World's Best Scientists 2026 revealed!
Masayuki Yamamoto

Masayuki Yamamoto

Award Badge
Best Scientists
2025
Award Badge
Medicine
Japan
2026

D-Index & Metrics

Best Scientists

D-Index
217
Citations
199639
World Ranking
151
National Ranking
4

Molecular Biology

D-Index
213
Citations
190350
World Ranking
13
National Ranking
2

Medicine

D-Index
216
Citations
197190
World Ranking
101
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Medicine in Japan Leader Award
  • 2026 - Research.com Molecular Biology in Japan Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in Japan Leader Award
  • 2025 - Research.com Molecular Biology in Japan Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Japan Leader Award
  • 2023 - Research.com Molecular Biology in Japan Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Masayuki Yamamoto is affiliated with Tohoku University in Japan and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology, Genetics, and Physiology. Their research also touches upon Cancer Research and Immunology.

The scientist's work spans several main topics, including:

  • Genomics, phytochemicals, and oxidative stress
  • Genetic Associations and Epidemiology
  • Glutathione Transferases and Polymorphisms
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Birth, Development, and Health
  • Pregnancy and preeclampsia studies

Recent publications by Masayuki Yamamoto include the following:

  • A cross-population atlas of genetic associations for 220 human phenotypes, 2021, Nature Genetics
  • Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology, 2022, Nature Reviews Molecular Cell Biology
  • The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway, 2020, Molecular and Cellular Biology
  • Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases, 2020, Nature Genetics
  • Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration, 2020, Cell

Masayuki Yamamoto frequently collaborates with other researchers in their field. Notable coauthors include:

  • Kengo Kinoshita
  • Gen Tamiya
  • Fumiki Katsuoka
  • Atsushi Hozawa
  • Shinichi Kuriyama

The scientist has published frequently in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular and Cellular Biology
  • Communications Biology
  • Redox Biology
  • Free Radical Biology and Medicine

Best Publications

  • AN NRF2/SMALL MAF HETERODIMER MEDIATES THE INDUCTION OF PHASE II DETOXIFYING ENZYME GENES THROUGH ANTIOXIDANT RESPONSE ELEMENTS

    Ken Itoh;Tomoki Chiba;Satoru Takahashi;Tetsuro Ishii

  • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

    Ken Itoh;Nobunao Wakabayashi;Yasutake Katoh;Tetsuro Ishii

  • Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

    Akira Kobayashi;Moon Il Kang;Hiromi Okawa;Makiko Ohtsuji

  • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

    Masaaki Komatsu;Hirofumi Kurokawa;Satoshi Waguri;Keiko Taguchi

  • Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

    Masaaki Komatsu;Satoshi Waguri;Masato Koike;Yu shin Sou;Yu shin Sou

  • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

    Albena T. Dinkova-Kostova;W. David Holtzclaw;Robert N. Cole;Ken Itoh

  • A cross-population atlas of genetic associations for 220 human phenotypes

    Saori Sakaue;Masahiro Kanai;Yosuke Tanigawa;Juha Karjalainen

  • Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

    Tetsuro Ishii;Ken Itoh;Satoru Takahashi;Hideyo Sato

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Nrf2-Keap1 defines a physiologically important stress response mechanism.

    Hozumi Motohashi;Masayuki Yamamoto

  • Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

    Keiko Taguchi;Hozumi Motohashi;Masayuki Yamamoto

  • Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

    Eri H. Kobayashi;Takafumi Suzuki;Ryo Funayama;Takeshi Nagashima

  • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

    Rajesh K. Thimmulappa;Kim H. Mai;Sorachai Srisuma;Thomas W. Kensler

  • Initial value/boundary value problems for fractional diffusion-wave equations and applications to some inverse problems

    Kenichi Sakamoto;Masahiro Yamamoto

  • Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

    Yoichiro Mitsuishi;Keiko Taguchi;Yukie Kawatani;Tatsuhiro Shibata

  • Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.

    Minerva Ramos-Gomez;Mi Kyoung Kwak;Patrick M. Dolan;Ken Itoh

  • The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

    Masayuki Yamamoto;Thomas W. Kensler;Hozumi Motohashi

  • Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

    Michael McMahon;Ken Itoh;Masayuki Yamamoto;John D. Hayes

  • Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation.

    Makoto Kobayashi;Masayuki Yamamoto

  • Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles

    Ken Itoh;Kit I Tong;Masayuki Yamamoto

Frequent Co-Authors

Hozumi Motohashi
Hozumi Motohashi Tohoku University
Ken Itoh
Ken Itoh Hirosaki University
Satoru Takahashi
Satoru Takahashi University of Tsukuba
James Douglas Engel
James Douglas Engel University of Michigan–Ann Arbor
Kengo Kinoshita
Kengo Kinoshita Tohoku University
Thomas W. Kensler
Thomas W. Kensler Johns Hopkins University
Kazuhiko Igarashi
Kazuhiko Igarashi Tohoku University
Mamoru Yamamoto
Mamoru Yamamoto Kyoto University
Yoshinori Watanabe
Yoshinori Watanabe University of Tokyo
Akira Kobayashi
Akira Kobayashi Doshisha University

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