;Steven M. Solano

  • Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

    David R. Borchelt;Michael K. Lee;Hilda S. Slunt;Michael Guarnieri

  • Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

    David R. Borchelt;Michael Scott;Albert Taraboulos;Neff Stahl

  • BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

    Fiona M. Laird;Huaibin Cai;Alena V. Savonenko;Mohamed H. Farah

  • Age-Related CNS Disorder and Early Death in Transgenic FVB/N Mice Overexpressing Alzheimer Amyloid Precursor Proteins

    Karen K. Hsiao;David R. Borchelt;Kristine Olson;Rosa Johannsdottir

  • Evidence for synthesis of scrapie prion proteins in the endocytic pathway.

    D R Borchelt;A Taraboulos;S B Prusiner

  • Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease.

    Joanna L. Jankowsky;Joanna L. Jankowsky;Tatiana Melnikova;Daniel J. Fadale;Guilian M. Xu

  • Alzheimer's disease: genetic studies and transgenic models.

    Donald L. Price;Rudolph E. Tanzi;David R. Borchelt;Sangram S. Sisodia

Frequent Co-Authors

Donald L. Price
Donald L. Price Johns Hopkins University
Sangram S. Sisodia
Sangram S. Sisodia University of Chicago
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Philip C. Wong
Philip C. Wong Johns Hopkins University School of Medicine
Todd E. Golde
Todd E. Golde Emory University
Christopher A. Ross
Christopher A. Ross Johns Hopkins University School of Medicine
Gopal Thinakaran
Gopal Thinakaran University of Chicago
Alena Savonenko
Alena Savonenko Johns Hopkins University School of Medicine
Don W. Cleveland
Don W. Cleveland University of California, San Diego

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