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Chemistry

D-Index
62
Citations
12399
World Ranking
8919
National Ranking
2535

Biology and Biochemistry

D-Index
62
Citations
12348
World Ranking
10910
National Ranking
4726

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Paul F. Hollenberg is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of Pharmacology, Toxicology and Pharmaceutics, and Medicine, with a focus on Pharmacology, Computational Theory and Mathematics, Molecular Biology, and Pathology and Forensic Medicine as specific subfields of study.

The research topics covered by Hollenberg include Pharmacogenetics and Drug Metabolism, Computational Drug Discovery Methods, Steroid Chemistry and Biochemistry, Cannabis and Cannabinoid Research, and Alcohol Consumption and Health Effects.

Notable recent publications include the following works:

  • Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase (2021, Journal of Biological Chemistry)
  • Assay of Endocannabinoid Oxidation by Cytochrome P450 (2022, Methods in molecular biology)

Frequent co-authors in their collaborative research efforts have included:

  • Cheng Shen
  • Zhiyuan Bo
  • Yoichi Osawa
  • Haoming Zhang
  • Natasha T. Snider

Hollenberg has published in journals such as:

  • Journal of Biological Chemistry
  • Methods in molecular biology

In 2012, Paul F. Hollenberg was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents : Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

    Phyllissa Schmiedlin-Ren;David J. Edwards;Michael E. Fitzsimmons;Kan He

  • Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

    Kan He;Krishna R. Iyer;Roger N. Hayes;Michael W. Sinz

  • Inhibition of Cytochrome P450 Enzymes

    Maria Almira Correia;Paul. F. Hollenberg

  • Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes.

    Paul F. Hollenberg

  • A nonsynchronous concerted mechanism for cytochrome P-450 catalyzed hydroxylation

    Martin Newcomb;Marie Hélène Le Tadic-Biadatti;Daryl L. Chestney;Elizabeth S. Roberts

  • SILYBIN INACTIVATES CYTOCHROMES P450 3A4 AND 2C9 AND INHIBITS MAJOR HEPATIC GLUCURONOSYLTRANSFERASES

    Chitra Sridar;Theunis C. Goosen;Ute M. Kent;J. Andrew Williams

  • Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

    Martin Newcomb;Runnan Shen;Seung Yong Choi;Patrick H. Toy

  • Role of the Alanine at Position 363 of Cytochrome P450 2B2 in Influencing the NADPH- and Hydroperoxide-Supported Activities☆☆☆

    Imad H. Hanna;John F. Teiber;Kristin L. Kokones;Paul F. Hollenberg;Paul F. Hollenberg

  • Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.

    Krishna C. Chimalakonda;Kathryn A. Seely;Stacie M. Bratton;Lisa K. Brents

  • Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations.

    Martin Newcomb;Paul F Hollenberg;Minor J Coon

  • The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9.

    Ute M. Kent;Michael Aviram;Mira Rosenblat;Paul F. Hollenberg

  • Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

    Paul F. Hollenberg;Ute M. Kent;Namandjé N. Bumpus

  • The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes

    Dean Ahn;David Putt;Laura Kresty;Gary D. Stoner

  • Mechanism-based inactivators as probes of cytochrome P450 structure and function.

    U M Kent;M I Juschyshyn;P F Hollenberg

  • Subunit structure of rabbit muscle pyruvate kinase.

    Gene L. Cottam;Paul F. Hollenberg;Minor J. Coon

  • Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17α-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein

    Hsia Lien Lin;Ute M. Kent;Paul F. Hollenberg

  • The P-450 Nature of the Carbon Monoxide Complex of Ferrous Chloroperoxidase

    Paul F. Hollenberg;Lowell P. Hager

  • Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications

    Natasha T. Snider;Vyvyca J. Walker;Paul F. Hollenberg

  • Expression of human cytochrome P450 2B6 in Escherichia coli: Characterization of catalytic activity and expression levels in human liver

    Imad H. Hanna;James R. Reed;F.Peter Guengerich;Paul F. Hollenberg

  • Mechanisms of cytochrome P450 and peroxidase-catalyzed xenobiotic metabolism.

    Paul F. Hollenberg

  • Hydroxylation by the Hydroperoxy-Iron Species in Cytochrome P450 Enzymes

    R. Esala P. Chandrasena;Kostas P. Vatsis;Minor J. Coon;Paul F. Hollenberg

  • The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450- and peroxidase-catalyzed N-demethylation reactions.

    Unknown

Frequent Co-Authors

Martin Newcomb
Martin Newcomb University of Illinois at Chicago
Minor J. Coon
Minor J. Coon University of Michigan–Ann Arbor
Lucy Waskell
Lucy Waskell University of Michigan–Ann Arbor
Dafydd G. Thomas
Dafydd G. Thomas University of Michigan–Ann Arbor
Lowell P. Hager
Lowell P. Hager University of Illinois at Urbana-Champaign
David P. Ballou
David P. Ballou University of Michigan–Ann Arbor
Thomas J. Giordano
Thomas J. Giordano University of Michigan–Ann Arbor
Patrick M. Woster
Patrick M. Woster Medical University of South Carolina
James R. Halpert
James R. Halpert University of Connecticut

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