World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
111
Citations
50268
World Ranking
930
National Ranking
580

Medicine

D-Index
110
Citations
50059
World Ranking
5514
National Ranking
2973

Overview

David J. Waxman is affiliated with Boston University in the United States. Their research spans a broad range of topics primarily within biochemistry, genetics, and molecular biology, with significant contributions to medicine.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their subfields of study show focused research efforts in:

  • Molecular Biology
  • Cancer Research
  • Epidemiology
  • Endocrinology, Diabetes and Metabolism
  • Genetics

Major topics covered in their work involve:

  • Cancer-related molecular mechanisms research
  • RNA Research and Splicing
  • Liver Disease Diagnosis and Treatment
  • RNA modifications and cancer
  • Genomics and Chromatin Dynamics
  • Growth Hormone and Insulin-like Growth Factors
  • Adipose Tissue and Metabolism

David J. Waxman has multiple recent scientific publications. Selected papers include:

  • Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting (2020, Nature Communications)
  • MAnorm2 for quantitatively comparing groups of ChIP-seq samples (2020, Genome Research)
  • Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2 (2020, PLoS Genetics)
  • Interplay Between GH-regulated, Sex-biased Liver Transcriptome and Hepatic Zonation Revealed by Single-Nucleus RNA Sequencing (2022, Endocrinology)
  • Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver (2020, Epigenetics & Chromatin)

The scientist has published frequently in several venues, including:

  • Biorxiv (Cold Spring Harbor Laboratory)
  • Toxicological Sciences
  • Endocrinology
  • PLoS Genetics
  • BMC Genomics

Collaborative work has been conducted extensively with coauthors such as:

  • Kritika Karri
  • Cameron Vergato
  • Rhonda D. Kineman
  • Christine N. Goldfarb
  • Darren Roblyer

Best Publications

  • P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature

    David R. Nelson;Luc Koymans;Tetsuya Kamataki;John J. Stegeman

  • The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.

    D R Nelson;T Kamataki;D J Waxman;F P Guengerich

  • The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.

    D W Nebert;D R Nelson;M J Coon;R W Estabrook

  • Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

    Garry B. Udy;Raewyn P. Towers;Russell G. Snell;Richard J. Wilkins

  • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

    F P Guengerich;M V Martin;P H Beaune;P Kremers

  • P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

    David J. Waxman

  • Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics.

    David J. Waxman;Jack L. Strominger

  • An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

    Wen Xie;Anna Radominska-Pandya;Yanhong Shi;Cynthia M. Simon

  • Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

    David J. Waxman;Minita G. Holloway

  • Child health, developmental plasticity, and epigenetic programming.

    Z. Hochberg;Robert Feil;M. Constancia;M. Fraga

  • Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

    D J Waxman;G A Dannan;F P Guengerich

  • Phenobarbital induction of cytochrome P-450 gene expression.

    D J Waxman;L Azaroff

  • Differential Activation of Cyclophosphamide and Ifosphamide by Cytochromes P-450 2B and 3A in Human Liver Microsomes

    Thomas K. H. Chang;Georg F. Weber;Charles L. Crespi;David J. Waxman

  • Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.

    T Aoyama;S Yamano;D J Waxman;D P Lapenson

  • Growth Hormone Regulation of Sex-Dependent Liver Gene Expression

    David J. Waxman;Caitlin O’Connor

  • Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression.

    David J. Waxman

  • Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

    D J Waxman;C Attisano;F P Guengerich;D P Lapenson

  • Activation of PPARα and PPARγ by Environmental Phthalate Monoesters

    Christopher H. Hurst;David J. Waxman

  • MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets

    Zhen Shao;Zhen Shao;Yijing Zhang;Guo-Cheng Yuan;Stuart H Orkin;Stuart H Orkin;Stuart H Orkin

  • trans-activation of PPARα and PPARγ by structurally diverse environmental chemicals

    Erin K. Maloney;David J. Waxman

Frequent Co-Authors

Jack L. Strominger
Jack L. Strominger Harvard University
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Gerald A. LeBlanc
Gerald A. LeBlanc North Carolina State University
Charles L. Crespi
Charles L. Crespi Corning (United States)
Xandra O. Breakefield
Xandra O. Breakefield Harvard University
Christopher T. Walsh
Christopher T. Walsh Stanford University
Joyce A. Goldstein
Joyce A. Goldstein National Institutes of Health
Gert Kreibich
Gert Kreibich New York University
F. Peter Guengerich
F. Peter Guengerich Vanderbilt University
Daniel W. Nebert
Daniel W. Nebert University of Cincinnati

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