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Joaquín Castilla

Joaquín Castilla

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
10356
World Ranking
18290
National Ranking
417

Overview

Joaquín Castilla is affiliated with Ikerbasque in Spain and has a research focus primarily in biochemistry, genetics, and molecular biology. Their work predominantly explores molecular biology with a significant presence in neurology and nutrition and dietetics. The research also extends into infectious diseases and ecology, reflecting a multidisciplinary approach within life sciences.

The scientist's research topics cover a range of biomedical and molecular fields including prion diseases and protein misfolding, neurological diseases and metabolism, trace elements in health, RNA regulation and disease, as well as alcoholism and thiamine deficiency. Their studies also address infectious encephalopathies and encephalitis, alongside animal disease management and epidemiology.

Joaquín Castilla has published extensively on prion diseases and related neurodegenerative conditions. Some of the recent papers include:

  • Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein (2020), published in The FASEB Journal
  • Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear (2021), published in Scientific Reports
  • Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases (2021), published in International Journal of Molecular Sciences
  • Prion-Associated Neurodegeneration Causes Both Endoplasmic Reticulum Stress and Proteasome Impairment in a Murine Model of Spontaneous Disease (2021), published in International Journal of Molecular Sciences
  • Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation (2023), published in Acta Neuropathologica Communications

Their research outputs have appeared frequently in journals such as bioRxiv (Cold Spring Harbor Laboratory), PLoS Pathogens, International Journal of Molecular Sciences, Acta Neuropathologica Communications, and iScience.

Joaquín Castilla collaborates regularly with a core group of coauthors including Hasier Eraña, Jorge M. Charco, Carlos M. Díaz-Domínguez, Miguel A. Pérez-Castro, and Jesús R. Requena. These collaborations reflect ongoing partnerships within their research network especially in the field of prion and neurodegenerative disease studies.

Best Publications

  • In Vitro Generation of Infectious Scrapie Prions

    Joaquín Castilla;Paula Saá;Paula Saá;Claudio Hetz;Claudio Hetz;Claudio Soto

  • Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

    Claudio Hetz;Milene Russelakis‐Carneiro;Kinsey Maundrell;Joaquin Castilla

  • Production of cattle lacking prion protein.

    Jiirgen A. Richt;Poothappillai Kasinathan;Amir N. Hamir;Joaquin Castilla

  • Detection of prions in blood

    Joaquín Castilla;Paula Saá;Paula Saá;Claudio Soto

  • Ultra-efficient Replication of Infectious Prions by Automated Protein Misfolding Cyclic Amplification

    Paula Saá;Paula Saá;Joaquín Castilla;Claudio Soto

  • Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

    Claudio Soto;Lisbell Estrada;Joaquín Castilla

  • Presymptomatic Detection of Prions in Blood

    Paula Saá;Joaquín Castilla;Claudio Soto

  • The Disulfide Isomerase Grp58 Is a Protective Factor against Prion Neurotoxicity

    Claudio Hetz;Claudio Hetz;Milene Russelakis-Carneiro;Sébastien Wälchli;Sonia Carboni

  • Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure

    Rachel C. Angers;Hae-Eun Kang;Dana Napier;Shawn Browning

  • Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality

    Jatish Kumar;Hasier Eraña;Elena López-Martínez;Nathalie Claes

  • De novo induction of amyloid-β deposition in vivo.

    R Morales;C Duran-Aniotz;C Duran-Aniotz;J Castilla;J Castilla;L D Estrada;L D Estrada

  • Cell-free propagation of prion strains

    Joaquín Castilla;Rodrigo Morales;Rodrigo Morales;Paula Saá;Paula Saá;Marcelo Barria

  • Crossing the species barrier by PrPSc replication in vitro generates unique infectious Prions

    Joaquín Castilla;Dennisse Gonzalez-Romero;Paula Saá;Paula Saá;Rodrigo Morales;Rodrigo Morales

  • Molecular Cross-talk between Misfolded Proteins in Animal Models of Alzheimer’s and Prion Diseases

    Rodrigo Morales;Lisbell D. Estrada;Lisbell D. Estrada;Rodrigo Diaz-Espinoza;Rodrigo Diaz-Espinoza;Diego Morales-Scheihing

  • Pre-symptomatic detection of prions by cyclic amplification of protein misfolding

    Claudio Soto;Laurence Anderes;Silvia Suardi;Franco Cardone

  • Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis

    Claudio Hetz;Ann-Hwee Lee;Dennisse Gonzalez-Romero;Peter Thielen

  • Protein Misfolding Cyclic Amplification for Diagnosis and Prion Propagation Studies

    Joaquín Castilla;Paula Saá;Rodrigo Morales;Karim Abid

  • Isolation and characterization of a proteinase K-sensitive PrPSc fraction.

    Miguel A. Pastrana;Gustavo Sajnani;Bruce Onisko;Joaquin Castilla

  • Early detection of PrPres in BSE-infected bovine PrP transgenic mice.

    J Castilla;A Gutiérrez Adán;A Brun;B Pintado

  • A molecular switch controls interspecies prion disease transmission in mice

    Christina J. Sigurdson;K. Peter R. Nilsson;K. Peter R. Nilsson;Simone Hornemann;Simone Hornemann;Giuseppe Manco

Frequent Co-Authors

Claudio Soto
Claudio Soto The University of Texas Health Science Center at Houston
Christina J. Sigurdson
Christina J. Sigurdson University of California, San Diego
Claudio Hetz
Claudio Hetz University of Chile
Olivier Andreoletti
Olivier Andreoletti École Nationale Vétérinaire de Toulouse
Luis Enjuanes
Luis Enjuanes Spanish National Research Council
Adriano Aguzzi
Adriano Aguzzi University of Zurich
Isabel Sola
Isabel Sola Spanish National Research Council
Alfonso Gutiérrez-Adán
Alfonso Gutiérrez-Adán Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
Kurt Wüthrich
Kurt Wüthrich ETH Zurich
K. Peter R. Nilsson
K. Peter R. Nilsson Linköping University

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