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D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
38643
World Ranking
17379
National Ranking
1364

Overview

Robert Layfield is affiliated with the University of Nottingham in the United Kingdom. Their research spans across the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, with specific subfields including Molecular Biology, Genetics, Organic Chemistry, Neurology, and Oncology.

Their recent publication record highlights contributions to chemical modifications of peptides and proteins, neurobiology, and cellular signaling pathways. Notable papers include:

  • Site-Selective Modification of Peptides and Proteins via Interception of Free-Radical-Mediated Dechalcogenation, 2020, Angewandte Chemie International Edition
  • Site-Selective Installation of Nϵ-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C-C Bond Formation, 2021, Angewandte Chemie International Edition
  • p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death, 2021, Scientific Reports
  • ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation, 2020, Molecular and Cellular Neuroscience
  • Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C−C Bond Formation, 2022, Chemistry - A European Journal

Their work has been published repeatedly in venues such as Neuro-Oncology, IUPHAR/BPS Guide to Pharmacology CITE, Angewandte Chemie International Edition, Scientific Reports, and Angewandte Chemie.

Frequent collaborators within their research network include:

  • Farhana Haque
  • Ruman Rahman
  • Elena Faccenda
  • Anya Snary
  • Jed Long

Layfield's research topics cover a range of biochemical and pharmacological areas, including:

  • Ubiquitin and proteasome pathways
  • Protein Degradation and Inhibitors
  • Click Chemistry and Applications
  • Glioma Diagnosis and Treatment
  • Chemical Synthesis and Analysis
  • Peptidase Inhibition and Analysis
  • Autophagy in Disease and Therapy

In addition to articles, Layfield has contributed to book publications, including titles published by IntechOpen. One such work is Modifications in Biomacromolecules from 2022.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle.

    Paul L. Greenhaff;Leonidas Karagounis;Nicholas Peirce;Elizabeth J Simpson

  • α-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

    George K Tofaris;Robert Layfield;Maria Grazia Spillantini

  • Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies

    Lynn Bedford;David Hay;Anny Devoy;Simon Paine

  • Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

    Y A Lam;C M Pickart;A Alban;M Landon

  • Proteasomal degradation of tau protein.

    Della C. David;Robert Layfield;Louise Serpell;Yolanda Narain

  • Oligodendrocytes Promote Neuronal Survival and Axonal Length by Distinct Intracellular Mechanisms: A Novel Role for Oligodendrocyte-Derived Glial Cell Line-Derived Neurotrophic Factor

    Alastair Wilkins;Henry Majed;Robert Layfield;Alastair Compston

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

    Ian M. Copple;Adam Lister;Akua D. Obeng;Neil R. Kitteringham

  • Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins.

    Layfield R;Fergusson J;Aitken A;Lowe J

  • Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch.

    Jed Long;Thomas R.A. Gallagher;James R. Cavey;Paul W. Sheppard

  • Pathogenesis of Paget Disease of Bone

    Stuart H. Ralston;Rob Layfield

  • Boning up on autophagy: the role of autophagy in skeletal biology.

    Irving M Shapiro;Robert Layfield;Martin Lotz;Carmine Settembre

  • Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences.

    Lynne J. Hocking;Gavin J. A. Lucas;Anna Daroszewska;Tim Cundy

  • SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD

    Sarah L. Rea;Veronika Majcher;Mark S. Searle;Rob Layfield

  • Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.

    Robert Layfield;James R Cavey;James Lowe

  • Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms

    Alastair Wilkins;Henry Majed;Robert Layfield;Alastair Compston

Frequent Co-Authors

Mark S. Searle
Mark S. Searle University of Nottingham
Stuart H. Ralston
Stuart H. Ralston University of Edinburgh
Neil J. Oldham
Neil J. Oldham University of Nottingham
Sergio Lavandero
Sergio Lavandero University of Chile
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Evelina Gatti
Evelina Gatti Aix-Marseille University
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Felix Randow
Felix Randow MRC Laboratory of Molecular Biology
Philippe Pierre
Philippe Pierre Aix-Marseille University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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