World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
133
Citations
67969
World Ranking
2219
National Ranking
1252

Overview

Hartmut Jaeschke is affiliated with the University of Kansas in the United States and has contributed extensively to the fields of medicine, pharmacology, toxicology, and pharmaceutics. Their research focuses largely on drug-induced hepatotoxicity, liver disease, and mechanisms of liver injury and protection.

The scientist's work covers several key research topics including:

  • Drug-Induced Hepatotoxicity and Protection
  • Liver Disease and Transplantation
  • Liver Disease Diagnosis and Treatment
  • Drug Transport and Resistance Mechanisms
  • Liver physiology and pathology
  • Pharmacogenetics and Drug Metabolism
  • Poisoning and overdose treatments

Hartmut Jaeschke has published in prominent scientific venues with a high frequency in:

  • Toxicological Sciences
  • Archives of Toxicology
  • Journal of Biochemical and Molecular Toxicology
  • Livers
  • Toxicology Letters

Frequent collaborators include Anup Ramachandran, Jephte Y. Akakpo, David S. Umbaugh, Nga Nguyen, and Steven C. Curry.

The scientist's recent papers illustrate their focus on liver toxicity and therapeutic approaches. Selected works include:

  • "The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress" (2020) published in Current Neuropharmacology
  • "Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure" (2020) published in Toxicological Sciences
  • "Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury" (2024) published in Annual Review of Pathology Mechanisms of Disease
  • "Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity" (2020) published in Food and Chemical Toxicology
  • "Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls" (2021) published in Acta Pharmaceutica Sinica B

Their dominant subfields of study include pharmacology, hepatology, epidemiology, oncology, and molecular biology, reflecting a multidisciplinary approach within biomedical sciences.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Mechanisms of Hepatotoxicity

    Hartmut Jaeschke;Gregory J. Gores;Arthur I. Cederbaum;Jack A. Hinson

  • Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning.

    Hartmut Jaeschke

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

    Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

  • Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver

    Hartmut Jaeschke;Anwar Farhood

  • Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

    Hartmut Jaeschke;Mitchell R. McGill;Anup Ramachandran

  • Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo.

    H Jaeschke;A Farhood;C W Smith

  • The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.

    Mitchell R. McGill;Matthew R. Sharpe;C. David Williams;Mohammad Taha

  • Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury.

    Hartmut Jaeschke;John J Lemasters

  • METABOLISM AND DISPOSITION OF ACETAMINOPHEN: RECENT ADVANCES IN RELATION TO HEPATOTOXICITY AND DIAGNOSIS

    Mitchell R. McGill;Hartmut Jaeschke

  • Intracellular Signaling Mechanisms of Acetaminophen-Induced Liver Cell Death

    Hartmut Jaeschke;Mary Lynn Bajt

  • Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts.

    Hartmut Jaeschke

  • Mechanisms of neutrophil-induced parenchymal cell injury

    H Jaeschke;C W Smith

  • Bile Acids Induce Inflammatory Genes in Hepatocytes: A Novel Mechanism of Inflammation during Obstructive Cholestasis

    Katryn Allen;Hartmut Jaeschke;Bryan L. Copple

  • Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions

    Hartmut Jaeschke

  • Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes.

    Kazuyoshi Kon;Jae-Sung Kim;Hartmut Jaeschke;John J. Lemasters

  • The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity.

    Hartmut Jaeschke;Tamara R Knight;Tamara R Knight;Mary Lynn Bajt

  • Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

    Hartmut Jaeschke;C. David Williams;Anup Ramachandran;Mary L. Bajt

  • Mode of Cell Death after Acetaminophen Overdose in Mice: Apoptosis or Oncotic Necrosis?

    Jaspreet S. Gujral;Tamara R. Knight;Anwar Farhood;Mary Lynn Bajt

  • Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: apoptosis or necrosis?

    Jaspreet S. Gujral;Thomas J. Bucci;Thomas J. Bucci;Anwar Farhood;Hartmut Jaeschke

Frequent Co-Authors

Wen-Xing Ding
Wen-Xing Ding University of Kansas
John J. Lemasters
John J. Lemasters Medical University of South Carolina
Mathieu Vinken
Mathieu Vinken Vrije Universiteit Brussel
Christian Trautwein
Christian Trautwein RWTH Aachen University
James L. Boyer
James L. Boyer Yale University
Michael Fisher
Michael Fisher University of Manchester
Ronald P.J. Oude Elferink
Ronald P.J. Oude Elferink University of Amsterdam
Jorge Rakela
Jorge Rakela Mayo Clinic
Tania Roskams
Tania Roskams KU Leuven
Michael Trauner
Michael Trauner Medical University of Vienna

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

The journey to a medical career in the USA can be diverse, offering alternative paths beyond a traditional MD. Many students explore programs designed for faster entry into healthcare professions or look for flexible learning options that fit their schedules.

For those drawn to nursing but lacking a clinical background, online msn programs for non nurses and online bsn programs for non nurses provide accelerated, direct-entry pathways. These programs allow students with non-nursing degrees to quickly transition into high-demand nursing roles.

If you’re interested in healthcare administration or prefer a non-clinical route, consider medical billing and coding online schools that accept financial aid. These programs offer both flexibility and accessibility, often leading to stable and growing job opportunities.

Some aspiring nurses may be concerned about rigorous entrance exams. Fortunately, there are nursing schools that don't require teas or hesi, removing a significant barrier and opening doors for more students.

Exploring these online degree options can help you find a healthcare career pathway that fits your goals, schedule, and background.

Best Scientists Citing Hartmut Jaeschke

Trending Scientists