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Shigeo Murata

Shigeo Murata

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
26575
World Ranking
8454
National Ranking
565

Overview

Shigeo Murata is affiliated with the University of Tokyo in Japan and specializes in Biochemistry, Genetics and Molecular Biology. Their research notably focuses on Molecular Biology, with significant contributions also in Cell Biology, Epidemiology, Immunology, and Pharmaceutical Science. The scientist has investigated topics such as Ubiquitin and proteasome pathways, Endoplasmic Reticulum Stress and Disease, Autophagy in Disease and Therapy, Glycosylation and Glycoproteins Research, Galectins and Cancer Biology, Histone Deacetylase Inhibitors Research, and Chemical Reactions and Isotopes.

Murata's recent papers include the following:

  • Stress- and ubiquitylation-dependent phase separation of the proteasome, 2020, Nature
  • NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein, 2020, Molecular and Cellular Biology
  • ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond, 2020, International Journal of Molecular Sciences
  • Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency, 2021, Nature Communications
  • The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation, 2021, iScience

The scientist has frequently published in journals such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Molecular and Cellular Biology, iScience, and Angewandte Chemie International Edition.

Among frequent collaborators are Jun Hamazaki, Shoshiro Hirayama, Kohei Watanabe, Ryo Takita, and Ayako Watanabe. These co-authors have contributed with Murata on various studies, reflecting a collaborative approach in their research environment.

Best Publications

  • Loss of autophagy in the central nervous system causes neurodegeneration in mice

    Masaaki Komatsu;Satoshi Waguri;Satoshi Waguri;Tomoki Chiba;Shigeo Murata

  • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

    Masaaki Komatsu;Satoshi Waguri;Takashi Ueno;Junichi Iwata

  • Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

    Masaaki Komatsu;Satoshi Waguri;Masato Koike;Yu shin Sou;Yu shin Sou

  • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.

    Hiroshi Takayanagi;Kouetsu Ogasawara;Shigeaki Hida;Tomoki Chiba

  • Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

    Fuminori Tokunaga;Shin-ichi Sakata;Shin-ichi Sakata;Yasushi Saeki;Yoshinori Satomi

  • A ubiquitin ligase complex assembles linear polyubiquitin chains

    Takayoshi Kirisako;Kiyoko Kamei;Shigeo Murata;Shigeo Murata;Michiko Kato

  • Regulation of CD8+ T Cell Development by Thymus-Specific Proteasomes

    Shigeo Murata;Katsuhiro Sasaki;Toshihiko Kishimoto;Shin-ichiro Niwa

  • CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein.

    Shigeo Murata;Yasufumi Minami;Michiko Minami;Tomoki Chiba

  • Molecular mechanisms of proteasome assembly

    Shigeo Murata;Hideki Yashiroda;Keiji Tanaka

  • Co-chaperone CHIP Associates with Expanded Polyglutamine Protein and Promotes Their Degradation by Proteasomes

    Nihar Ranjan Jana;Priyanka Dikshit;Anand Goswami;Svetlana Kotliarova

  • Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome

    Kazuhiko Arima;Akira Kinoshita;Hiroyuki Mishima;Nobuo Kanazawa

  • A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

    Akiko Kitamura;Yoichi Maekawa;Hisanori Uehara;Keisuke Izumi

  • Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process.

    Ayako Tonoki;Erina Kuranaga;Takeyasu Tomioka;Jun Hamazaki

  • A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes

    Yuko Hirano;Klavs B. Hendil;Hideki Yashiroda;Shun-ichiro Iemura

  • A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.

    Jun Hamazaki;Jun Hamazaki;Shun-ichiro Iemura;Tohru Natsume;Hideki Yashiroda

  • The immunoproteasome and thymoproteasome: functions, evolution and human disease.

    Shigeo Murata;Yousuke Takahama;Masanori Kasahara;Keiji Tanaka

  • Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.

    Takeumi Kaneko;Jun Hamazaki;Shun-ichiro Iemura;Katsuhiro Sasaki

  • CHIP: a quality-control E3 ligase collaborating with molecular chaperones.

    Shigeo Murata;Tomoki Chiba;Keiji Tanaka

  • Critical role of PA28γ in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis

    Kohji Moriishi;Rika Mochizuki;Kyoji Moriya;Hironobu Miyamoto

  • Stress- and ubiquitylation-dependent phase separation of the proteasome

    Sayaka Yasuda;Hikaru Tsuchiya;Ai Kaiho;Qiang Guo

Frequent Co-Authors

Keiji Tanaka
Keiji Tanaka Tokyo Metropolitan Institute of Medical Science
Yousuke Takahama
Yousuke Takahama National Institutes of Health
Tomoki Chiba
Tomoki Chiba University of Tsukuba
Masanori Kasahara
Masanori Kasahara Hokkaido University
Tohru Natsume
Tohru Natsume National Institute of Advanced Industrial Science and Technology
Shun-ichiro Iemura
Shun-ichiro Iemura Fukushima Medical University
Koichi Kato
Koichi Kato National Institutes of Natural Sciences
Kazuhiro Iwai
Kazuhiro Iwai Kyoto University
Yasushi Saeki
Yasushi Saeki Tokyo Metropolitan Institute of Medical Science

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