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Hozumi Motohashi

Hozumi Motohashi

D-Index & Metrics

Molecular Biology

D-Index
79
Citations
34882
World Ranking
1024
National Ranking
78

Overview

Hozumi Motohashi is affiliated with Tohoku University in Japan and has an extensive publication record in the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans several subfields, prominently including molecular biology, biochemistry, physiology, cancer research, and epidemiology.

The scientist's work covers multiple topics, with particular focus on:

  • Genomics, phytochemicals, and oxidative stress
  • Sulfur compounds in biology
  • Glutathione transferases and polymorphisms
  • RNA modifications and cancer
  • Redox biology and oxidative stress
  • Coenzyme Q10 studies and effects
  • Autophagy in disease and therapy

Hozumi Motohashi has contributed to research published in various scientific venues. The most frequent publication venues include:

  • Free Radical Biology and Medicine
  • Redox Biology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Biochemistry

Recent representative publications by Motohashi include:

  • "p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response," 2021, Nature Communications
  • "Ferroptosis in health and disease," 2024, Redox Biology
  • "Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study," 2020, Journal of Epidemiology
  • "Sulfide catabolism ameliorates hypoxic brain injury," 2021, Nature Communications
  • "Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers," 2020, Nature Communications

The scientist has collaborated frequently with several researchers, including:

  • Takaaki Akaike
  • Hiroki Sekine
  • Masanobu Morita
  • Shohei Murakami
  • Tetsuro Matsunaga

Best Publications

  • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

    Masaaki Komatsu;Hirofumi Kurokawa;Satoshi Waguri;Keiko Taguchi

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Nrf2-Keap1 defines a physiologically important stress response mechanism.

    Hozumi Motohashi;Masayuki Yamamoto

  • Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

    Keiko Taguchi;Hozumi Motohashi;Masayuki Yamamoto

  • Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

    Eri H. Kobayashi;Takafumi Suzuki;Ryo Funayama;Takeshi Nagashima

  • Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

    Yoichiro Mitsuishi;Keiko Taguchi;Yukie Kawatani;Tatsuhiro Shibata

  • The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

    Masayuki Yamamoto;Thomas W. Kensler;Hozumi Motohashi

  • Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

    Yoshinobu Ichimura;Satoshi Waguri;Yu shin Sou;Shun Kageyama

  • Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

    Nobunao Wakabayashi;Ken Itoh;Junko Wakabayashi;Hozumi Motohashi

  • Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.

    Tomoaki Ida;Tomohiro Sawa;Hideshi Ihara;Yukihiro Tsuchiya

  • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.

    Mi Kyoung Kwak;Nobunao Wakabayashi;Nobunao Wakabayashi;Ken Itoh;Hozumi Motohashi

  • Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.

    Tatsuya Oyake;Ken Itoh;Hozumi Motohashi;Norio Hayashi

  • Toward clinical application of the Keap1–Nrf2 pathway

    Takafumi Suzuki;Hozumi Motohashi;Masayuki Yamamoto

  • Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.

    Tae Yamamoto;Takafumi Suzuki;Akira Kobayashi;Junko Wakabayashi

  • Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors.

    Hozumi Motohashi;Tania O'Connor;Fumiki Katsuoka;James Douglas Engel

  • Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

    Takaaki Akaike;Tomoaki Ida;Fan-Yan Wei;Motohiro Nishida;Motohiro Nishida

  • Keap1 degradation by autophagy for the maintenance of redox homeostasis

    Keiko Taguchi;Nanako Fujikawa;Masaaki Komatsu;Tetsuro Ishii

  • Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

    Hiromi Okawa;Hozumi Motohashi;Akira Kobayashi;Hiroyuki Aburatani

  • The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

    Yoichiro Mitsuishi;Hozumi Motohashi;Masayuki Yamamoto

  • Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway

    Hozumi Motohashi;Fumiki Katsuoka;James Douglas Engel;Masayuki Yamamoto

Frequent Co-Authors

Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Takaaki Akaike
Takaaki Akaike Tohoku University
James Douglas Engel
James Douglas Engel University of Michigan–Ann Arbor
Kazuhiko Igarashi
Kazuhiko Igarashi Tohoku University
Masaaki Komatsu
Masaaki Komatsu Juntendo University
Motohiro Nishida
Motohiro Nishida Kyushu University
Satoru Takahashi
Satoru Takahashi University of Tsukuba
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Kengo Kinoshita
Kengo Kinoshita Tohoku University
Takashi Suzuki
Takashi Suzuki Tohoku University

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