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Biology and Biochemistry

D-Index
55
Citations
9214
World Ranking
15220
National Ranking
6363

Overview

Xinxin Ding is affiliated with the University of Arizona in the United States and has a significant body of research primarily within the field of Biochemistry, Genetics and Molecular Biology.

The scope of Ding's work spans several subfields including Molecular Biology, Pharmacology, Biomedical Engineering, Spectroscopy, and Plant Science. Research topics are concentrated around Pharmacogenetics and Drug Metabolism, Catalysis for Biomass Conversion, Analytical Chemistry and Chromatography, Catalysts for Methane Reforming, Eicosanoids and Hypertension Pharmacology, Autophagy in Disease and Therapy, and Genomics, Phytochemicals, and Oxidative Stress.

Ding has published extensively in various scientific journals. Frequent publication venues include:

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • SSRN Electronic Journal
  • The FASEB Journal
  • Acta Pharmaceutica Sinica B

Their recent notable papers encompass a range of topics from drug metabolism to cellular autophagy mechanisms, including:

  • Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development, 2022, Acta Pharmaceutica Sinica B
  • Reticulon proteins modulate autophagy of the endoplasmic reticulum in maize endosperm, 2020, eLife
  • Autophagy Plays Prominent Roles in Amino Acid, Nucleotide, and Carbohydrate Metabolism during Fixed-Carbon Starvation in Maize, 2020, The Plant Cell
  • Molecular probes for human cytochrome P450 enzymes: Recent progress and future perspectives, 2020, Coordination Chemistry Reviews
  • Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS, 2022, Circulation Research

Frequent collaborators in their work include Laura S. Van Winkle, Weiguo Han, Weizhu Yang, Yanhong Quan, and Xiaoyu Fan.

Best Publications

  • Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts*

    Xinxin Ding;Laurence S. Kaminsky

  • Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

    Ting Su;Ziping Bao;Qing-Yu Zhang;Theresa J. Smith

  • Liver-specific Deletion of the NADPH-Cytochrome P450 Reductase Gene: IMPACT ON PLASMA CHOLESTEROL HOMEOSTASIS AND THE FUNCTION AND REGULATION OF MICROSOMAL CYTOCHROME P450 AND HEME OXYGENASE *

    Jun Gu;Yan Weng;Qing Yu Zhang;Huadong Cui

  • Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

    Michael H. Court;Xiuling Zhang;Xinxin Ding;Karen K. Yee

  • An update on the role of intestinal cytochrome P450 enzymes in drug disposition

    Fang Xie;Xinxin Ding;Qing Yu Zhang

  • NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

    David S. Riddick;Xinxin Ding;C. Roland Wolf;Todd D. Porter

  • In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa.

    Jun Gu;Huadong Cui;Melissa Behr;Li Zhang

  • Metabolism of nicotine and cotinine by human cytochrome P450 2A13.

    Ziping Bao;Xiao Yang He;Xinxin Ding;Saileta Prabhu

  • Expression of CYP2A genes in rodent and human nasal mucosa.

    Ting Su;Jonathan J. Sheng;Jonathan J. Sheng;Thomas W. Lipinskas;Xinxin Ding;Xinxin Ding

  • Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP.

    Yinlan Bai;Jun Yang;Xin Zhou;Xin Zhou;Xinxin Ding;Xinxin Ding

  • Regulation of the cytochrome P450 2A genes.

    Ting Su;Xinxin Ding

  • CYP1B1 expression in human lung

    Simon D. Spivack;Gregory J. Hurteau;Andrew A. Reilly;Kenneth M. Aldous

  • Purification and Characterization of Heterologously Expressed Mouse CYP2A5 and CYP2G1: Role in Metabolic Activation of Acetaminophen and 2,6-Dichlorobenzonitrile in Mouse Olfactory Mucosal Microsomes

    Jun Gu;Qing Yu Zhang;Mary Beth Genter;Thomas W. Lipinskas

  • Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5-null Mouse Model

    Xin Zhou;Xiaoliang Zhuo;Fang Xie;Kerri Kluetzman

  • Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.

    Xiuling Zhang;Ting Su;Qing Yu Zhang;Jun Gu

  • Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa.

    Xiuling Zhang;Qing Yu Zhang;Dazhi Liu;Ting Su

  • Determination of the Role of Target Tissue Metabolism in Lung Carcinogenesis Using Conditional Cytochrome P450 Reductase-Null Mice

    Yan Weng;Cheng Fang;Robert J. Turesky;Melissa Behr

  • Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems.

    Miroslav Dostalek;Klarissa D. Hardy;Ginger L. Milne;Jason D. Morrow

  • Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity.

    Jun Gu;Ting Su;Ting Su;Ying Chen;Qing Yu Zhang

  • Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants.

    Cheng Liu;Xiaoliang Zhuo;Xiaoliang Zhuo;Frank J. Gonzalez;Xinxin Ding;Xinxin Ding;Xinxin Ding

Frequent Co-Authors

Yu Zhang
Yu Zhang Peking University
Yupo Ma
Yupo Ma Stony Brook University
Lindsay B. Hough
Lindsay B. Hough Albany Medical Center Hospital
Robert J. Turesky
Robert J. Turesky University of Minnesota
Minor J. Coon
Minor J. Coon University of Michigan–Ann Arbor
Daniel W. Nebert
Daniel W. Nebert University of Cincinnati
Kurunthachalam Kannan
Kurunthachalam Kannan University at Albany, State University of New York
Scott Zeitlin
Scott Zeitlin University of Virginia
Paul N. Black
Paul N. Black University of Nebraska–Lincoln

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