D-Index & Metrics Best Publications
Research.com 2022 Best Scientist Award Badge
Molecular Biology
Japan
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Best Scientists D-index 197 Citations 159,368 1,861 World Ranking 215 National Ranking 4
Medicine D-index 190 Citations 140,760 1,549 World Ranking 138 National Ranking 4
Molecular Biology D-index 193 Citations 153,445 1,558 World Ranking 14 National Ranking 1

Research.com Recognitions

Awards & Achievements

2023 - Research.com Medicine in Japan Leader Award

2023 - Research.com Molecular Biology in Japan Leader Award

2022 - Research.com Best Scientist Award

2022 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Enzyme

Masayuki Yamamoto mainly focuses on Transcription factor, Biochemistry, Cell biology, Molecular biology and KEAP1. The concepts of his Transcription factor study are interwoven with issues in Regulation of gene expression and Transcription. His studies in Cell biology integrate themes in fields like Kelch-Like ECH-Associated Protein 1, Receptor, Oxidative phosphorylation and Autophagy.

The various areas that he examines in his Molecular biology study include Maf Transcription Factors, Gene expression, Transgene, Cellular differentiation and GCLM. His work focuses on many connections between KEAP1 and other disciplines, such as Cancer cell, that overlap with his field of interest in Cancer research. His Glutathione research focuses on Oxidative stress and how it connects with Immunology, Pathogenesis and Inflammation.

His most cited work include:

  • AN NRF2/SMALL MAF HETERODIMER MEDIATES THE INDUCTION OF PHASE II DETOXIFYING ENZYME GENES THROUGH ANTIOXIDANT RESPONSE ELEMENTS (2925 citations)
  • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain (2507 citations)
  • Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice (1625 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Cell biology, Molecular biology, Internal medicine, Transcription factor and Gene. His Cell biology research integrates issues from Schizosaccharomyces pombe, KEAP1, Biochemistry and Meiosis. His Molecular biology research is multidisciplinary, incorporating elements of Gene expression, Transgene, Cellular differentiation, Mutant and Regulation of gene expression.

His work deals with themes such as Gastroenterology, Endocrinology and Oncology, which intersect with Internal medicine. Gene is a subfield of Genetics that Masayuki Yamamoto investigates. His Oxidative stress research incorporates elements of Reactive oxygen species, Glutathione and Immunology.

He most often published in these fields:

  • Cell biology (25.79%)
  • Molecular biology (22.30%)
  • Internal medicine (15.79%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cell biology (25.79%)
  • Internal medicine (15.79%)
  • Cancer research (8.47%)

In recent papers he was focusing on the following fields of study:

Cell biology, Internal medicine, Cancer research, Genetics and KEAP1 are his primary areas of study. His Cell biology study combines topics from a wide range of disciplines, such as Schizosaccharomyces pombe, Mutant, Transcription factor, Downregulation and upregulation and Regulation of gene expression. His Schizosaccharomyces pombe study integrates concerns from other disciplines, such as Meiosis and Ploidy.

Internal medicine is frequently linked to Endocrinology in his study. His Cancer research research incorporates themes from Carcinogenesis, Cell culture and Haematopoiesis, GATA2. His Genetics study frequently draws parallels with other fields, such as Disease.

Between 2016 and 2021, his most popular works were:

  • The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis (338 citations)
  • The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis (338 citations)
  • Genome-wide association study identifies 112 new loci for body mass index in the Japanese population (197 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Enzyme

His main research concerns Cell biology, Oxidative stress, Transcription factor, KEAP1 and Cancer research. His work carried out in the field of Cell biology brings together such families of science as Inflammation, Schizosaccharomyces pombe, Regulation of gene expression and Oxidative phosphorylation. His research in Regulation of gene expression intersects with topics in Promoter and Molecular biology.

His research integrates issues of Autophagy, Reactive oxygen species and Pathology in his study of Oxidative stress. His Transcription factor research includes elements of Cancer cell, Ubiquitin, Ubiquitin ligase and Detoxification. His research investigates the connection between KEAP1 and topics such as Activator that intersect with issues in Osteoclast.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

AN NRF2/SMALL MAF HETERODIMER MEDIATES THE INDUCTION OF PHASE II DETOXIFYING ENZYME GENES THROUGH ANTIOXIDANT RESPONSE ELEMENTS

Ken Itoh;Tomoki Chiba;Satoru Takahashi;Tetsuro Ishii.
Biochemical and Biophysical Research Communications (1997)

4003 Citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh;Nobunao Wakabayashi;Yasutake Katoh;Tetsuro Ishii.
Genes & Development (1999)

3577 Citations

Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

Masaaki Komatsu;Satoshi Waguri;Masato Koike;Yu shin Sou;Yu shin Sou.
Cell (2007)

2194 Citations

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi;Moon Il Kang;Hiromi Okawa;Makiko Ohtsuji.
Molecular and Cellular Biology (2004)

2147 Citations

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Tetsuro Ishii;Ken Itoh;Satoru Takahashi;Hideyo Sato.
Journal of Biological Chemistry (2000)

2012 Citations

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Masaaki Komatsu;Hirofumi Kurokawa;Satoshi Waguri;Keiko Taguchi.
Nature Cell Biology (2010)

1989 Citations

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova-Kostova;W. David Holtzclaw;Robert N. Cole;Ken Itoh.
Proceedings of the National Academy of Sciences of the United States of America (2002)

1977 Citations

Nrf2-Keap1 defines a physiologically important stress response mechanism.

Hozumi Motohashi;Masayuki Yamamoto.
Trends in Molecular Medicine (2004)

1770 Citations

Essential Bacillus subtilis genes

K. Kobayashi;S.D. Ehrlich;A. Albertini;G. Amati.
Proceedings of the National Academy of Sciences of the United States of America (2003)

1624 Citations

A promoter-level mammalian expression atlas

Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie.
Nature (2014)

1550 Citations

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