World's Best Scientists 2026 revealed!
Joaquín Castilla

Joaquín Castilla

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
10356
World Ranking
18290
National Ranking
417

Joaquín Castilla publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Joaquín Castilla sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 137 publications — 20th percentile

20% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Joaquín Castilla D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Joaquín Castilla sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 48 D-Index — 7th percentile

7% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Joaquín Castilla is affiliated with Ikerbasque in Spain and has a research focus primarily in biochemistry, genetics, and molecular biology. Their work predominantly explores molecular biology with a significant presence in neurology and nutrition and dietetics. The research also extends into infectious diseases and ecology, reflecting a multidisciplinary approach within life sciences.

The scientist's research topics cover a range of biomedical and molecular fields including prion diseases and protein misfolding, neurological diseases and metabolism, trace elements in health, RNA regulation and disease, as well as alcoholism and thiamine deficiency. Their studies also address infectious encephalopathies and encephalitis, alongside animal disease management and epidemiology.

Joaquín Castilla has published extensively on prion diseases and related neurodegenerative conditions. Some of the recent papers include:

  • Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein (2020), published in The FASEB Journal
  • Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear (2021), published in Scientific Reports
  • Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases (2021), published in International Journal of Molecular Sciences
  • Prion-Associated Neurodegeneration Causes Both Endoplasmic Reticulum Stress and Proteasome Impairment in a Murine Model of Spontaneous Disease (2021), published in International Journal of Molecular Sciences
  • Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation (2023), published in Acta Neuropathologica Communications

Their research outputs have appeared frequently in journals such as bioRxiv (Cold Spring Harbor Laboratory), PLoS Pathogens, International Journal of Molecular Sciences, Acta Neuropathologica Communications, and iScience.

Joaquín Castilla collaborates regularly with a core group of coauthors including Hasier Eraña, Jorge M. Charco, Carlos M. Díaz-Domínguez, Miguel A. Pérez-Castro, and Jesús R. Requena. These collaborations reflect ongoing partnerships within their research network especially in the field of prion and neurodegenerative disease studies.

Best Publications

  • In Vitro Generation of Infectious Scrapie Prions

    Joaquín Castilla;Paula Saá;Paula Saá;Claudio Hetz;Claudio Hetz;Claudio Soto

  • Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

    Claudio Hetz;Milene Russelakis‐Carneiro;Kinsey Maundrell;Joaquin Castilla

  • Production of cattle lacking prion protein.

    Jiirgen A. Richt;Poothappillai Kasinathan;Amir N. Hamir;Joaquin Castilla

  • Detection of prions in blood

    Joaquín Castilla;Paula Saá;Paula Saá;Claudio Soto

  • Ultra-efficient Replication of Infectious Prions by Automated Protein Misfolding Cyclic Amplification

    Paula Saá;Paula Saá;Joaquín Castilla;Claudio Soto

  • Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

    Claudio Soto;Lisbell Estrada;Joaquín Castilla

  • Presymptomatic Detection of Prions in Blood

    Paula Saá;Joaquín Castilla;Claudio Soto

  • The Disulfide Isomerase Grp58 Is a Protective Factor against Prion Neurotoxicity

    Claudio Hetz;Claudio Hetz;Milene Russelakis-Carneiro;Sébastien Wälchli;Sonia Carboni

  • Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure

    Rachel C. Angers;Hae-Eun Kang;Dana Napier;Shawn Browning

  • Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality

    Jatish Kumar;Hasier Eraña;Elena López-Martínez;Nathalie Claes

  • De novo induction of amyloid-β deposition in vivo.

    R Morales;C Duran-Aniotz;C Duran-Aniotz;J Castilla;J Castilla;L D Estrada;L D Estrada

  • Cell-free propagation of prion strains

    Joaquín Castilla;Rodrigo Morales;Rodrigo Morales;Paula Saá;Paula Saá;Marcelo Barria

  • Crossing the species barrier by PrPSc replication in vitro generates unique infectious Prions

    Joaquín Castilla;Dennisse Gonzalez-Romero;Paula Saá;Paula Saá;Rodrigo Morales;Rodrigo Morales

  • Molecular Cross-talk between Misfolded Proteins in Animal Models of Alzheimer’s and Prion Diseases

    Rodrigo Morales;Lisbell D. Estrada;Lisbell D. Estrada;Rodrigo Diaz-Espinoza;Rodrigo Diaz-Espinoza;Diego Morales-Scheihing

  • Pre-symptomatic detection of prions by cyclic amplification of protein misfolding

    Claudio Soto;Laurence Anderes;Silvia Suardi;Franco Cardone

  • Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis

    Claudio Hetz;Ann-Hwee Lee;Dennisse Gonzalez-Romero;Peter Thielen

  • Protein Misfolding Cyclic Amplification for Diagnosis and Prion Propagation Studies

    Joaquín Castilla;Paula Saá;Rodrigo Morales;Karim Abid

  • Isolation and characterization of a proteinase K-sensitive PrPSc fraction.

    Miguel A. Pastrana;Gustavo Sajnani;Bruce Onisko;Joaquin Castilla

  • Early detection of PrPres in BSE-infected bovine PrP transgenic mice.

    J Castilla;A Gutiérrez Adán;A Brun;B Pintado

  • A molecular switch controls interspecies prion disease transmission in mice

    Christina J. Sigurdson;K. Peter R. Nilsson;K. Peter R. Nilsson;Simone Hornemann;Simone Hornemann;Giuseppe Manco

Frequent Co-Authors

Claudio Soto
Claudio Soto The University of Texas Health Science Center at Houston
Christina J. Sigurdson
Christina J. Sigurdson University of California, San Diego
Claudio Hetz
Claudio Hetz University of Chile
Olivier Andreoletti
Olivier Andreoletti École Nationale Vétérinaire de Toulouse
Luis Enjuanes
Luis Enjuanes Spanish National Research Council
Adriano Aguzzi
Adriano Aguzzi University of Zurich
Isabel Sola
Isabel Sola Spanish National Research Council
Alfonso Gutiérrez-Adán
Alfonso Gutiérrez-Adán Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
Kurt Wüthrich
Kurt Wüthrich ETH Zurich
K. Peter R. Nilsson
K. Peter R. Nilsson Linköping University

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