World's Best Scientists 2026 revealed!
Paolo Bernardi

Paolo Bernardi

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Biology and Biochemistry
Italy
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
111
Citations
47103
World Ranking
934
National Ranking
10

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Italy Leader Award
  • 2025 - Research.com Biology and Biochemistry in Italy Leader Award
  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award
  • 2022 - Research.com Biology and Biochemistry in Italy Leader Award

Overview

Paolo Bernardi is affiliated with the University of Padua in Italy and focuses extensively on mitochondrial biology, particularly studying the mitochondrial permeability transition pore and its associated processes.

Their recent publications include:

  • Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions (2023, Cell Death and Differentiation)
  • The mitochondrial permeability transition: Recent progress and open questions (2021, FEBS Journal)
  • Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+-dependent death of cancer cells (2020, EMBO Reports)
  • Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase (2021, Nature Communications)
  • Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection (2020, Journal of Molecular and Cellular Cardiology)

The frequent co-authors of Paolo Bernardi include:

  • Michela Carraro
  • Giovanna Lippe
  • Andrea Rasola
  • Ludovica Tommasin
  • Christoph Gerle

The main publication venues where Bernardi's work regularly appears consist of:

  • Biochimica et Biophysica Acta (BBA) - Bioenergetics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular and Cellular Cardiology
  • Biophysical Journal
  • Cell Death and Differentiation

Bernardi's primary fields of study are Biochemistry, Genetics and Molecular Biology, with Medicine as a secondary focus. Within these disciplines, their subfields include Molecular Biology, Physiology, Clinical Biochemistry, Ecology, and Epidemiology.

The main scientific topics of their research encompass:

  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • Signaling Pathways in Disease
  • Adipose Tissue and Metabolism
  • Metabolism and Genetic Disorders
  • Cancer, Hypoxia, and Metabolism
  • RNA modifications and cancer

Best Publications

  • Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

    Paolo Bernardi

  • Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

    Marco Giorgio;Enrica Migliaccio;Francesca Orsini;Demis Paolucci

  • Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

    G. M. Cereghetti;A. Stangherlin;O. Martins de Brito;C. R. Chang

  • Mitochondria and cell death. Mechanistic aspects and methodological issues.

    Paolo Bernardi;Luca Scorrano;Raffaele Colonna;Valeria Petronilli

  • Dimers of mitochondrial ATP synthase form the permeability transition pore

    Valentina Giorgio;Sophia von Stockum;Manuela Antoniel;Astrid Fabbro

  • Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D

    Emy Basso;Emy Basso;Lisa Fante;Jonathan Fowlkes;Valeria Petronilli

  • Opening of the Mitochondrial Permeability Transition Pore Causes Depletion of Mitochondrial and Cytosolic NAD+and Is a Causative Event in the Death of Myocytes in Postischemic Reperfusion of the Heart

    Fabio Di Lisa;Roberta Menabò;Marcella Canton;Maria Barile

  • The mitochondrial permeability transition from in vitro artifact to disease target

    Paolo Bernardi;Alexandra Krauskopf;Emy Basso;Valeria Petronilli

  • Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence

    Valeria Petronilli;Giovanni Miotto;Marcella Canton;Marisa Brini

  • Mitochondria as all-round players of the calcium game.

    Rosario Rizzuto;Paolo Bernardi;Tullio Pozzan

  • Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane.

    Paolo Bernardi;Kimberly M. Broekemeier;Douglas R. Pfeiffer

  • Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis

    Andrea Rasola;Paolo Bernardi

  • High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.

    P. J. O’Brien;W. Irwin;D. Diaz;E. Howard-Cofield

  • Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

    P Bernardi

  • The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis

    Andrea Rasola;Paolo Bernardi

  • Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.

    Paola Costantini;Boris V. Chernyak;Valeria Petronilli;Paolo Bernardi

  • The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death: CORRELATION WITH THE DURATION OF PORE OPENINGS IN SITU

    Valeria Petronilli;Daniele Penzo;Luca Scorrano;Paolo Bernardi

  • The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

    Paolo Bernardi;Fabio Di Lisa

  • The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

    Paolo Bernardi;Andrea Rasola;Andrea Rasola;Andrea Rasola;Michael Forte;Giovanna Lippe;Giovanna Lippe;Giovanna Lippe

  • The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

    Paolo Bernardi;Valeria Petronilli

Frequent Co-Authors

Valeria Petronilli
Valeria Petronilli University of Padua
Michael Forte
Michael Forte Oregon Health & Science University
Andrea Rasola
Andrea Rasola University of Padua
Fabio Di Lisa
Fabio Di Lisa University of Padua
Paolo Bonaldo
Paolo Bonaldo University of Padua
Patrizia Sabatelli
Patrizia Sabatelli National Research Council (CNR)
Luciano Merlini
Luciano Merlini University of Bologna
Luca Scorrano
Luca Scorrano University of Padua
Ildikò Szabò
Ildikò Szabò University of Padua
Nadir M. Maraldi
Nadir M. Maraldi National Academies of Sciences, Engineering, and Medicine

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