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Medicine

D-Index
91
Citations
42666
World Ranking
11561
National Ranking
5932

Overview

Brendan F. Boyce is affiliated with the University of Rochester Medical Center in the United States. Their research spans several key areas within medicine and biochemistry, genetics, and molecular biology, with a focus on topics related to bone health, immune function, and arthritis pathology.

Their main fields of study include Medicine, with 93 publications, and Biochemistry, Genetics and Molecular Biology, with 45 publications. Subfields reflect interests in Molecular Biology, Oncology, Immunology, Rheumatology, and Cancer Research. Specific topics addressed in their work encompass Bone health and treatments, Bone Metabolism and Diseases, Bone Tumor Diagnosis and Treatments, Immune cells in cancer, Systemic Lupus Erythematosus Research, T-cell and B-cell Immunology, and Single-cell and spatial transcriptomics.

Boyce has authored multiple scholarly articles. Recent notable papers include:

  • Notch signalling drives synovial fibroblast identity and arthritis pathology, 2020, Nature
  • Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes, 2023, Nature
  • Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice, 2022, Journal of Clinical Investigation
  • Granzyme K activates the entire complement cascade, 2025, Nature
  • TNF Receptor-Associated Factor 6 Mediates TNFα-Induced Skeletal Muscle Atrophy in Mice During Aging, 2020, Journal of Bone and Mineral Research

Their frequent coauthors include Jennifer H. Anolik, Andrew Filer, Costantino Pitzalis, Deepak A. Rao, and Lianping Xing. Boyce's works are often published in the following venues:

  • Nature Communications (6 publications)
  • Nature (4 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (4 publications)
  • Journal of Bone and Mineral Research (2 publications)
  • Nature Genetics (2 publications)

Boyce's research addresses significant intersections of bone disease mechanisms and immune system function, including arthritis and fracture healing, as well as cancer-related immune cell behavior. Their contributions utilize approaches from molecular biology and single-cell transcriptomics to study these complex biological systems, reflecting an interdisciplinary methodology connecting skeletal biology and immunology.

Best Publications

  • Stimulation of bone formation in vitro and in rodents by statins.

    G. Mundy;R. Garrett;S. Harris;J. Chan

  • Functions of RANKL/RANK/OPG in bone modeling and remodeling.

    Brendan F. Boyce;Lianping Xing

  • Increased bone formation in osteocalcin-deficient mice

    Patricia Ducy;Christelle Desbois;Brendan Boyce;Gerald Pinero

  • Increased osteoclast development after estrogen loss: mediation by interleukin-6

    Robert L. Jilka;Giao Hangoc;Giuseppe Girasole;Giovanni Passeri

  • Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

    David E. Hughes;Kenneth R. Wright;Harry L. Uy;Harry L. Uy;Akira Sasaki

  • Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

    Fan Zhang;Kevin Wei;Kamil Slowikowski;Chamith Y Fonseka

  • Requirement for NF-κB in osteoclast and B-cell development

    Guido Franzoso;Louise Carlson;Lianping Xing;Ljiljana Poljak

  • Biology of RANK, RANKL, and osteoprotegerin.

    Brendan F Boyce;Lianping Xing

  • Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta.

    Davis E. Hughes;Aihua Dai;John C. Tiffee;He Hiu Li

  • Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

    I. R. Garrett;B. F. Boyce;R. O.C. Oreffo;L. Bonewald

  • Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.

    Theresa A. Guise;Juan Juan Yin;Suzanne D. Taylor;Yoshinari Kumagai

  • Metastatic Prostate Cancer in a Transgenic Mouse

    Jeffrey R. Gingrich;Roberto J. Barrios;Ronald A. Morton;Brendan F. Boyce

  • Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues

    Shuyuan Yeh;Meng Yin Tsai;Meng Yin Tsai;Qingquan Xu;Xiao Min Mu

  • Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice

    B F Boyce;T Yoneda;C Lowe;P Soriano

  • Bisphosphonate Risedronate Reduces Metastatic Human Breast Cancer Burden in Bone in Nude Mice

    Akira Sasaki;Brendan F. Boyce;Beryl Story;Kenneth R. Wright

  • Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.

    T Bellido;R L Jilka;B F Boyce;G Girasole

  • CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta.

    Roy Morello;Terry K. Bertin;Yuqing Chen;Yuqing Chen;John Hicks

  • Effects of Interleukin-1 on Bone Turnover in Normal Mice*

    B. F. Boyce;T. B. Aufdemorte;I. R. Garrett;A. J. P. Yates

  • A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates.

    A.M. Parfitt;G.R. Mundy;G.D. Roodman;D.E. Hughes

  • 92238400 Increased osteoclast development after estrogen loss: Mediation by interleukin-6

    R.L. Jilka;G. Hangoc;G. Girasole;G. Passeri

Frequent Co-Authors

Edward M. Schwarz
Edward M. Schwarz University of Rochester Medical Center
Gregory R. Mundy
Gregory R. Mundy Vanderbilt University
Toshiyuki Yoneda
Toshiyuki Yoneda Osaka University
Di Chen
Di Chen Chinese Academy of Sciences
Regis J. O'Keefe
Regis J. O'Keefe Washington University in St. Louis
Ignac Fogelman
Ignac Fogelman King's College London
Christopher T. Ritchlin
Christopher T. Ritchlin University of Rochester Medical Center
Michael J. Zuscik
Michael J. Zuscik University of Rochester
Colin R. Dunstan
Colin R. Dunstan University of Sydney
Lynda F. Bonewald
Lynda F. Bonewald Indiana University

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