D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 68 Citations 17,369 101 World Ranking 3381 National Ranking 1743

Research.com Recognitions

Awards & Achievements

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Biochemistry

His primary scientific interests are in Collagenase, Matrix metalloproteinase, Molecular biology, Biochemistry and Interstitial collagenase. His Collagenase study integrates concerns from other disciplines, such as Connective tissue and Basement membrane. His biological study spans a wide range of topics, including Immunohistochemistry, Pathology and In situ hybridization.

His Molecular biology research is multidisciplinary, relying on both Complementary DNA, Nucleic acid sequence, Macrophage elastase and Collagen, type I, alpha 1. His Biochemistry study which covers Elastin that intersects with Elastase and Pancreatic elastase. The study incorporates disciplines such as Extracellular matrix, Cell biology and Macrophage in addition to Interstitial collagenase.

His most cited work include:

  • The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix (521 citations)
  • Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist. (488 citations)
  • Human 92- and 72-kilodalton type IV collagenases are elastases. (483 citations)

What are the main themes of his work throughout his whole career to date?

Howard G. Welgus spends much of his time researching Collagenase, Biochemistry, Molecular biology, Matrix metalloproteinase and Interstitial collagenase. His research integrates issues of Type I collagen, Endocrinology, Internal medicine, Fibroblast and Extracellular matrix in his study of Collagenase. His work in Biochemistry tackles topics such as Elastin which are related to areas like Elastase.

His research in Molecular biology intersects with topics in U937 cell, Matrilysin, Macrophage elastase, Peptide sequence and Phorbol. His Matrix metalloproteinase research is multidisciplinary, incorporating perspectives in Pathology, Macrophage and Cell biology. Howard G. Welgus combines subjects such as Osteoclast, Type IV collagen, Cellular differentiation and Proteolysis with his study of Interstitial collagenase.

He most often published in these fields:

  • Collagenase (59.69%)
  • Biochemistry (43.41%)
  • Molecular biology (38.76%)

What were the highlights of his more recent work (between 1997-2016)?

  • Matrix metalloproteinase (35.66%)
  • Cell biology (23.26%)
  • Molecular biology (38.76%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Matrix metalloproteinase, Cell biology, Molecular biology, Collagenase and Biochemistry. His study in Matrix metalloproteinase is interdisciplinary in nature, drawing from both Extracellular matrix and High-density lipoprotein. His Cell biology research incorporates elements of Type I collagen, Autocrine signalling and Epidermal growth factor receptor.

His Molecular biology research is multidisciplinary, relying on both Vector, Recombinant DNA, Collagenase Inhibitor, Macrophage elastase and Fibroblast. His Collagenase study combines topics in areas such as Lipopolysaccharide, Secretion and Microbiology. His work in the fields of Biochemistry, such as Peptide, Substrate and Glycosylation, overlaps with other areas such as N-linked glycosylation.

Between 1997 and 2016, his most popular works were:

  • Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization (399 citations)
  • Matrilysin expression and function in airway epithelium. (256 citations)
  • Role of Matrix Metalloproteinases and Their Inhibition in Cutaneous Wound Healing and Allergic Contact Hypersensitivity (177 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

The scientist’s investigation covers issues in Matrix metalloproteinase, Molecular biology, Immunology, Gelatinase and Matrilysin. He combines subjects such as T cell, CD8, Macrophage elastase, Monocyte and Fibroblast with his study of Molecular biology. The concepts of his Immunology study are interwoven with issues in Stromelysin 1 and Lymph.

As a part of the same scientific study, he usually deals with the Gelatinase, concentrating on Alveolar Epithelium and frequently concerns with Wound healing. To a larger extent, Howard G. Welgus studies Biochemistry with the aim of understanding Matrilysin. His studies deal with areas such as Endothelial stem cell, Collagenase and Keratinocyte as well as Cancer research.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix

Brian K. Pilcher;Jo Ann Dumin;Barry D. Sudbeck;Stephen M. Krane.
Journal of Cell Biology (1997)

801 Citations

Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist.

William P. Arend;Howard G. Welgus;Robert C. Thompson;Stephen P. Eisenberg.
Journal of Clinical Investigation (1990)

754 Citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

R. M. Senior;G. L. Griffin;C. J. Fliszar;S. D. Shapiro.
Journal of Biological Chemistry (1991)

746 Citations

Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization

Lynn A. Cornelius;Leslie C. Nehring;Elizabeth Harding;Mark Bolanowski.
Journal of Immunology (1998)

617 Citations

Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.

H G Welgus;E J Campbell;J D Cury;A Z Eisen.
Journal of Clinical Investigation (1990)

610 Citations

IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes.

S Lacraz;L P Nicod;R Chicheportiche;H G Welgus.
Journal of Clinical Investigation (1995)

547 Citations

Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages.

R. W. Thompson;D. R. Holmes;R. A. Mertens;Shixiong Liao.
Journal of Clinical Investigation (1995)

520 Citations

The collagen substrate specificity of human skin fibroblast collagenase.

H G Welgus;J J Jeffrey;A Z Eisen.
Journal of Biological Chemistry (1981)

512 Citations

Interstitial Collagenase (MMP-1) Expression in Human Carotid Atherosclerosis

Seppo T. Nikkari;Kevin D. O’Brien;Marina Ferguson;Thomas Hatsukami.
Circulation (1995)

508 Citations

Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.

Igor Halpert;Ulrike I. Sires;Jill D. Roby;Susan Potter-Perigo.
Proceedings of the National Academy of Sciences of the United States of America (1996)

497 Citations

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