D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 86 Citations 36,465 228 World Ranking 1866 National Ranking 112

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cytokine
  • Immune system

His primary areas of study are Osteoclast, Cell biology, RANKL, Osteoimmunology and Signal transduction. Hiroshi Takayanagi combines subjects such as Cellular differentiation, Transcription factor, NFAT, NFATC Transcription Factors and Bone regeneration with his study of Osteoclast. He interconnects Internal medicine, Bone remodeling, Endocrinology and Immunology in the investigation of issues within Cell biology.

His study in Immunology is interdisciplinary in nature, drawing from both Receptor, Bone resorption and CD40. His RANKL research incorporates elements of Macrophage colony-stimulating factor, Osteoprotegerin and Cytokine. Hiroshi Takayanagi focuses mostly in the field of Signal transduction, narrowing it down to matters related to Cancer research and, in some cases, Arthritis, Autoimmune disease, Experimental autoimmune encephalomyelitis and Mitogen-activated protein kinase kinase.

His most cited work include:

  • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. (1856 citations)
  • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. (1856 citations)
  • Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems (1208 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Cell biology, RANKL, Osteoclast, Immunology and Osteoimmunology. His work in Cell biology covers topics such as RANK Ligand which are related to areas like Fc receptor. His biological study spans a wide range of topics, including Cancer research, Signal transduction and Cytokine.

He combines subjects such as Endocrinology, Bone resorption, Transcription factor and Cellular differentiation with his study of Osteoclast. As part of one scientific family, Hiroshi Takayanagi deals mainly with the area of Bone resorption, narrowing it down to issues related to the Bone remodeling, and often Bone remodeling period. His research integrates issues of Cell signaling, Neuroscience, Immunity and Monocyte in his study of Osteoimmunology.

He most often published in these fields:

  • Cell biology (49.58%)
  • RANKL (48.74%)
  • Osteoclast (48.74%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cell biology (49.58%)
  • RANKL (48.74%)
  • Immune system (26.05%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Cell biology, RANKL, Immune system, Osteoclast and Inflammation. Hiroshi Takayanagi is interested in Signal transduction, which is a field of Cell biology. Hiroshi Takayanagi does research in RANKL, focusing on Osteoimmunology specifically.

As part of the same scientific family, Hiroshi Takayanagi usually focuses on Osteoimmunology, concentrating on Neuroscience and intersecting with Chemokine, Cell signaling and Haematopoiesis. His Immune system research is multidisciplinary, incorporating elements of Bone cell and Bone remodeling. His Osteoclast study combines topics from a wide range of disciplines, such as Osteoprotegerin and Endocrinology.

Between 2016 and 2021, his most popular works were:

  • Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems (139 citations)
  • Osteoimmunology: evolving concepts in bone-immune interactions in health and disease. (96 citations)
  • The Mechanisms of T Cell Selection in the Thymus (89 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Cytokine

His scientific interests lie mostly in RANKL, Immune system, Bone cell, Osteoimmunology and Bone remodeling. His studies in RANKL integrate themes in fields like Osteoclast and Cancer research. His Osteoclast study incorporates themes from Carcinogenesis, Endocrinology, Melanoma and Stromal cell.

His work carried out in the field of Immune system brings together such families of science as Periodontitis and Neuroscience. As a part of the same scientific family, Hiroshi Takayanagi mostly works in the field of Osteoimmunology, focusing on Bone marrow and, on occasion, CD14. The various areas that Hiroshi Takayanagi examines in his Receptor study include Immunohistochemistry, Dental alveolus, Osteocyte, Bone resorption and Cell biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

Hiroshi Takayanagi;Sunhwa Kim;Takako Koga;Takako Koga;Hiroshi Nishina.
Developmental Cell (2002)

2522 Citations

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

Hiroshi Takayanagi.
Nature Reviews Immunology (2007)

1958 Citations

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Kojiro Sato;Ayako Suematsu;Kazuo Okamoto;Akira Yamaguchi.
Journal of Experimental Medicine (2006)

1631 Citations

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Tomoki Nakashima;Mikihito Hayashi;Takanobu Fukunaga;Kosaku Kurata.
Nature Medicine (2011)

1609 Citations

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.

Hiroshi Takayanagi;Kouetsu Ogasawara;Shigeaki Hida;Tomoki Chiba.
Nature (2000)

1467 Citations

The molecular understanding of osteoclast differentiation.

Masataka Asagiri;Hiroshi Takayanagi.
Bone (2007)

1436 Citations

Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

Takashi Nakamura;Yuuki Imai;Yuuki Imai;Takahiro Matsumoto;Shingo Sato.
Cell (2007)

1203 Citations

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.

Noriko Komatsu;Kazuo Okamoto;Shinichiro Sawa;Tomoki Nakashima.
Nature Medicine (2014)

1081 Citations

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

Takako Koga;Masanori Inui;Kazuya Inoue;Sunhwa Kim.
Nature (2004)

1064 Citations

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.

Masataka Asagiri;Kojiro Sato;Takako Usami;Sae Ochi.
Journal of Experimental Medicine (2005)

860 Citations

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