World's Best Scientists 2026 revealed!
Hiroshi Takayanagi

Hiroshi Takayanagi

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
45294
World Ranking
1966
National Ranking
112

Hiroshi Takayanagi publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Hiroshi Takayanagi sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 270 publications — 72nd percentile

72% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Hiroshi Takayanagi D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Hiroshi Takayanagi sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 94 D-Index — 90th percentile

90% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Hiroshi Takayanagi is affiliated with the University of Tokyo in Japan. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Within these broader domains, they focus on subfields such as Immunology, Molecular Biology, Oncology, Rheumatology, and Genetics.

The main topics of Takayanagi's work include:

  • Bone Metabolism and Diseases
  • T-cell and B-cell Immunology
  • Immune Response and Inflammation
  • Bone health and treatments
  • Immune Cell Function and Interaction
  • Cytokine Signaling Pathways and Interactions
  • Inflammasome and immune disorders

Takayanagi has authored papers in a variety of scientific journals. Some of the recent notable papers include:

  • "Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions," 2022, Nature Reviews Rheumatology
  • "Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells," 2020, EBioMedicine
  • "RANKL as the master regulator of osteoclast differentiation," 2021, Journal of Bone and Mineral Metabolism
  • "Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution," 2020, Nature Metabolism
  • "OPG Production Matters Where It Happened," 2020, Cell Reports

Frequent publication venues for Takayanagi include:

  • Nature Communications
  • Nature Immunology
  • Journal of Clinical Investigation
  • Inflammation and Regeneration
  • International Immunology

Collaborative work is a key feature of Takayanagi's research activities. Frequent coauthors include:

  • Masayuki Tsukasaki
  • Kazuo Okamoto
  • Ryunosuke Muro
  • Takeshi Nitta
  • Noriko Komatsu

Best Publications

  • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

    Hiroshi Takayanagi;Sunhwa Kim;Takako Koga;Takako Koga;Hiroshi Nishina

  • Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

    Hiroshi Takayanagi

  • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

    Kojiro Sato;Ayako Suematsu;Kazuo Okamoto;Akira Yamaguchi

  • Evidence for osteocyte regulation of bone homeostasis through RANKL expression

    Tomoki Nakashima;Mikihito Hayashi;Takanobu Fukunaga;Kosaku Kurata

  • The molecular understanding of osteoclast differentiation.

    Masataka Asagiri;Hiroshi Takayanagi

  • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.

    Hiroshi Takayanagi;Kouetsu Ogasawara;Shigeaki Hida;Tomoki Chiba

  • Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.

    Noriko Komatsu;Kazuo Okamoto;Shinichiro Sawa;Tomoki Nakashima

  • Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

    Takashi Nakamura;Yuuki Imai;Yuuki Imai;Takahiro Matsumoto;Shingo Sato

  • Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

    Takako Koga;Masanori Inui;Kazuya Inoue;Sunhwa Kim

  • Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.

    Masataka Asagiri;Kojiro Sato;Takako Usami;Sae Ochi

  • Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis

    Hiroshi Takayanagi;Hideharu Iizuka;Takuo Juji;Takumi Nakagawa

  • RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon - β

    Hiroshi Takayanagi;Sunhwa Kim;Koichi Matsuo;Hiroshi Suzuki

  • Osteoprotection by semaphorin 3A

    Mikihito Hayashi;Tomoki Nakashima;Masahiko Taniguchi;Tatsuhiko Kodama

  • Osteoimmunology: evolving concepts in bone–immune interactions in health and disease

    Masayuki Tsukasaki;Hiroshi Takayanagi

  • The role of NFAT in osteoclast formation.

    Hiroshi Takayanagi

  • The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

    Taishin Akiyama;Yusuke Shimo;Hiromi Yanai;Junwen Qin

  • Osteoimmunology and the effects of the immune system on bone

    Hiroshi Takayanagi

  • Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1 *

    Masahito Matsumoto;Masakazu Kogawa;Seiki Wada;Hiroshi Takayanagi

  • NFAT and Osterix cooperatively regulate bone formation

    Takako Koga;Yuichi Matsui;Masataka Asagiri;Tatsuhiko Kodama

  • Mechanistic insight into osteoclast differentiation in osteoimmunology.

    Hiroshi Takayanagi

Frequent Co-Authors

Tomoki Nakashima
Tomoki Nakashima Tokyo Medical and Dental University
Sakae Tanaka
Sakae Tanaka University of Tokyo
Tatsuhiko Kodama
Tatsuhiko Kodama University of Tokyo
Tadatsugu Taniguchi
Tadatsugu Taniguchi University of Tokyo
Kozo Nakamura
Kozo Nakamura Shinshu University
Shigeaki Kato
Shigeaki Kato University of Tokyo
Josef M. Penninger
Josef M. Penninger University of British Columbia
Yongwon Choi
Yongwon Choi University of Pennsylvania
Jun-ichiro Inoue
Jun-ichiro Inoue University of Tokyo
Yasuyuki Morishita
Yasuyuki Morishita University of Tokyo

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