Mark S. Searle

Overview

Best Publications

• The cost of conformational order: entropy changes in molecular associations

  Mark S. Searle;Dudley H. Williams

  460
  Citations

• Empirical Correlations between Thermodynamic Properties and Intermolecular Forces

  Martin S. Westwell;Mark S. Searle;David J. Wales;Dudley H. Williams

  303
  Citations

• Origin of β-Hairpin Stability in Solution: Structural and Thermodynamic Analysis of the Folding of a Model Peptide Supports Hydrophobic Stabilization in Water

  Allister J. Maynard;Gary J. Sharman;Mark S. Searle

  288
  Citations

• Glycopeptide antibiotic activity and the possible role of dimerization : A model for biological signaling

  Joel P. Mackay;Ute Gerhard;Daniel A. Beauregard;Dudley H. Williams

  248
  Citations

• A short linear peptide derived from the N-terminal sequence of ubiquitin folds into a water-stable non-native beta-hairpin.

  Mark S. Searle;Dudley H. Williams;Leonard C. Packman

  235
  Citations

• Drug Recognition and Stabilisation of the Parallel-stranded DNA Quadruplex d(TTAGGGT)4 Containing the Human Telomeric Repeat

  Evripidis Gavathiotis;Robert A. Heald;Malcolm F.G. Stevens;Mark S. Searle

  233
  Citations

• Partitioning of free energy contributions in the estimation of binding constants : Residual motions and consequences for amide-amide hydrogen bond strengths

  Mark S. Searle;Dudley H. Williams;Ute Gerhard

  233
  Citations

• Toward an estimation of binding constants in aqueous solution: studies of associations of vancomycin group antibiotics.

  Dudley H. Williams;Mark S. Searle;Joel P. Mackay;Ute Gerhard

  228
  Citations

• On the stability of nucleic acid structures in solution: enthalpy - entropy compensations, internal rotations and reversibility

  Mark S. Searle;Dudley H. Williams

  221
  Citations

• Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch.

  Jed Long;Thomas R.A. Gallagher;James R. Cavey;Paul W. Sheppard

  218
  Citations

• Dissecting the stability of a beta-hairpin peptide that folds in water: NMR and molecular dynamics analysis of the beta-turn and beta-strand contributions to folding.

  Samuel R Griffiths-Jones;Allister J Maynard;Mark S Searle

  210
  Citations

• Cooperativity in Drug−DNA Recognition: A Molecular Dynamics Study

  Sarah A. Harris;Evripidis Gavathiotis;Mark S. Searle;Modesto Orozco

  196
  Citations

• Application of a generalised enthalpy–entropy relationship to binding co-operativity and weak associations in solution

  Mark S. Searle;Martin S. Westwell;Dudley H. Williams

  192
  Citations

• Cooperative Interaction between the Three Strands of a Designed Antiparallel β-Sheet

  Gary J. Sharman and;Mark S. Searle

  168
  Citations

• Structure of the Ubiquitin-associated Domain of p62 (SQSTM1) and Implications for Mutations That Cause Paget's Disease of Bone

  Barbara Ciani;Robert Layfield;James R. Cavey;Paul W. Sheppard

  162
  Citations

• Structure, folding, and energetics of cooperative interactions between the beta-strands of a de novo sesigned three-stranded antiparallel beta-sheet peptide

  Samuel R. Griffiths-Jones and;Mark S. Searle

  159
  Citations

• Stabilization of β-Hairpin Peptides by Salt Bridges: Role of Preorganization in the Energetic Contribution of Weak Interactions

  Barbara Ciani;Muriel Jourdan;Mark S. Searle

  144
  Citations

• Dimerisation of the UBA Domain of p62 Inhibits Ubiquitin Binding and Regulates NF-κB Signalling

  Jed Long;Thomas P. Garner;Maya J. Pandya;C. Jeremy Craven

  139
  Citations

• Design of β-sheet systems for understanding the thermodynamics and kinetics of protein folding

  Mark S Searle;Barbara Ciani

  131
  Citations

• NMR studies of the interaction of the antibiotic nogalamycin with the hexadeoxyribonucleotide duplex d(5'-GCATGC)2.

  Mark S. Searle;Jon G. Hall;William A. Denny;Laurence P. G. Wakelin

  121
  Citations