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Michel Eichelbaum

Michel Eichelbaum

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Medicine
Germany
2023

D-Index & Metrics

Medicine

D-Index
122
Citations
50181
World Ranking
3498
National Ranking
186

Research.com Recognitions

  • 2023 - Research.com Medicine in Germany Leader Award

Overview

Michel Eichelbaum is affiliated with the University of Tübingen in Germany and focuses research efforts primarily in the fields of biochemistry, genetics, molecular biology, pharmacology, toxicology, pharmaceutics, and medicine. Their work spans multiple interconnected disciplines, reflecting a broad and integrative approach to biomedical sciences.

The scientist's research encompasses several subfields, including pharmacology, genetics, oncology, organic chemistry, and cell biology. The main topics of their scholarly activity involve pharmacogenetics and drug metabolism, genetic associations and epidemiology, estrogen and related hormone effects, drug transport and resistance mechanisms, antibiotics pharmacokinetics and efficacy, axial and atropisomeric chirality synthesis, as well as microtubule and mitosis dynamics.

Michel Eichelbaum's recent publication record features the following papers:

  • Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations, 2023, Clinical Pharmacology & Therapeutics
  • Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins, 2021, British Journal of Pharmacology
  • Cytotoxicity of Atropisomeric [1,1'-Binaphthalene]-2,2'-Diamines (BINAM) and Analogs in Human Cancer Cells: Enantioselectivity, Structure-Activity Relationships, and Mechanism, 2025, ChemMedChem

Frequent co-authors associated with Michel Eichelbaum include:

  • Stefan Winter
  • Kathrin Klein
  • Elke Schaeffeler
  • Matthias Schwab
  • Chiea Chuen Khor

The scientist has contributed to research published predominantly in the following venues:

  • Clinical Pharmacology & Therapeutics
  • British Journal of Pharmacology
  • ChemMedChem

Best Publications

  • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

    S. Hoffmeyer;O. Burk;O. von Richter;H. P. Arnold

  • The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

    Bernd Greiner;Michel Eichelbaum;Peter Fritz;Hans-Peter Kreichgauer

  • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin.

    Anke Geick;Michel Eichelbaum;Oliver Burk

  • Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

    Ulrich M. Zanger;Sebastian Raimundo;Michel Eichelbaum

  • Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

    Ingolf Cascorbi;Thomas Gerloff;Andreas Johne;Christian Meisel

  • Defective N-oxidation of sparteine in man: a new pharmacogenetic defect.

    M. Eichelbaum;N. Spannbrucker;Barbara Steincke;H. J. Dengler

  • Pharmacogenomics and Individualized Drug Therapy

    Michel Eichelbaum;Magnus Ingelman-Sundberg;William E. Evans

  • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

    Thomas Lang;Kathrin Klein;Joachim Fischer;Andreas K. Nüssler

  • Association Between CYP2D6 Polymorphisms and Outcomes Among Women With Early Stage Breast Cancer Treated With Tamoxifen

    Werner Schroth;Matthew P. Goetz;Ute Hamann;Peter A. Fasching;Peter A. Fasching

  • Sex is a major determinant of CYP3A4 expression in human liver

    Renzo Wolbold;Kathrin Klein;Oliver Burk;Andreas K. Nüssler

  • Nomenclature for human CYP2D6 alleles.

    A K Daly;J Brockmoller;F Broly;M Eichelbaum

  • Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes.

    Werner Schroth;Lydia Antoniadou;Peter Fritz;Matthias Schwab

  • The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

    M. Eichelbaum;A.S. Gross

  • Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

    Elke Schaeffeler;Christine Fischer;Dierk Brockmeier;Dorothee Wernet

  • Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury is Influenced by Multiple HLA Class I and II Alleles

    M. Isabel Lucena;Mariam Molokhia;Yufeng Shen;Thomas J. Urban

  • High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).

    Mikko Niemi;Elke Schaeffeler;Thomas Lang;Martin F Fromm

  • The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells.

    Monika Hitzl;Siegfried Drescher;Heiko Van Der Kuip;Elke Schäffeler

  • Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group

    Matthias Schwab;Ulrich M. Zanger;Claudia Marx;Elke Schaeffeler

  • The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions.

    KT Kivisto;HK Kroemer;M. Eichelbaum

  • Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics.

    Mikko Niemi;Mikko Niemi;Mikko Niemi;Janne T. Backman;Janne T. Backman;Janne T. Backman;Lauri I. Kajosaari;Lauri I. Kajosaari;Lauri I. Kajosaari;Julian B. Leathart;Julian B. Leathart;Julian B. Leathart

Frequent Co-Authors

Matthias Schwab
Matthias Schwab University of Tübingen
Martin F. Fromm
Martin F. Fromm University of Erlangen-Nuremberg
Ulrich M. Zanger
Ulrich M. Zanger Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Ute Hofmann
Ute Hofmann University of Tübingen
Heyo K. Kroemer
Heyo K. Kroemer University of Göttingen
Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Kathrin Klein
Kathrin Klein Robert Bosch (Germany)
Andrew A. Somogyi
Andrew A. Somogyi University of Adelaide
Mikko Niemi
Mikko Niemi University of Helsinki
Ulrich Brinkmann
Ulrich Brinkmann Roche (Switzerland)

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