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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
112
Citations
59515
World Ranking
880
National Ranking
48

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Hideaki Nagase is affiliated with the University of Oxford in the United Kingdom and has an extensive publication record in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans various subfields, including Cancer Research, Molecular Biology, Cell Biology, Rheumatology, and Immunology and Allergy.

The scientist's research addresses multiple topics such as Protease and Inhibitor Mechanisms, Calpain Protease Function and Regulation, Osteoarthritis Treatment and Mechanisms, Cell Adhesion Molecules Research, Ion Channel Regulation and Function, Pain Mechanisms and Treatments, and Blood Coagulation and Thrombosis Mechanisms.

Notable recent papers include:

  • TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1 (2020, Scientific Reports)
  • A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage (2022, Matrix Biology)
  • Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage (2020, Osteoarthritis and Cartilage Open)
  • ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α2δ Subunits, and Enables Calcium Current Enhancement (2022, Function)
  • Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets (2022, bioRxiv [Cold Spring Harbor Laboratory])

Frequent collaborators in their research include Simone Bonelli, Linda Troeberg, Simone Dario Scilabra, Kazuhiro Yamamoto, and Abdulrahman M E Gremida. These collaborations are reflected in multiple joint publications.

Common venues for publishing Hideaki Nagase's research are bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, Matrix Biology, Osteoarthritis and Cartilage Open, and Function, showing a consistent presence in journals covering molecular biology and medical research.

Best Publications

  • Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.

    Robert Visse;Hideaki Nagase

  • Structure and function of matrix metalloproteinases and TIMPs

    Hideaki Nagase;Robert Visse;Gillian Murphy

  • Tissue inhibitors of metalloproteinases: evolution, structure and function.

    Keith Brew;Deendayal Dinakarpandian;Hideaki Nagase;Hideaki Nagase

  • Activation mechanisms of matrix metalloproteinases.

    Nagase H

  • The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

    Keith Brew;Hideaki Nagase

  • Progress in matrix metalloproteinase research.

    Gillian Murphy;Hideaki Nagase

  • Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.

    M. D. Tortorella;T. C. Burn;M. A. Pratta;I. Abbaszade

  • Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion

    Noemi Ramos-DeSimone;Elizabeth Hahn-Dantona;John Sipley;Hideaki Nagase

  • Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.

    Franz-Xaver Gomis-Rüth;Klaus Maskos;Michael Betz;Andreas Bergner

  • Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

    Y Ogata;J.J. Enghild;H Nagase

  • Proteases involved in cartilage matrix degradation in osteoarthritis

    Linda Troeberg;Hideaki Nagase

  • TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)

    Masahide Kashiwagi;Masahide Kashiwagi;Micky Tortorella;Hideaki Nagase;Keith Brew

  • Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin).

    Ko Suzuki;Jan J. Enghild;Tatsuhisa Morodomi;Guy Salvesen

  • Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition. Implications for reversibility of liver fibrosis

    Frank R. Murphy;Razao Issa;Xiaoying Zhou;Shabna Ratnarajah

  • Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.

    Ilgar Abbaszade;Rui-Qin Liu;Fude Yang;Stuart A. Rosenfeld

  • Aggrecanases and cartilage matrix degradation.

    Hideaki Nagase;Masahide Kashiwagi

  • Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

    Linda Chung;Linda Chung;Deendayal Dinakarpandian;Naoto Yoshida;Janelle L Lauer-Fields;Janelle L Lauer-Fields

  • Degradation of interleukin 1beta by matrix metalloproteinases.

    Akira Ito;Akihira Mukaiyama;Yoshifumi Itoh;Hideaki Nagase

  • Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria : Association of MMP induction with bone resorption

    Kenichiro Kusano;Chisato Miyaura;Masaki Inada;Tatsuya Tamura

  • Matrix metalloproteinases and TIMPs

    J. F. Woessner;Hideaki Nagase

Frequent Co-Authors

Yoshifumi Itoh
Yoshifumi Itoh University of Oxford
Gillian Murphy
Gillian Murphy University of Cambridge
Jan J. Enghild
Jan J. Enghild Aarhus University
Keith Brew
Keith Brew Florida Atlantic University
Gregg B. Fields
Gregg B. Fields Florida Atlantic University
Jeremy Saklatvala
Jeremy Saklatvala University of Oxford
Motoharu Seiki
Motoharu Seiki University of Tokyo
Guy S. Salvesen
Guy S. Salvesen Sanford Burnham Prebys Medical Discovery Institute
George Bou-Gharios
George Bou-Gharios University of Liverpool
Klaus Maskos
Klaus Maskos Proteros biostructures GmbH

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