World's Best Scientists 2026 revealed!

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Molecular Biology

D-Index
79
Citations
21841
World Ranking
1040
National Ranking
24

Biology and Biochemistry

D-Index
83
Citations
24626
World Ranking
3499
National Ranking
81

Overview

Jiake Xu is affiliated with the University of Western Australia in Australia. Their research predominantly lies within the fields of Medicine and Biochemistry, Genetics and Molecular Biology, addressing a wide spectrum of topics related to bone health, cancer mechanisms, and molecular biology.

The scientist has contributed extensively to multiple subfields including Molecular Biology, Oncology, Cancer Research, Orthopedics and Sports Medicine, and Surgery. This reflects a multidisciplinary approach emphasizing both fundamental biology and clinical implications.

The main research topics they have explored include:

  • Bone Metabolism and Diseases
  • Bone health and treatments
  • NF-κB Signaling Pathways
  • Bone and Joint Diseases
  • Cancer-related molecular mechanisms research
  • Bone health and osteoporosis research
  • Inflammatory mediators and NSAID effects

Jiake Xu has published in a variety of scientific journals, with frequent appearances in:

  • Journal of Cellular Physiology
  • Frontiers in Pharmacology
  • Frontiers in Cell and Developmental Biology
  • Biomedicine & Pharmacotherapy
  • Experimental Biology and Medicine

Their recent papers include:

  • "Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version)" (2020), Journal of Orthopaedic Translation
  • "Single-Cell Transcriptomics Reveals the Complexity of the Tumor Microenvironment of Treatment-Naive Osteosarcoma" (2021), Frontiers in Oncology
  • "STAT3 and its targeting inhibitors in osteosarcoma" (2020), Cell Proliferation
  • "Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts" (2020), International Journal of Biological Sciences
  • "m6A Methylation Regulates Osteoblastic Differentiation and Bone Remodeling" (2021), Frontiers in Cell and Developmental Biology

Collaboration is a significant aspect of Jiake Xu's research activities. Frequent coauthors include Jinmin Zhao, Yuangang Su, Jinbo Yuan, Qian Liu, and Kai Chen, indicating ongoing partnerships with researchers specializing in related biomedical fields.

Best Publications

  • Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies.

    Qiang Guo;Yuxiang Wang;Dan Xu;Johannes Nossent

  • An overview of the regulation of bone remodelling at the cellular level

    Jasreen Kular;Jennifer Tickner;Shek Man Chim;Jiake Xu

  • Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

    Defang Li;Jin Liu;Baosheng Guo;Chao Liang

  • Porcine small intestine submucosa (SIS) is not an acellular collagenous matrix and contains porcine DNA: Possible implications in human implantation

    M. H. Zheng;J. Chen;Y. Kirilak;C. Willers

  • Current research on pharmacologic and regenerative therapies for osteoarthritis.

    Wei Zhang;Hongwei Ouyang;Crispin R Dass;Jiake Xu

  • Human cytomegalovirus latent gene expression in granulocyte-macrophage progenitors in culture and in seropositive individuals.

    Kazuhiro Kondo;Jiake Xu;Edward S. Mocarski

  • Scaffolds for tendon and ligament repair: review of the efficacy of commercial products.

    Jimin Chen;Jiake Xu;Allan Wang;Minghao Zheng

  • Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kappaB in giant cell tumor of bone: possible involvement in tumor cell-induced osteoclast-like cell formation.

    Lin Huang;JiaKe Xu;David J. Wood;Ming H. Zheng

  • Expression of RANKL and OPG mRNA in periodontal disease: possible involvement in bone destruction.

    D. Liu;Jiake Xu;L. Figliomeni;L. Huang

  • Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy.

    Chao Liang;Baosheng Guo;Heng Wu;Ningsheng Shao

  • The chondrocyte: biology and clinical application.

    Zhen Lin;Craig Willers;Jiake Xu;Ming-Hao Zheng

  • Correction: Corrigendum: NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase

    Vincent Kuek;Zhifan Yang;Shek Man Chim;Sipin Zhu

  • NF-kappaB modulators in osteolytic bone diseases.

    Jiake Xu;Hua Fei Wu;Estabelle S.M. Ang;Kirk Yip

  • Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version).

    Dewei Zhao;Feng Zhang;Benjie Wang;Baoyi Liu

  • Angiogenic factors in bone local environment

    Shek Man Chim;Jennifer Tickner;Siu To Chow;Vincent Kuek

  • Gene Expression Profiles of Human Chondrocytes during Passaged Monolayer Cultivation

    Zhen Lin;Jonathan B. Fitzgerald;Jiake Xu;Craig Willers

  • Interaction between osteoblast and osteoclast: impact in bone disease.

    Tony Phan;Jiake Xu;Ming Zheng

  • Matrix-induced autologous chondrocyte implantation (MACI): biological and histological assessment.

    Ming-Hao Zheng;Craig Willers;Lyn Kirilak;Piers Yates

  • Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized-Induced Bone Loss by Suppressing Reactive Oxygen Species.

    Kai Chen;Pengcheng Qiu;Yu Yuan;Yu Yuan;Lin Zheng

  • 12-O-tetradecanoylphorbol-13-acetate (TPA) Inhibits Osteoclastogenesis by Suppressing RANKL-Induced NF-κB Activation

    Cathy Wang;James H. Steer;David A. Joyce;Kirk H. M. Yip

Frequent Co-Authors

Renxiang Tan
Renxiang Tan Nanjing University
Ge Zhang
Ge Zhang Hong Kong Baptist University
Vicki Rosen
Vicki Rosen Harvard University
Paul A. Lyons
Paul A. Lyons University of Cambridge
Kerong Dai
Kerong Dai Shanghai Jiao Tong University
Scott G. Wilson
Scott G. Wilson University of Western Australia
Matthew T. Gillespie
Matthew T. Gillespie Monash University
Reinhard Jahn
Reinhard Jahn Max Planck Society
Anthony A. Scalzo
Anthony A. Scalzo University of Western Australia
Robert Layfield
Robert Layfield University of Nottingham

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