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Genetics

D-Index
50
Citations
11646
World Ranking
3912
National Ranking
264

Overview

Kathrin Klein is affiliated with Robert Bosch in Germany and focuses primarily on medical research, with a substantial contribution to the fields of oncology, pharmacology, epidemiology, surgery, and genetics.

Their research includes extensive work in pharmacogenetics and drug metabolism, drug transport and resistance mechanisms, and liver disease diagnosis and treatment. Further topics covered by their research include metabolism and genetic disorders, 3D printing in biomedical research, liver physiology and pathology, and renal transplantation outcomes and treatments.

Klein's publications have appeared frequently in several scientific journals. Notable publication venues include:

  • Clinical Pharmacology & Therapeutics
  • Advanced Science
  • International Journal of Molecular Sciences
  • Scientific Reports
  • Frontiers in Pharmacology

Klein has coauthored numerous papers with recurring collaborators such as Matthias Schwab (12 papers), Volker M. Lauschke (7 papers), Roman Tremmel (6 papers), Elke Schaeffeler (5 papers), and Ute Hofmann (5 papers).

Significant recent publications by Klein include:

  • PharmVar GeneFocus: CYP2B6, 2021, Clinical Pharmacology & Therapeutics
  • Bioengineered Pancreas-Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia, 2022, Advanced Science
  • Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations, 2023, Clinical Pharmacology & Therapeutics
  • The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function, 2024, Biotechnology Journal
  • Saturated Fat-Mediated Upregulation of IL-32 and CCL20 in Hepatocytes Contributes to Higher Expression of These Fibrosis-Driving Molecules in MASLD, 2023, International Journal of Molecular Sciences

Best Publications

  • The genetic determinants of the CYP3A5 polymorphism

    Elisabeth Hustert;Michael Haberl;Oliver Burk;Renzo Wolbold

  • Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

    Ulrich M. Zanger;Ulrich M. Zanger;Miia Turpeinen;Miia Turpeinen;Miia Turpeinen;Kathrin Klein;Kathrin Klein;Matthias Schwab;Matthias Schwab

  • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

    Thomas Lang;Kathrin Klein;Joachim Fischer;Andreas K. Nüssler

  • Sex is a major determinant of CYP3A4 expression in human liver

    Renzo Wolbold;Kathrin Klein;Oliver Burk;Andreas K. Nüssler

  • Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group

    Matthias Schwab;Ulrich M. Zanger;Claudia Marx;Elke Schaeffeler

  • Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

    Anne T. Nies;Hermann Koepsell;Stefan Winter;Stefan Winter;Oliver Burk

  • Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz.

    Kathrin Klein;Thomas Lang;Tanja Saussele;Eduardo Barbosa-Sicard

  • Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance

    Ulrich M. Zanger;Kathrin Klein

  • Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.

    Ulrich M Zanger;Kathrin Klein;Kathrin Klein;Tanja Saussele;Tanja Saussele;Julia Blievernicht;Julia Blievernicht

  • Interindividual variability of canalicular ATP-binding-cassette (ABC)–transporter expression in human liver

    Yvonne Meier;Christiane Pauli-Magnus;Ulrich M. Zanger;Kathrin Klein

  • Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro.

    Zeruesenay Desta;Tanja Saussele;Bryan Ward;Julia Blievernicht

  • Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver.

    Marco H. Hofmann;Julia K. Blievernicht;Kathrin Klein;Tanja Saussele

  • Molecular Mechanisms of Polymorphic CYP3A7 Expression in Adult Human Liver and Intestine

    Oliver Burk;Heike Tegude;Ina Koch;Elisabeth Hustert

  • Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.

    Kathrin Klein;Ulrich M. Zanger

  • A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects.

    Sebastian Raimundo;Claudia Toscano;Kathrin Klein;Joachim Fischer

  • PharmVar GeneFocus: CYP2D6.

    Zeruesenay Desta;Ahmed El-Boraie;Li Gong;Andrew A Somogyi

  • Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver.

    Nina Kassner;Klaus Huse;Hans-Jörg Martin;Ute Gödtel-Armbrust

  • Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease

    Yijing Zhang;Kathrin Klein;Aarathi Sugathan;Najlla Nassery

  • PPARA: a novel genetic determinant of CYP3A4 in vitro and in vivo.

    Kathrin Klein;Maria Thomas;Stefan Winter;Andreas K. Nussler

  • The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.

    Janet K. Coller;Janet K. Coller;Niels Krebsfaenger;Kathrin Klein;Karin Endrizzi

Frequent Co-Authors

Ulrich M. Zanger
Ulrich M. Zanger Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Matthias Schwab
Matthias Schwab University of Tübingen
Michel Eichelbaum
Michel Eichelbaum University of Tübingen
Ute Hofmann
Ute Hofmann University of Tübingen
Thomas Lang
Thomas Lang University of California, San Francisco
Andreas K. Nussler
Andreas K. Nussler University of Tübingen
Peter Neuhaus
Peter Neuhaus Charité - University Medicine Berlin
Jürgen Brockmöller
Jürgen Brockmöller University of Göttingen
Martin F. Fromm
Martin F. Fromm University of Erlangen-Nuremberg
Peter Nürnberg
Peter Nürnberg University of Cologne

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