World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
127
Citations
49256
World Ranking
2860
National Ranking
291

Research.com Recognitions

  • 2005 - Fellow of the Royal Society of Edinburgh

Overview

Stuart H. Ralston is affiliated with the University of Edinburgh in the United Kingdom. Their research spans multiple disciplines, primarily focusing on medicine and biochemistry, genetics, and molecular biology. These fields encompass a wide range of biomedical investigations, with a significant emphasis on musculoskeletal and connective tissue conditions.

The scientist's notable research areas include bone health and treatments, connective tissue disorders research, bone health and osteoporosis research, bone metabolism and diseases, bone and joint diseases, rheumatoid arthritis research and therapies, and medical imaging and pathology studies. Their work contributes to both clinical and molecular understandings of these topics.

Stuart H. Ralston has published extensively, with several papers that have garnered significant citations. Key recent publications include:

  • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations (2021, Cell)
  • Fracture Risk and Management of Discontinuation of Denosumab Therapy: A Systematic Review and Position Statement by ECTS (2020, The Journal of Clinical Endocrinology & Metabolism)
  • Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial (2020, The Lancet)
  • Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial (2022, The Lancet)
  • Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial (2021, Circulation)

Their collaborative work includes frequent co-authors such as Kathryn Berg, Barbara Hauser, Asim Azfer, Omar Albagha, and Jonathan H. Tobias. These collaborations suggest an interdisciplinary approach across genetics, clinical medicine, and molecular biology.

Stuart H. Ralston has contributed predominantly to journals including:

  • Calcified Tissue International
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Bone and Mineral Research
  • Lara D. Veeken
  • Bone Reports

Their publication record, exceeding 205 papers in medicine and 59 in biochemistry, genetics, and molecular biology, reflects a broad and sustained research effort. Subfields of focus incorporate oncology, molecular biology, rheumatology, orthopedics and sports medicine, and genetics.

In recognition of their contributions, Stuart H. Ralston was named a Fellow of the Royal Society of Edinburgh in 2005.

Best Publications

  • A randomized trial of vertebroplasty for osteoporotic spinal fractures

    David F. Kallmes;Bryan A. Comstock;Patrick J. Heagerty;Judith A. Turner

  • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

    Karol Estrada;Unnur Styrkarsdottir;Evangelos Evangelou;Yi-Hsiang Hsu

  • SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

    Veronique Vitart;Igor Rudan;Igor Rudan;Caroline Hayward;Nicola K Gray;Nicola K Gray

  • Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene.

    Struan F. A. Grant;David M. Reid;Glen Blake;Ruth Herd

  • Twenty bone mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

    Fernando Rivadeneira;Unnur Styrkarsdottir;Karol Estrada;Bjarni V. Halldorsson

  • Nitric oxide and bone.

    Robert Jurgen Van T Hof;S Ralston

  • Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis.

    A. E. Hughes;S. H. Ralston;J. Marken;C. Bell

  • A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis

    S Lekamwasam;J D Adachi;D Agnusdei;J Bilezikian

  • A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality

    Val Mann;Emma E. Hobson;Baohua Li;Tracy L. Stewart

  • Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study

    Philip C Haycock;Stephen Burgess;Aayah Nounu

  • Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

    Hou Feng Zheng;Vincenzo Forgetta;Yi Hsiang Hsu;Yi Hsiang Hsu;Karol Estrada

  • Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS.

    Elena Tsourdi;Bente Langdahl;Martine Cohen-Solal;Bérengere Aubry-Rozier

  • Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro

    Aymen I. Idris;Javier Rojas;Iain R. Greig;Rob J. van’t Hof

  • A UK Consensus Group on management of glucocorticoid‐induced osteoporosis: an update

    R. Eastell;D. M. Reid;J. Compston;C. Cooper

  • Genetic regulation of bone mass and susceptibility to osteoporosis

    Stuart H. Ralston;Benoit de Crombrugghe

  • Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

    Fraser P. Coxon;Miep H. Helfrich;Robert Van't Hof;Saïd Sebti

  • Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study

    E Zeggini;K Panoutsopoulou

  • Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors

    Aymen I Idris;Aymen I Idris;Robert J van 't Hof;Robert J van 't Hof;Iain R Greig;Susan A Ridge

  • Genetics of Osteoporosis

    Stuart H. Ralston;André G. Uitterlinden

  • Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes.

    John P. A. Ioannidis;Stuart H. Ralston;Simon T. Bennett;Maria Luisa Brandi

Frequent Co-Authors

William D. Fraser
William D. Fraser Université de Sherbrooke
André G. Uitterlinden
André G. Uitterlinden Erasmus University Rotterdam
John P. A. Ioannidis
John P. A. Ioannidis Stanford University
David M. Reid
David M. Reid University of Aberdeen
Kari Stefansson
Kari Stefansson deCODE Genetics (Iceland)
Fernando Rivadeneira
Fernando Rivadeneira Erasmus University Rotterdam
Unnur Thorsteinsdottir
Unnur Thorsteinsdottir deCODE Genetics (Iceland)
Douglas P. Kiel
Douglas P. Kiel Beth Israel Deaconess Medical Center
Tim D. Spector
Tim D. Spector King's College London
Emma L. Duncan
Emma L. Duncan King's College London

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