World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
22899
World Ranking
8481
National Ranking
656

Overview

Paul A. Lyons is affiliated with the University of Cambridge in the United Kingdom. Their work spans several related scientific fields, with a primary focus on Medicine, supported by substantial contributions to Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology.

The scientist's research covers multiple subfields including Infectious Diseases, Immunology, Genetics, Molecular Biology, and Neurology. These areas reflect the scope and interdisciplinary nature of their investigations.

The main research topics addressed by Paul A. Lyons include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Inflammatory Bowel Disease
  • Long-Term Effects of COVID-19
  • Immune Cell Function and Interaction
  • Microscopic Colitis
  • Immunodeficiency and Autoimmune Disorders

Lyons has published scientific papers in notable venues, highlighted by substantial publication counts in the following journals and repositories:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Nature
  • Cell Reports
  • Nature Immunology

Among recent papers, some of the most cited works include:

  • Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity, 2022, Nature
  • SARS-CoV-2 evolution during treatment of chronic infection, 2021, Nature
  • ANCA-associated vasculitis, 2020, Nature Reviews Disease Primers
  • Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2, 2021, Nature
  • Single-cell multi-omics analysis of the immune response in COVID-19, 2021, Nature Medicine

Frequent collaborative work with other researchers is a feature of Lyons's career. Notable frequent co-authors include:

  • Kenneth G. C. Smith
  • John R. Bradley
  • Federica Mescia
  • Laura Bergamaschi
  • Nathalie Kingston

The scientist is also an author of books, with publication in the area of clinical practice. A listed publication is:

  • Obstetrics in Family Medicine, published by Current Clinical Practice, 2025

Best Publications

  • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

    Y. Okazaki;M. Furuno;T. Kasukawa;J. Adachi

  • Genetically Distinct Subsets within ANCA-Associated Vasculitis

    Paul A Lyons;Tim F Rayner;Sapna Trivedi;Julia U Holle

  • SARS-CoV-2 evolution during treatment of chronic infection.

    Steven A. Kemp;Dami A. Collier;Dami A. Collier;Rawlings P. Datir;Isabella A. T. M. Ferreira

  • Functional annotation of a full-length mouse cDNA collection

    J. Kawai;A. Shinagawa;K. Shibata;M. Yoshino

  • Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.

    Dami A Collier;Dami A Collier;Isabella A T M Ferreira;Prasanti Kotagiri;Rawlings P Datir;Rawlings P Datir

  • T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

    Eoin F. McKinney;James C. Lee;David R. W. Jayne;Paul A. Lyons

  • Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.

    Dami A. Collier;Dami A. Collier;Anna De Marco;Isabella A. T. M. Ferreira;Bo Meng

  • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

    Jun Yamanouchi;Dan Rainbow;Pau Serra;Sarah Howlett

  • A CD8 + T cell transcription signature predicts prognosis in autoimmune disease

    Eoin F McKinney;Paul A Lyons;Edward J Carr;Jane L Hollis

  • Whole-genome sequencing of patients with rare diseases in a national health system

    Ernest Turro;William J Astle;Karyn Megy;Stefan Graf

  • A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

    Ricardo C. Ferreira;Hui Guo;Richard M R Coulson;Deborah J. Smyth

  • Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.

    Laura Bergamaschi;Federica Mescia;Lorinda Turner;Aimee L. Hanson

  • Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

    James C. Lee;Paul A. Lyons;Eoin F. McKinney;John M. Sowerby

  • Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

    Lisa C. Willcocks;Paul A. Lyons;Menna R. Clatworthy;James I. Robinson

  • Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

    James C Lee;Daniele Biasci;Rebecca Roberts;Richard B Gearry

  • Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway

    James C. Lee;Marion Espéli;Carl A. Anderson;Michelle A. Linterman

  • Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

    Martin M Fabani;Cei Abreu-Goodger;Donna Williams;Paul Anthony Lyons

  • Targeting a Complex Transcriptome: The Construction of the Mouse Full-Length cDNA Encyclopedia

    Piero Carninci;Kazunori Waki;Toshiyuki Shiraki;Hideaki Konno

  • Analysis of the B cell receptor repertoire in six immune-mediated diseases.

    Rachael Bashford-Rogers;Rachael Bashford-Rogers;Laura Bergamaschi;Eoin McKinney;DC Pombal

  • A thermostable, closed, SARS-CoV-2 spike protein trimer

    Xiaoli Xiong;Kun Qu;Katarzyna A. Ciazynska;Myra Hosmillo

Frequent Co-Authors

Kenneth G. C. Smith
Kenneth G. C. Smith Walter and Eliza Hall Institute of Medical Research
James Lee
James Lee The Francis Crick Institute
John A. Todd
John A. Todd University of Oxford
Laurence B. Peterson
Laurence B. Peterson Roche (Switzerland)
Gordon Dougan
Gordon Dougan University of Cambridge
Linda S. Wicker
Linda S. Wicker University of Oxford
David Jayne
David Jayne University of Cambridge
Miles Parkes
Miles Parkes University of Cambridge
Willem H. Ouwehand
Willem H. Ouwehand University of Cambridge
Stephen Baker
Stephen Baker Agency for Science, Technology and Research

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