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Medicine

D-Index
105
Citations
43101
World Ranking
6742
National Ranking
3558

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Paul B. Watkins is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily spans the fields of Medicine and Pharmacology, Toxicology and Pharmaceutics, with 94 and 51 publications respectively. Subfields of particular focus include Pharmacology, Epidemiology, Molecular Biology, Hepatology, and Pediatrics, Perinatology and Child Health.

The main research topics covered by Watkins include:

  • Drug-Induced Hepatotoxicity and Protection
  • Pharmacogenetics and Drug Metabolism
  • Liver Disease Diagnosis and Treatment
  • Drug Transport and Resistance Mechanisms
  • Pharmacological Effects and Toxicity Studies
  • Poisoning and overdose treatments
  • Hepatitis C virus research

Watkins has contributed to numerous scientific publications, with significant numbers appearing in venues such as UNC Libraries (40 publications), Clinical Pharmacology & Therapeutics (7 publications), Toxicological Sciences (3 publications), Clinical and Translational Science (3 publications), and Frontiers in Pharmacology (2 publications).

Recent notable papers include:

  • Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables, 2020, Frontiers in Pharmacology
  • Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial, 2020, Clinical Pharmacology & Therapeutics
  • Polygenic architecture informs potential vulnerability to drug-induced liver injury, 2020, Nature Medicine
  • Human Leukocyte Antigen B*14:01 and B*35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury, 2020, Hepatology
  • Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens, 2020, Clinical Pharmacology & Therapeutics

Frequent co-authors collaborating with Watkins include:

  • Robert J. Fontana
  • Naga Chalasani
  • Guruprasad P. Aithal
  • Andrew Stolz
  • Huiman X. Barnhart

Watkins has been recognized as a Member of the Association of American Physicians, an acknowledgment reflecting professional standing within the medical research community.

Best Publications

  • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.

    Peter Kuehl;Jiong Zhang;Yvonne Lin;Jatinder Lamba

  • Case definition and phenotype standardization in drug-induced liver injury

    GP Aithal;PB Watkins;RJ Andrade;D Larrey

  • Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation A New Drug–Drug Interaction

    Wei C. Lau;Lucy A. Waskell;Paul B. Watkins;Charlene J. Neer

  • Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States

    Naga Chalasani;Robert J. Fontana;Herbert L. Bonkovsky;Herbert L. Bonkovsky;Herbert L. Bonkovsky;Paul B. Watkins

  • Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease.

    Paul B. Watkins;Hyman J. Zimmerman;Margaret J. Knapp;Stephen I. Gracon

  • Features and outcomes of 899 patients with drug-induced liver injury: The DILIN prospective study

    Naga Chalasani;Herbert L. Bonkovsky;Robert Fontana;William Lee

  • Role of intestinal P‐glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

    Kenneth S. Lown;Kenneth S. Lown;Robert R. Mayo;Robert R. Mayo;Alan B. Leichtman;Alan B. Leichtman;Hsiu Ling Hsiao;Hsiu Ling Hsiao

  • Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

    Kenneth S. Lown;David G. Bailey;Robert J. Fontana;Srinivas K. Janardan

  • Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily: A Randomized Controlled Trial

    Paul B. Watkins;Neil Kaplowitz;John T. Slattery;Connie R. Colonese

  • Contribution of Hepatic Cytochrome P450 3A4 Metabolic Activity to the Phenomenon of Clopidogrel Resistance

    Wei C. Lau;Paul A. Gurbel;Paul B. Watkins;Charlene J. Neer

  • Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

    Joseph C. Kolars;Phyllissa Schmiedlin-Ren;John D. Schuetz;Che Fang

  • Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

    P B Watkins;S A Wrighton;E G Schuetz;D T Molowa

  • Hepatic Dysfunction Associated with Troglitazone

    Paul B. Watkins;Randall W. Whitcomb

  • Drug-Induced Liver Injury Network (DILIN) Prospective Study: Rationale, Design and Conduct

    Robert J. Fontana;Paul B. Watkins;Herbert L. Bonkovsky;Naga Chalasani

  • Noninvasive tests of CYP3A enzymes.

    Paul B. Watkins

  • Liver transplantation for acute liver failure from drug induced liver injury in the United States

    Mark W. Russo;Joseph A. Galanko;Roshan Shrestha;Michael W. Fried

  • Drug-induced liver injury

    Raul J Andrade;Naga Chalasani;Einar S Björnsson;Ayako Suzuki;Ayako Suzuki

  • CYP3A gene expression in human gut epithelium.

    Joseph C. Kolars;Kenneth S. Lown;Phyllissa Schmiedlin-Ren;Mita Ghosh

  • First-pass metabolism of cyclosporin by the gut.

    Joseph C. Kolars;P. B. Watkins;Robert M. Merion;W. M. Awni

  • Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

    N. Chalasani;H. L. Bonkovsky;R. Fontana;W. Lee

Frequent Co-Authors

Robert J. Fontana
Robert J. Fontana University of Michigan–Ann Arbor
Naga Chalasani
Naga Chalasani Indiana University
Steven A. Wrighton
Steven A. Wrighton Eli Lilly (United States)
Kenneth E. Thummel
Kenneth E. Thummel University of Washington
Guruprasad P. Aithal
Guruprasad P. Aithal University of Nottingham
Ann K. Daly
Ann K. Daly Newcastle University
Erin G. Schuetz
Erin G. Schuetz St. Jude Children's Research Hospital
Neil Kaplowitz
Neil Kaplowitz University of Southern California
Kim L. R. Brouwer
Kim L. R. Brouwer University of North Carolina at Chapel Hill
Einar Bjornsson
Einar Bjornsson University of Iceland

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