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Claudio Hetz

Claudio Hetz

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Biology and Biochemistry
Chile
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
74233
World Ranking
1711
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Chile Leader Award
  • 2025 - Research.com Biology and Biochemistry in Chile Leader Award
  • 2023 - Research.com Biology and Biochemistry in Chile Leader Award
  • 2022 - Research.com Biology and Biochemistry in Chile Leader Award

Overview

Claudio Hetz is affiliated with the University of Chile in Chile and has a significant publication record in molecular and cellular biology, with a focus on biomedical research. Their work spans major fields such as Biochemistry, Genetics and Molecular Biology, and Medicine, with notable contributions in subfields including Cell Biology, Molecular Biology, Epidemiology, Cellular and Molecular Neuroscience, and Physiology.

Their recent publications cover a range of topics in cell stress responses and neurobiology. Notable papers include:

  • Mechanisms, regulation and functions of the unfolded protein response (2020) published in Nature Reviews Molecular Cell Biology
  • Adapting the proteostasis capacity to sustain brain healthspan (2021) published in Cell

Additional relevant papers related to cellular and molecular responses in disease, authored or coauthored by Hetz, include studies on unfolded protein response in cardiovascular diseases and apoptotic cell death mechanisms, showcasing interdisciplinary interests connected to cell stress and disease pathology.

Frequent co-authors collaborating with Claudio Hetz include:

  • Hery Urra
  • Lars Plate
  • Danilo B. Medinas
  • Philippe Pihán
  • Claudia Durán-Aniotz

In terms of publication venues, Claudio Hetz has contributed extensively to a variety of scientific journals and platforms, particularly:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The EMBO Journal
  • Neural Regeneration Research
  • Cell Death and Disease
  • Molecular Therapy

The main research topics addressed in their work include:

  • Endoplasmic Reticulum Stress and Disease
  • Autophagy in Disease and Therapy
  • Genetic Neurodegenerative Diseases
  • RNA Regulation and Disease
  • Mitochondrial Function and Pathology
  • Genetics, Aging, and Longevity in Model Organisms
  • Pancreatic Function and Diabetes

This blend of topics situates Claudio Hetz's research at the interface of molecular mechanisms and disease processes, with particular emphasis on cellular stress responses, neurodegeneration, and metabolism-related pathologies. Their output reflects a multidisciplinary approach integrating molecular biology, cell biology, and translational medicine.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • The unfolded protein response: controlling cell fate decisions under ER stress and beyond

    Claudio Hetz

  • Mechanisms, regulation and functions of the unfolded protein response.

    Claudio Hetz;Kezhong Zhang;Randal J. Kaufman

  • The Unfolded Protein Response and Cell Fate Control

    Claudio Hetz;Feroz R. Papa

  • In Vitro Generation of Infectious Scrapie Prions

    Joaquín Castilla;Paula Saá;Paula Saá;Claudio Hetz;Claudio Hetz;Claudio Soto

  • Targeting the unfolded protein response in disease

    Claudio Hetz;Eric Chevet;Heather P. Harding

  • Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia.

    Anna C. Schinzel;Osamu Takeuchi;Zhihong Huang;Jill K. Fisher

  • ER stress and the unfolded protein response in neurodegeneration

    Claudio Hetz;Smita Saxena

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α

    Claudio Hetz;Paula Bernasconi;Jill Fisher;Ann-Hwee Lee

  • Proteostasis control by the unfolded protein response.

    Claudio Hetz;Claudio Hetz;Eric Chevet;Scott A. Oakes

  • Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

    Cynthia Lebeaupin;Deborah Vallée;Younis Hazari;Claudio Hetz

  • Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

    Claudio Hetz;Bertrand Mollereau

  • The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

    Claudio Hetz;Fabio Martinon;Diego Rodriguez;Laurie H. Glimcher

  • XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

    Claudio Hetz;Peter Thielen;Soledad Matus;Melissa Nassif

  • Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

    Claudio Hetz;Claudio Hetz;Laurie H. Glimcher

  • Endoplasmic Reticulum Stress and the Hallmarks of Cancer

    Hery Urra;Estefanie Dufey;Tony Avril;Eric Chevet

Frequent Co-Authors

Felipe A. Court
Felipe A. Court Buck Institute for Research on Aging
Claudio Soto
Claudio Soto The University of Texas Health Science Center at Houston
Laurie H. Glimcher
Laurie H. Glimcher Harvard University
Sergio Lavandero
Sergio Lavandero University of Chile
Guido Kroemer
Guido Kroemer Université Paris Cité
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Afshin Samali
Afshin Samali University of Galway

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