World's Best Scientists 2026 revealed!
Masaaki Komatsu

Masaaki Komatsu

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
112
Citations
102868
World Ranking
876
National Ranking
41

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Masaaki Komatsu is affiliated with Juntendo University in Japan, contributing extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research has a strong focus on molecular and cellular biology, with numerous publications investigating autophagy, oxidative stress, and related cellular processes.

Their recent published papers include:

  • International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis, 2024, Autophagy
  • p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response, 2021, Nature Communications
  • Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes, 2021, Journal for ImmunoTherapy of Cancer
  • LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury, 2020, Nature Cell Biology
  • NBR 1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system, 2020, EMBO Reports

Their frequent co-authors include:

  • Shun Kageyama
  • Yoshinobu Ichimura
  • Nobuo N. Noda
  • Satoshi Waguri
  • Satoko Komatsu-Hirota

Their publications often appear in established venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Autophagy
  • Journal of Investigative Dermatology
  • American Journal of Transplantation

The main fields of study covered by Masaaki Komatsu encompass biochemistry, genetics, molecular biology (with 84 publications) and medicine (68 publications). The scientist's subfields of study include molecular biology (60 publications), epidemiology (31), physiology (11), cell biology (11), and genetics (10).

The core research topics focus on autophagy in disease and therapy (58 publications), genomics, phytochemicals, and oxidative stress (22), endoplasmic reticulum stress and disease (20), epigenetics and DNA methylation (12), RNA modifications and cancer (12), ubiquitin and proteasome pathways (12), and amyotrophic lateral sclerosis research (10).

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Autophagy: Renovation of Cells and Tissues

    Noboru Mizushima;Masaaki Komatsu

  • Loss of autophagy in the central nervous system causes neurodegeneration in mice

    Masaaki Komatsu;Satoshi Waguri;Satoshi Waguri;Tomoki Chiba;Shigeo Murata

  • Autophagy regulates lipid metabolism

    Rajat Singh;Susmita Kaushik;Yongjun Wang;Youqing Xiang

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

    Masaaki Komatsu;Satoshi Waguri;Takashi Ueno;Junichi Iwata

  • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

    Masaaki Komatsu;Hirofumi Kurokawa;Satoshi Waguri;Keiko Taguchi

  • Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

    Masaaki Komatsu;Satoshi Waguri;Masato Koike;Yu shin Sou;Yu shin Sou

  • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

    Tatsuya Saitoh;Naonobu Fujita;Myoung Ho Jang;Satoshi Uematsu

  • PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

    Noriyuki Matsuda;Shigeto Sato;Kahori Shiba;Kei Okatsu

  • Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

    Miguel A. Sanjuan;Christopher P. Dillon;Stephen W. G. Tait;Simon Moshiach

  • Autophagy-deficient mice develop multiple liver tumors

    Akito Takamura;Masaaki Komatsu;Taichi Hara;Ayako Sakamoto

  • Autophagy Is Required to Maintain Muscle Mass

    Eva Masiero;Lisa Agatea;Cristina Mammucari;Bert Blaauw

  • A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

    Vladimir Kirkin;Trond Lamark;Yu Shin Sou;Geir Bjørkøy

  • Discovery of Atg5/Atg7-independent alternative macroautophagy

    Yuya Nishida;Satoko Arakawa;Kenji Fujitani;Hirofumi Yamaguchi

  • Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

    Yoshinobu Ichimura;Satoshi Waguri;Yu shin Sou;Shun Kageyama

  • Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

    Chie Ebato;Toyoyoshi Uchida;Masayuki Arakawa;Masaaki Komatsu;Masaaki Komatsu;Masaaki Komatsu

  • Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

    Yoshinobu Ichimura;Taichi Kumanomidou;Yu-shin Sou;Yu-shin Sou;Tsunehiro Mizushima

Frequent Co-Authors

Keiji Tanaka
Keiji Tanaka Tokyo Metropolitan Institute of Medical Science
Takashi Ueno
Takashi Ueno Juntendo University
Eiki Kominami
Eiki Kominami Juntendo University
Satoshi Waguri
Satoshi Waguri Fukushima Medical University
Yasuo Uchiyama
Yasuo Uchiyama Juntendo University
Isei Tanida
Isei Tanida Juntendo University
Noboru Mizushima
Noboru Mizushima University of Tokyo
Masato Koike
Masato Koike Juntendo University
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Myung-Shik Lee
Myung-Shik Lee Yonsei University

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