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Biology and Biochemistry

D-Index
128
Citations
84787
World Ranking
435
National Ranking
278

Overview

John J. Lemasters is affiliated with the Medical University of South Carolina in the United States. Their research spans multiple areas within medicine and biochemistry, notably focusing on liver disease, mitochondrial function, and autophagy.

The primary fields of study covered by Lemasters include Medicine and Biochemistry, Genetics and Molecular Biology. Their subfields encompass Molecular Biology, Epidemiology, Hepatology, Surgery, and Pharmacology.

The main topics addressed in their work are:

  • Liver Disease Diagnosis and Treatment
  • Mitochondrial Function and Pathology
  • Autophagy in Disease and Therapy
  • Liver Disease and Transplantation
  • Organ Transplantation Techniques and Outcomes
  • Drug-Induced Hepatotoxicity and Protection
  • Liver physiology and pathology

Lemasters has published extensively, with recent papers including:

  • Iron loss triggers mitophagy through induction of mitochondrial ferritin, 2020, EMBO Reports
  • Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice, 2022, Autophagy
  • Selective degradation of mitochondria by mitophagy, 2020, UNC Libraries
  • The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice, 2022, Toxicology and Applied Pharmacology
  • Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline, 2020, Toxicology and Applied Pharmacology

Their research has appeared frequently in several publication venues, including:

  • UNC Libraries
  • Toxicology and Applied Pharmacology
  • Gastroenterology
  • Cancer Research
  • EMBO Reports

Collaboration is a notable aspect of their work. Frequent coauthors include:

  • Zhi Zhong
  • Jiangting Hu
  • Devadoss J. Samuvel
  • Ekhson Holmuhamedov
  • Yasodha Krishnasamy

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

    Guifang Jia;Ye Fu;Xu Zhao;Xu Zhao;Qing Dai

  • Selective degradation of mitochondria by mitophagy.

    Insil Kim;Sara Rodriguez-Enriquez;John J. Lemasters

  • The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.

    John J. Lemasters;Anna Liisa Nieminen;Ting Qian;Lawrence C. Trost;Lawrence C. Trost

  • Mechanisms of Hepatotoxicity

    Hartmut Jaeschke;Gregory J. Gores;Arthur I. Cederbaum;Jack A. Hinson

  • Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

    John J Lemasters

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties

    Ronald K. Emaus;Ron Grunwald;John J. Lemasters

  • Mitochondrial permeability transition: a common pathway to necrosis and apoptosis.

    Jae Sung Kim;Lihua He;John J. Lemasters

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Apoptosis and necrosis in the liver: a tale of two deaths?

    Harmeet Malhi;Gregory J. Gores;John J. Lemasters

  • Mitochondrial calcium and the permeability transition in cell death.

    John J. Lemasters;Tom P. Theruvath;Zhi Zhong;Anna-Liisa Nieminen

  • The mitochondrial permeability transition initiates autophagy in rat hepatocytes

    Steven P. Elmore;Ting Qian;Sherry F. Grissom;John J. Lemasters

  • NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis

    Ramón Bataller;Robert F. Schwabe;Youkyung H. Choi;Liu Yang

  • Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury.

    Hartmut Jaeschke;John J Lemasters

  • Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes

    John J. Lemasters;James Diguiseppi;Anna Liisa Nieminen;Brian Herman

  • Voltage-dependent anion channel (VDAC) as mitochondrial governator—Thinking outside the box

    John J. Lemasters;Ekhson Holmuhamedov

  • V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis

    John J. Lemasters

Frequent Co-Authors

Ronald G. Thurman
Ronald G. Thurman University of North Carolina at Chapel Hill
Brian Herman
Brian Herman The University of Texas Health Science Center at San Antonio
David A. Brenner
David A. Brenner University of California, San Diego
Hartmut Jaeschke
Hartmut Jaeschke University of Kansas
Rick G. Schnellmann
Rick G. Schnellmann Medical University of South Carolina
Ronald P. Mason
Ronald P. Mason National Institutes of Health
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Gerry Melino
Gerry Melino University of Rome Tor Vergata
Nektarios Tavernarakis
Nektarios Tavernarakis Foundation for Research and Technology Hellas
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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