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Chemistry

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46
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15970
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3988

Biology and Biochemistry

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Overview

Ilia V. Baskakov is affiliated with the University of Maryland, Baltimore in the United States. Their research primarily focuses on the fields of neuroscience as well as biochemistry, genetics, and molecular biology, with a significant number of publications in these areas. More specifically, their work spans subfields such as neurology, molecular biology, physiology, biological psychiatry, and cellular and molecular neuroscience.

The main research topics covered by Baskakov include prion diseases and protein misfolding, neuroinflammation and neurodegeneration mechanisms, Alzheimer's disease research and treatments, tryptophan and brain disorders, neurological diseases and metabolism, RNA regulation and disease, and neurogenesis and neuroplasticity mechanisms.

Baskakov has contributed extensively to the scientific literature, with frequent publications in venues including bioRxiv (Cold Spring Harbor Laboratory), Acta Neuropathologica Communications, the Journal of Clinical Investigation, Neurobiology of Disease, and Cells.

Recent publications by Baskakov include:

  • Region-specific glial homeostatic signature in prion diseases is replaced by a uniform neuroinflammation signature, common for brain regions and prion strains with different cell tropism (2020, Neurobiology of Disease)
  • The degree of astrocyte activation is predictive of the incubation time to prion disease (2021, Acta Neuropathologica Communications)
  • Posttranslational modifications define course of prion strain adaptation and disease phenotype (2020, Journal of Clinical Investigation)
  • Phagocytic Activities of Reactive Microglia and Astrocytes Associated with Prion Diseases Are Dysregulated in Opposite Directions (2021, Cells)
  • Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases (2021, Acta Neuropathologica Communications)

Baskakov frequently collaborates with a number of coauthors, including:

  • Natallia Makarava
  • Kara Molesworth
  • Narayan Pandit
  • Olga V. Bocharova
  • Olga Mychko

Best Publications

  • Synthetic Mammalian Prions

    Giuseppe Legname;Ilia V. Baskakov;Hoang-Oanh B. Nguyen;Detlev Riesner

  • The osmophobic effect: natural selection of a thermodynamic force in protein folding.

    D.W Bolen;Ilia V Baskakov

  • Pathway complexity of prion protein assembly into amyloid.

    Ilia V. Baskakov;Giuseppe Legname;Michael A. Baldwin;Stanley B. Prusiner

  • Forcing Thermodynamically Unfolded Proteins to Fold

    Ilia Baskakov;D. Wayne Bolen

  • Recombinant prion protein induces a new transmissible prion disease in wild-type animals

    Natallia Makarava;Gabor G. Kovacs;Olga Bocharova;Regina Savtchenko

  • In vitro Conversion of Full-length Mammalian Prion Protein Produces Amyloid Form with Physical Properties of PrPSc

    Olga V. Bocharova;Leonid Breydo;Alexander S. Parfenov;Vadim V. Salnikov

  • Light-Dependent Electrogenic Activity of Cyanobacteria

    John M. Pisciotta;Yongjin Zou;Ilia V. Baskakov

  • Amyloid fibrils of mammalian prion protein are highly toxic to cultured cells and primary neurons.

    Vera Novitskaya;Olga V. Bocharova;Igor Bronstein;Ilia V. Baskakov;Ilia V. Baskakov

  • Folding of Prion Protein to Its Native α-Helical Conformation Is under Kinetic Control

    Ilia V. Baskakov;Giuseppe Legname;Stanley B. Prusiner;Fred E. Cohen

  • Design and construction of diverse mammalian prion strains.

    David W. Colby;Kurt Giles;Giuseppe Legname;Holger Wille

  • Strain-specified characteristics of mouse synthetic prions

    Giuseppe Legname;Hoang-Oanh B. Nguyen;Ilia V. Baskakov;Fred E. Cohen

  • Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils.

    Olga V. Bocharova;Leonid Breydo;Vadim V. Salnikov;Ilia V. Baskakov

  • Photosynthetic microbial fuel cells with positive light response

    Yongjin Zou;John Pisciotta;R. Blake Billmyre;R. Blake Billmyre;Ilia V. Baskakov

  • Protease-Sensitive Synthetic Prions

    David W. Colby;Rachel Wain;Ilia V. Baskakov;Giuseppe Legname

  • Trimethylamine N-Oxide-induced Cooperative Folding of an Intrinsically Unfolded Transcription-activating Fragment of Human Glucocorticoid Receptor

    Ilia V. Baskakov;Raj Kumar;Ganesan Srinivasan;Yan-shan Ji

  • The α-helical C-terminal domain of full-length recombinant PrP converts to an in-register parallel β-sheet structure in PrP fibrils: evidence from solid state nuclear magnetic resonance.

    Robert Tycko;Regina Savtchenko;Valeriy G. Ostapchenko;Natallia Makarava

  • Trimethylamine-N-oxide counteracts urea effects on rabbit muscle lactate dehydrogenase function: a test of the counteraction hypothesis.

    Ilia Baskakov;Aijun Wang;D.W. Bolen

  • Polymorphism and ultrastructural organization of prion protein amyloid fibrils: an insight from high resolution atomic force microscopy.

    Maighdlin Anderson;Olga V. Bocharova;Natallia Makarava;Leonid Breydo

  • Highly Efficient Protein Misfolding Cyclic Amplification

    Nuria Gonzalez-Montalban;Natallia Makarava;Valeriy G. Ostapchenko;Regina Savtchenk

  • The Same Primary Structure of the Prion Protein Yields Two Distinct Self-propagating States

    Natallia Makarava;Ilia V. Baskakov

  • Interdomain signaling in a two-domain fragment of the human glucocorticoid receptor.

    Raj Kumar;Ilia V. Baskakov;Ganesan Srinivasan;David W. Bolen

Frequent Co-Authors

Stanley B. Prusiner
Stanley B. Prusiner University of California, San Francisco
Giuseppe Legname
Giuseppe Legname International School for Advanced Studies
Gabor G. Kovacs
Gabor G. Kovacs University of Toronto
Stephen J. DeArmond
Stephen J. DeArmond University of California, San Francisco
Fred E. Cohen
Fred E. Cohen University of California, San Francisco
Yongjin Zou
Yongjin Zou Guilin University of Electronic Technology
Herbert Budka
Herbert Budka Medical University of Vienna
Holger Wille
Holger Wille University of Alberta
Lai-Xi Wang
Lai-Xi Wang University of Maryland, College Park
Claudio Soto
Claudio Soto The University of Texas Health Science Center at Houston

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