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D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
40775
World Ranking
3984
National Ranking
298

Research.com Recognitions

  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

James Lee is affiliated with The Francis Crick Institute in the United Kingdom. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with particular attention to several subfields including Genetics, Immunology, Epidemiology, Surgery, and Molecular Biology.

Lee's work spans topics such as Inflammatory Bowel Disease, Microscopic Colitis, Cardiac Valve Diseases and Treatments, Immune Cell Function and Interaction, T-cell and B-cell Immunology, Immunodeficiency and Autoimmune Disorders, and Eosinophilic Esophagitis.

They have published frequently in journals including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Crohn's and Colitis
  • Gastroenterology
  • Journal of Cardiovascular Computed Tomography
  • The American Journal of Surgery

Frequent collaborators in Lee's research include Kenneth G. C. Smith, Paul Lyons, Eoin McKinney, Miles Parkes, and Nurulamin M Noor.

Recent notable publications include:

  • A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial, 2024, The Lancet. Gastroenterology & Hepatology
  • New Approaches to SCLC Therapy: From the Laboratory to the Clinic, 2020, Journal of Thoracic Oncology
  • A disease-associated gene desert directs macrophage inflammation through ETS2, 2024, Nature
  • Vitamin D regulates microbiome-dependent cancer immunity, 2024, Science
  • FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle, 2020, Cell

James Lee was awarded the title of Fellow of the American Association for the Advancement of Science (AAAS) in 2001.

Best Publications

  • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

    Luke Jostins;Stephan Ripke;Rinse K Weersma;Richard H Duerr

  • A reference panel of 64,976 haplotypes for genotype imputation

    Shane McCarthy;Sayantan Das;Warren Kretzschmar;Olivier Delaneau

  • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

    Andre Franke;Dermot P B McGovern;Jeffrey C. Barrett;Kai Wang

  • Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

    J Z Liu;S van Sommeren;H Huang;S C Ng

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Carl A. Anderson;Gabrielle Boucher;Charlie W. Lees;Andre Franke

  • The stabilization of proteins by sucrose.

    James Lee;S. N. Timasheff

  • Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

    Katrina M de Lange;Loukas Moutsianas;James C Lee;Christopher A Lamb

  • Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Phil H. Lee;Verneri Anttila;Hyejung Won;Yen-Chen A. Feng

  • Mapping of a susceptibility locus for Crohn's disease on chromosome 16

    J P Hugot;P Laurent-Puig;C Gower-Rousseau;J M Olson

  • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.

    Marcel Batten;J i Li;Sothy Yi;Noelyn M Kljavin

  • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

    Nick Craddock;Matthew E. Hurles;Niall Cardin;Richard D. Pearson

  • Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

    Isabelle Cleynen;Isabelle Cleynen;Gabrielle Boucher;Luke Jostins;Luke Jostins;Luke Jostins;L Philip Schumm

  • T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

    Eoin F. McKinney;James C. Lee;David R. W. Jayne;Paul A. Lyons

  • Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

    Jeffrey C Barrett;James C Lee;Charles W Lees;Natalie J Prescott

  • [36] Preparation of tubulin from brain

    Robley C. Williams;James C. Lee

  • The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment

    Hilary F. Clark;Austin L. Gurney;Evangeline Abaya;Kevin Baker

  • Partial specific volumes and interactions with solvent components of proteins in guanidine hydrochloride.

    James C. Lee;Serge N. Timasheff

  • The cellular composition of the human immune system is shaped by age and cohabitation

    Edward J Carr;James Dooley;Josselyn E Garcia-Perez;Vasiliki Lagou

  • Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

    James C. Lee;Paul A. Lyons;Eoin F. McKinney;John M. Sowerby

  • RIP3, a novel apoptosis-inducing kinase.

    Xiaoqing Sun;James Lee;Tony Navas;Daryl T. Baldwin

Frequent Co-Authors

Miles Parkes
Miles Parkes University of Cambridge
Kenneth G. C. Smith
Kenneth G. C. Smith Walter and Eliza Hall Institute of Medical Research
Paul A. Lyons
Paul A. Lyons University of Cambridge
Peter Fischer
Peter Fischer Lawrence Berkeley National Laboratory
Tariq Ahmad
Tariq Ahmad Yale University
Carl A. Anderson
Carl A. Anderson Wellcome Sanger Institute
Jack Satsangi
Jack Satsangi University of Oxford
Christopher G. Mathew
Christopher G. Mathew King's College London
John L. Rinn
John L. Rinn University of Colorado Boulder
Eric E. Fullerton
Eric E. Fullerton University of California, San Diego

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