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193
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Biology and Biochemistry

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194
Citations
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Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2009 - US President's National Medal of Science "For his discovery of prions, the causative agent of bovine spongiform encephalopathy and other related neurodegenerative diseases, and his continuing efforts to develop effective methods for detecting and treating prion diseases. ", Presented by President Barack H. Obama in the East Room of the White House on November 17, 2010.
  • 1998 - Benjamin Franklin Medal, Franklin Institute
  • 1997 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1997 - Nobel Prize for his discovery of Prions - a new biological principle of infection
  • 1997 - Fellow of the Royal Society, United Kingdom
  • 1997 - Louisa Gross Horwitz Prize, Columbia University
  • 1996 - Keio Medical Science Prize, Keio University, Tokyo, Japan
  • 1995 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 1995 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 1994 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 1993 - Fellow of the American Academy of Arts and Sciences
  • 1993 - Canada Gairdner International Award
  • 1992 - Member of the National Academy of Medicine (NAM)
  • 1992 - Member of the National Academy of Sciences
  • 1991 - Sedgwick Memorial Medal, American Public Health Association
  • 1991 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 1991 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
  • 1976 - Fellow of Alfred P. Sloan Foundation

Overview

Stanley B. Prusiner is affiliated with the University of California, San Francisco in the United States. Their research mainly centers on biochemistry, genetics, and molecular biology, with a significant focus on molecular biology, neurology, physiology, biophysics, and computational theory and mathematics as subfields. The scientist's work covers a range of topics including Alzheimer's disease research and treatments, prion diseases and protein misfolding, neurological diseases and metabolism, Parkinson's disease mechanisms and treatments, RNA regulation and disease, cell image analysis techniques, and computational drug discovery methods.

Their recent publications span various high-profile journals and research themes. These include:

  • Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components, 2021, Neuron
  • Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy, 2022, Proceedings of the National Academy of Sciences
  • Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments, 2023, Nature Communications
  • How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders, 2021, International Journal of Molecular Sciences
  • Expanding spectrum of prion diseases, 2020, Emerging Topics in Life Sciences

Frequent coauthors collaborating with Stanley B. Prusiner include Hooman Kamel, New York, Dena B. Dubal, San Francisco, and Bernard Chang.

The researcher commonly publishes in the following venues:

  • JAMA Neurology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Acta Neuropathologica
  • Neuron

Their career includes multiple awards and honors, such as the Nobel Prize in 1997 for the discovery of prions as a new biological principle of infection. Other recognitions include the US President's National Medal of Science awarded in 2009, the Benjamin Franklin Medal from the Franklin Institute in 1998, the Louisa Gross Horwitz Prize from Columbia University in 1997, and fellowships in prestigious societies like the Royal Society in the United Kingdom and the American Association for the Advancement of Science.

Additional distinctions consist of the Keio Medical Science Prize in Tokyo, the Paul Ehrlich and Ludwig Darmstaedter Prize in 1995, the Albert Lasker Award for Basic Medical Research in 1994, and memberships in the National Academy of Sciences and National Academy of Medicine since 1992, among others.

Best Publications

  • Nobel Lecture: Prions

    S. B. Prusiner

  • Novel proteinaceous infectious particles cause scrapie

    Stanley B. Prusiner

  • Molecular biology of prion diseases

    Stanley B. Prusiner

  • Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

    Hansruedi Büeler;Marek Fischer;Yolande Lang;Yolande Lang;Horst Bluethmann;Horst Bluethmann

  • A cellular gene encodes scrapie PrP 27-30 protein

    Bruno Oesch;Bruno Oesch;David Westaway;Monika Wälchli;Monika Wälchli;Michael P. McKinley

  • Identification of a protein that purifies with the scrapie prion.

    David C. Bolton;Michael P. McKinley;Stanley B. Prusiner

  • Eight prion strains have PrP Sc molecules with different conformations

    Jiri Safar;Holger Wille;Vincenza Itri;Darlene Groth

  • Scrapie prions aggregate to form amyloid-like birefringent rods

    Stanley B. Prusiner;Michael P. McKinley;Karen A. Bowman;David C. Bolton

  • Scrapie prion protein contains a phosphatidylinositol glycolipid

    Neil Stahl;David R. Borchelt;Karen Hsiao;Stanley B. Prusiner

  • Prion Diseases and the BSE Crisis

    Stanley B. Prusiner

  • A protease-resistant protein is a structural component of the Scrapie prion

    Michael P. McKinley;David C. Bolton;Stanley B. Prusiner

  • Synthetic Mammalian Prions

    Giuseppe Legname;Ilia V. Baskakov;Hoang-Oanh B. Nguyen;Detlev Riesner

  • Prion protein biology.

    Stanley B Prusiner;Michael R Scott;Stephen J DeArmond;Fred E Cohen

  • Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

    K. Basler;B. Oesch;M. Scott;D. Westaway

  • Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

    Stanley B. Prusiner;Michael Scott;Dallas Foster;Keh-Ming Pan

  • Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

    Glenn C. Telling;Michael Scott;James Mastrianni;Ruth Gabizon

  • Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome

    Karen Hsiao;Harry F. Baker;Tim J. Crow;Mark Poulter

  • Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

    Glenn C. Telling;Piero Parchi;Stephen J. DeArmond;Pietro Cortelli

  • Shattuck lecture--neurodegenerative diseases and prions.

    Stanley B. Prusiner

  • Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

    Michael Scott;Dallas Foster;Carol Mirenda;Dan Serban

Frequent Co-Authors

Stephen J. DeArmond
Stephen J. DeArmond University of California, San Francisco
Darlene Groth
Darlene Groth University of California, San Francisco
Fred E. Cohen
Fred E. Cohen University of California, San Francisco
Holger Wille
Holger Wille University of Alberta
Giuseppe Legname
Giuseppe Legname International School for Advanced Studies
Michael A. Baldwin
Michael A. Baldwin University of California, San Francisco
Frederick Cohen
Frederick Cohen Nurix Therapeutics
George A. Carlson
George A. Carlson University of California, San Francisco
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Leroy Hood
Leroy Hood University of Washington

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