Colin J. Henderson

Overview

Best Publications

• Regulation of JNK signaling by GSTp

  Victor Adler;Zhimin Yin;Serge Y. Fuchs;Miriam Benezra

  1365
  Citations

• The Cap ‘n’ Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes

  Michael McMahon;Ken Itoh;Masayuki Yamamoto;Simon A. Chanas

  925
  Citations

• Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

  Simon A Chanas;Qing Jiang;Michael McMahon;Gail K McWalter

  588
  Citations

• Feedback control of AHR signalling regulates intestinal immunity.

  Chris Schiering;Emma Wincent;Amina Metidji;Andrea Iseppon

  542
  Citations

• Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo

  Valerie Stock;Linda Böhmert;Elisa Lisicki;Rafael Block

  475
  Citations

• Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases

  C J Henderson;A G Smith;J Ure;K Brown

  470
  Citations

• The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.

  J. D. Hayes;S. A. Chanas;C.J. Henderson;M. McMahon

  452
  Citations

• Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

  Xiu Jun Wang;John D. Hayes;Colin J. Henderson;C. Roland Wolf

  345
  Citations

• Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

  L M Forrester;C J Henderson;M J Glancey;D J Back

  301
  Citations

• Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.

  Gail K. McWalter;Larry G. Higgins;Lesley I. McLellan;Colin J. Henderson

  296
  Citations

• Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

  Colin J. Henderson;Diana M.E. Otto;Dianne Carrie;Mark A. Magnuson

  295
  Citations

• Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

  Shogo Takahashi;Tatsuki Fukami;Yusuke Masuo;Chad N. Brocker

  283
  Citations

• Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi

  Colin J. Henderson;C. Roland Wolf;Neil Kitteringham;Helen Powell

  267
  Citations

• Identification of P450 enzymes involved in metabolism of verapamil in humans.

  H K Kroemer;J C Gautier;P Beaune;C Henderson

  246
  Citations

• Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways

  J E Ruscoe;L A Rosario;T Wang;L Gate

  233
  Citations

• Identification of Novel Roles of the Cytochrome P450 System in Early Embryogenesis: Effects on Vasculogenesis and Retinoic Acid Homeostasis

  Diana M. E. Otto;Diana M. E. Otto;Colin J. Henderson;Dianne Carrie;Megan Davey

  207
  Citations

• High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

  Anne-Marie Camus;Olivier Geneste;Paavo Honkakoski;Jean-Claude Béréziat

  206
  Citations

• Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

  Jillian Ross;Simon M. Plummer;Anja Rode;Nico Scheer

  195
  Citations

• Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.

  Robert Elsby;Neil R. Kitteringham;Christopher E. Goldring;Cerys A. Lovatt

  184
  Citations

• Role of Hepatic Cytochrome P450s in the Pharmacokinetics and Toxicity of Cyclophosphamide: Studies with the Hepatic Cytochrome P450 Reductase Null Mouse

  Georgia J. Pass;Dianne Carrie;Michael Boylan;Sally Lorimore

  183
  Citations