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Biology and Biochemistry

D-Index
57
Citations
11153
World Ranking
13886
National Ranking
1089

Overview

George Bou-Gharios is affiliated with the University of Liverpool in the United Kingdom. Their research spans biochemistry, genetics, molecular biology, and medicine, with a strong focus on subfields including molecular biology, rheumatology, clinical biochemistry, genetics, and biochemistry.

The scientist's recent publications cover topics related to osteoarthritis, connective tissue disorders, metabolism, and protease mechanisms. Some notable recent papers include:

  • SIRT1 directly activates autophagy in human chondrocytes, 2020, Cell Death Discovery
  • Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis, 2020, Calcified Tissue International
  • Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis, 2020, Arthritis Research & Therapy
  • Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis, 2020, Scientific Reports
  • Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin, 2023, Journal of Investigative Dermatology

Frequent coauthors collaborating with George Bou-Gharios include:

  • L. Ranganath
  • Brendan P. Norman
  • James A. Gallagher
  • Milad Khedr
  • Andrew Davison

In terms of publication venues, the scientist has contributed repeatedly to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Osteoarthritis and Cartilage
  • SSRN Electronic Journal
  • Metabolites
  • JIMD Reports

The main topics of George Bou-Gharios's research encompass:

  • Metabolism and Genetic Disorders
  • Osteoarthritis Treatment and Mechanisms
  • Amino Acid Enzymes and Metabolism
  • Connective tissue disorders research
  • Diet and metabolism studies
  • Protease and Inhibitor Mechanisms
  • Mitochondrial Function and Pathology

Best Publications

  • The Bone Marrow Functionally Contributes to Liver Fibrosis

    Francesco P Russo;Malcolm R Alison;Brian W Bigger;Eunice Amofah

  • Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse.

    Qi Long Lu;Christopher J Mann;Fang Lou;George Bou-Gharios

  • Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles

    Qi Long Lu;Adam Rabinowitz;Yun Chao Chen;Toshifumi Yokota

  • Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

    Xu Shi-Wen;Yunliang Chen;Christopher P. Denton;Mark Eastwood

  • Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.

    Xu Shi-wen;Christopher P Denton;Michael R Dashwood;Alan M Holmes

  • Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

    Markella Ponticos;Alan M. Holmes;Xu Shi-Wen;Patricia Leoni

  • Non-viral gene delivery in skeletal muscle: a protein factory.

    Ql L. Lu;George Bou-Gharios;Ta A. Partridge

  • Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

    Sonali Sonnylal;Xu Shi-Wen;Patricia Leoni;Katherine Naff

  • Platelet-derived growth factor-β receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing

    Vineeth S. Rajkumar;Xu Shiwen;Maria Bostrom;Patricia Leoni

  • Bone marrow‐derived myofibroblasts contribute functionally to scar formation after myocardial infarction

    M. J. Van Amerongen;G. Bou-Gharios;Eliane Popa;J. Van Ark

  • Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.

    Xu Shi-wen;Sarah L. Howat;Elisabetta A. Renzoni;Alan Holmes

  • Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction

    Catherine Alexakis;Terence Partridge;George Bou-Gharios

  • Endothelin Is a Downstream Mediator of Profibrotic Responses to Transforming Growth Factor β in Human Lung Fibroblasts

    Xu Shi-wen;Laura Kennedy;Elisabetta A. Renzoni;George Bou-Gharios

  • Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.

    Pascale V. Guillot;Oyebode Abass;J. H. Duncan Bassett;Sandra J. Shefelbine

  • CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-β1 in Embryonic Fibroblasts

    Xu Shi-wen;Lee Anne Stanton;Laura Kennedy;Daphne Pala

  • Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model.

    Dolores Vernet;Monica G Ferrini;Eliane G Valente;Thomas R Magee;Thomas R Magee

  • Matrix Contraction by Dermal Fibroblasts Requires Transforming Growth Factor-β/Activin-Linked Kinase 5, Heparan Sulfate-Containing Proteoglycans, and MEK/ERK: Insights into Pathological Scarring in Chronic Fibrotic Disease

    Yunliang Chen;Xu Shi-wen;Jonathan van Beek;Laura Kennedy

  • T-cell-dependent fibrosis in the mdx dystrophic mouse.

    Jamie Morrison;Qi Long Lu;Christian Pastoret;Terence Partridge

  • Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts

    Elisabetta A Renzoni;David J Abraham;Sarah Howat;Xu Shi-Wen

  • A potent far-upstream enhancer in the mouse pro alpha 2(I) collagen gene regulates expression of reporter genes in transgenic mice.

    G Bou-Gharios;L A Garrett;J Rossert;K Niederreither

Frequent Co-Authors

David Abraham
David Abraham University College London
Christopher P. Denton
Christopher P. Denton University College London
Carol M. Black
Carol M. Black University College London
Nicholas M. Fisk
Nicholas M. Fisk University of Queensland
Andrew A. Pitsillides
Andrew A. Pitsillides Royal Veterinary College
Terence A. Partridge
Terence A. Partridge Children’s National Health System
Andrew Leask
Andrew Leask University of Saskatchewan
Hideaki Nagase
Hideaki Nagase University of Oxford
Jeremy D. Pearson
Jeremy D. Pearson King's College London
Peter D. Clegg
Peter D. Clegg University of Liverpool

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