Hiroshi Takayanagi

Overview

Best Publications

• Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

  Hiroshi Takayanagi;Sunhwa Kim;Takako Koga;Takako Koga;Hiroshi Nishina

  2845
  Citations

• Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

  Hiroshi Takayanagi

  2353
  Citations

• Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

  Kojiro Sato;Ayako Suematsu;Kazuo Okamoto;Akira Yamaguchi

  1869
  Citations

• Evidence for osteocyte regulation of bone homeostasis through RANKL expression

  Tomoki Nakashima;Mikihito Hayashi;Takanobu Fukunaga;Kosaku Kurata

  1839
  Citations

• The molecular understanding of osteoclast differentiation.

  Masataka Asagiri;Hiroshi Takayanagi

  1739
  Citations

• T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.

  Hiroshi Takayanagi;Kouetsu Ogasawara;Shigeaki Hida;Tomoki Chiba

  1564
  Citations

• Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.

  Noriko Komatsu;Kazuo Okamoto;Shinichiro Sawa;Tomoki Nakashima

  1402
  Citations

• Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

  Takashi Nakamura;Yuuki Imai;Yuuki Imai;Takahiro Matsumoto;Shingo Sato

  1308
  Citations

• Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

  Takako Koga;Masanori Inui;Kazuya Inoue;Sunhwa Kim

  1169
  Citations

• Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.

  Masataka Asagiri;Kojiro Sato;Takako Usami;Sae Ochi

  980
  Citations

• Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis

  Hiroshi Takayanagi;Hideharu Iizuka;Takuo Juji;Takumi Nakagawa

  856
  Citations

• RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon - β

  Hiroshi Takayanagi;Sunhwa Kim;Koichi Matsuo;Hiroshi Suzuki

  818
  Citations

• Osteoprotection by semaphorin 3A

  Mikihito Hayashi;Tomoki Nakashima;Masahiko Taniguchi;Tatsuhiko Kodama

  738
  Citations

• Osteoimmunology: evolving concepts in bone–immune interactions in health and disease

  Masayuki Tsukasaki;Hiroshi Takayanagi

  590
  Citations

• The role of NFAT in osteoclast formation.

  Hiroshi Takayanagi

  583
  Citations

• The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

  Taishin Akiyama;Yusuke Shimo;Hiromi Yanai;Junwen Qin

  581
  Citations

• Osteoimmunology and the effects of the immune system on bone

  Hiroshi Takayanagi

  574
  Citations

• Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1 *

  Masahito Matsumoto;Masakazu Kogawa;Seiki Wada;Hiroshi Takayanagi

  571
  Citations

• NFAT and Osterix cooperatively regulate bone formation

  Takako Koga;Yuichi Matsui;Masataka Asagiri;Tatsuhiko Kodama

  562
  Citations

• Mechanistic insight into osteoclast differentiation in osteoimmunology.

  Hiroshi Takayanagi

  557
  Citations