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D-Index & Metrics

Chemistry

D-Index
53
Citations
11604
World Ranking
12974
National Ranking
732

Overview

Charles A. Laughton is affiliated with the University of Nottingham in the United Kingdom. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a focus on several interconnected subfields including Molecular Biology, Biomedical Engineering, Information Systems and Management, Immunology, and Information Systems.

The scientist's work covers a range of specialized topics, highlighting areas such as DNA and Nucleic Acid Chemistry, RNA and protein synthesis mechanisms, Scientific Computing and Data Management, Protein Structure and Dynamics, Nanopore and Nanochannel Transport Studies, Advanced biosensing and bioanalysis techniques, and Research Data Management Practices.

Among the recent publications attributed to this scientist are:

  • Sequence-dependent structural properties of B-DNA: what have we learned in 40 years? (2021) in Biophysical Reviews
  • GLIMPS: A Machine Learning Approach to Resolution Transformation for Multiscale Modeling (2021) in Journal of Chemical Theory and Computation
  • The need to implement FAIR principles in biomolecular simulations (2025) in Nature Methods
  • Optimizing Excipient Properties to Prevent Aggregation in Biopharmaceutical Formulations (2023) in Journal of Chemical Information and Modeling
  • Nanoformulation-by-design: an experimental and molecular dynamics study for polymer coated drug nanoparticles (2020) in RSC Advances

Laughton frequently collaborates with several researchers in their field. The most common co-authors include Modesto Orozco, Sarah A. Harris, Adam Hospital, Federica Battistini, and Paolo Carloni.

The venues where this scientist commonly publishes are notable for their focus on molecular and biophysical research. Frequent publication venues include Biophysical Reviews, Nucleic Acids Research, arXiv (Cornell University), bioRxiv (Cold Spring Harbor Laboratory), and Nature Methods.

Best Publications

  • Refinement of the AMBER Force Field for Nucleic Acids: Improving the Description of α/γ Conformers

    Alberto Pérez;Iván Marchán;Daniel Svozil;Daniel Svozil;Jiri Sponer;Jiri Sponer

  • Parmbsc1: a refined force field for DNA simulations

    Ivan Ivani;Pablo D Dans;Agnes Noy;Alberto Pérez

  • Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

    Yeh-Chih Kao;Changbao Zhou;Mark Sherman;Charles A. Laughton

  • A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step conformations and fluctuations in B-DNA

    Richard Lavery;Krystyna Zakrzewska;David Beveridge;Thomas C. Bishop

  • μABC: a systematic microsecond molecular dynamics study of tetranucleotide sequence effects in B-DNA

    Marco Pasi;John H. Maddocks;David Beveridge;Thomas C. Bishop

  • Van der Waals interactions dominate ligand-protein association in a protein binding site occluded from solvent water.

    Elizabeth Barratt;Richard J. Bingham;Daniel J. Warner;Charles A. Laughton

  • Molecular Dynamics Simulations of the d(T·A·T) Triple Helix

    George C. Shields;Charles A. Laughton;Modesto Orozco

  • Cooperativity in Drug−DNA Recognition: A Molecular Dynamics Study

    Sarah A. Harris;Evripidis Gavathiotis;Mark S. Searle;Modesto Orozco

  • Biomolecular simulations: From dynamics and mechanisms to computational assays of biological activity

    David J. Huggins;David J. Huggins;Philip C. Biggin;Marc A. Dämgen;Jonathan W. Essex

  • Antitumor Polycyclic Acridines. 8.1 Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium Salts

    Robert A. Heald;Chetna Modi;Jenny C. Cookson;Ian Hutchinson

  • Design, synthesis, and biophysical and biological evaluation of a series of Pyrrolobenzodiazepine - Poly(N-methylpyrrole) conjugates

    Geoff Wells;Christopher R H Martin;Philip W Howard;Zara A Sands

  • Essential Dynamics: A Tool for Efficient Trajectory Compression and Management

    Meyer T;Ferrer-Costa C;Pérez A;Rueda M

  • A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity.

    C.A Laughton;F Tanious;C.M Nunn;D.W Boykin

  • Binding Characteristics of Seven Inhibitors of Human Aromatase: A Site-directed Mutagenesis Study

    Yeh-Chih Kao;Linh L. Cam;Charles A. Laughton;Dujin Zhou

  • Acquired Resistance to Temozolomide in Glioma Cell Lines: Molecular Mechanisms and Potential Translational Applications

    Jihong Zhang;Malcolm F.G. Stevens;Charles A. Laughton;Srinivasan Madhusudan

  • Molecular Dynamics Simulation of a PNA·DNA·PNA Triple Helix in Aqueous Solution

    George C. Shields;Charles A. Laughton;Modesto Orozco

  • Atomistic simulations reveal bubbles, kinks and wrinkles in supercoiled DNA

    J. S. Mitchell;C. A. Laughton;Sarah A. Harris

  • Molecular Dynamics Studies of DNA A-Tract Structure and Flexibility

    Edward C. Sherer;Sarah A. Harris;Robert Soliva;Modesto Orozco

  • A molecular model for the enzyme cytochrome P45017α, a major target for the chemotherapy of prostatic cancer

    C.A. Laughton;S. Neidle;M.J.J.M. Zvelebil;M.J.E. Sternberg

  • Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: activity in human tumor cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents.

    Jennifer C. Cookson;Fangping Dai;Victoria Smith;Robert A. Heald

  • Elucidation of thioredoxin as a molecular target for antitumor quinols.

    Tracey D. Bradshaw;Charles S. Matthews;Jennifer Cookson;Eng-Hui Chew

  • Large-scale molecular dynamics simulation of DNA: implementation and validation of the AMBER98 force field in LAMMPS.

    Christina Grindon;Sarah Harris;T. O. M. Evans;Keir Novik

Frequent Co-Authors

Modesto Orozco
Modesto Orozco University of Barcelona
Stephen Neidle
Stephen Neidle University College London
Malcolm F. G. Stevens
Malcolm F. G. Stevens University of Nottingham
Peter M. Fischer
Peter M. Fischer University of Nottingham
Alberto Perez
Alberto Perez University of Florida
David A. Barrett
David A. Barrett University of Nottingham
Shantenu Jha
Shantenu Jha Rutgers, The State University of New Jersey
F. Javier Luque
F. Javier Luque University of Barcelona
Shiuan Chen
Shiuan Chen City Of Hope National Medical Center
Cameron Alexander
Cameron Alexander University of Nottingham

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