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Biology and Biochemistry
Japan
2026

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Biology and Biochemistry

D-Index
161
Citations
130124
World Ranking
122
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2022 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2011 - Keio Medical Science Prize, Keio University, Tokyo, Japan

Overview

Keiji Tanaka is a researcher affiliated with the Tokyo Metropolitan Institute of Medical Science in Japan. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on Molecular Biology, Cell Biology, Epidemiology, Neurology, and Immunology.

Their research topics include:

  • Ubiquitin and proteasome pathways
  • Endoplasmic reticulum stress and disease
  • Autophagy in disease and therapy
  • Interferon and immune responses
  • Parkinson's disease mechanisms and treatments
  • Protein degradation and inhibitors
  • NF-κB signaling pathways

Among their recent publications are:

  • "Stress- and ubiquitylation-dependent phase separation of the proteasome", 2020, Nature
  • "Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy", 2020, The Journal of Cell Biology
  • "Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation", 2020, Nature Communications
  • "The PINK1-Parkin axis: An Overview", 2020, Neuroscience Research
  • "TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains", 2021, Molecular Cell

Keiji Tanaka has frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), The Journal of Cell Biology, Molecular Cell, Communications Biology, and Nature.

They have collaborated extensively with coauthors including Yasushi Saeki, Akinori Endo, Fumiaki Ohtake, Koji Yamano, and Noriyuki Matsuda.

Keiji Tanaka received the Keio Medical Science Prize from Keio University, Tokyo, Japan, in 2011.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Loss of autophagy in the central nervous system causes neurodegeneration in mice

    Masaaki Komatsu;Satoshi Waguri;Satoshi Waguri;Tomoki Chiba;Shigeo Murata

  • Autophagy regulates lipid metabolism

    Rajat Singh;Susmita Kaushik;Yongjun Wang;Youqing Xiang

  • Structure and Functions of the 20S and 26S Proteasomes

    Olivier Coux;Keiji Tanaka;Alfred L. Goldberg

  • Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

    Hideki Shimura;Nobutaka Hattori;Shin-ichiro Kubo;Yoshikuni Mizuno

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

    Masaaki Komatsu;Satoshi Waguri;Takashi Ueno;Junichi Iwata

  • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

    Masaaki Komatsu;Hirofumi Kurokawa;Satoshi Waguri;Keiko Taguchi

  • Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

    Masaaki Komatsu;Satoshi Waguri;Masato Koike;Yu shin Sou;Yu shin Sou

  • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

    Tatsuya Saitoh;Naonobu Fujita;Myoung Ho Jang;Satoshi Uematsu

  • PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

    Noriyuki Matsuda;Shigeto Sato;Kahori Shiba;Kei Okatsu

  • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.

    Hiroshi Takayanagi;Kouetsu Ogasawara;Shigeaki Hida;Tomoki Chiba

  • Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

    Miguel A. Sanjuan;Christopher P. Dillon;Stephen W. G. Tait;Simon Moshiach

  • Ubiquitin is phosphorylated by PINK1 to activate parkin

    Fumika Koyano;Kei Okatsu;Kei Okatsu;Hidetaka Kosako;Yasushi Tamura

  • Autophagy-deficient mice develop multiple liver tumors

    Akito Takamura;Masaaki Komatsu;Taichi Hara;Ayako Sakamoto

  • Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.

    Takanori Ebisawa;Minoru Fukuchi;Gyo Murakami;Tomoki Chiba

  • Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

    Yoshinobu Ichimura;Satoshi Waguri;Yu shin Sou;Shun Kageyama

  • Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

    Fuminori Tokunaga;Shin-ichi Sakata;Shin-ichi Sakata;Yasushi Saeki;Yoshinori Satomi

  • Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

    Chie Ebato;Toyoyoshi Uchida;Masayuki Arakawa;Masaaki Komatsu;Masaaki Komatsu;Masaaki Komatsu

Frequent Co-Authors

Masaaki Komatsu
Masaaki Komatsu Juntendo University
Shigeo Murata
Shigeo Murata University of Tokyo
Yasushi Saeki
Yasushi Saeki Tokyo Metropolitan Institute of Medical Science
Tomoki Chiba
Tomoki Chiba University of Tsukuba
Akira Ichihara
Akira Ichihara University of Tokushima
Koichi Kato
Koichi Kato National Institutes of Natural Sciences
Chin Ha Chung
Chin Ha Chung Seoul National University
Eiki Kominami
Eiki Kominami Juntendo University
Takashi Ueno
Takashi Ueno Juntendo University
Kazuhiro Iwai
Kazuhiro Iwai Kyoto University

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