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Medicine

D-Index
98
Citations
34852
World Ranking
8929
National Ranking
867

Overview

David Abraham is affiliated with University College London in the United Kingdom and has contributed extensively to the field of medicine, with a primary focus on systemic sclerosis and related diseases. Their research spans various subfields including pathology and forensic medicine, molecular biology, epidemiology, pulmonary and respiratory medicine, and surgery.

They have published notably on topics related to systemic sclerosis, autoimmune bullous skin diseases, connective tissue growth factor research, inflammatory myopathies and dermatomyositis, pulmonary hypertension research and treatments, connective tissue disorders research, and skin and cellular biology research.

Some of their recent papers include:

  • Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis, 2024, Molecular Aspects of Medicine
  • Dysregulated B cell function and disease pathogenesis in systemic sclerosis, 2023, Frontiers in Immunology
  • Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension, 2021, The International Journal of Biochemistry & Cell Biology
  • The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis, 2021, Arthritis Research & Therapy
  • Single-Cell Analysis of ADSC Interactions with Fibroblasts and Endothelial Cells in Scleroderma Skin, 2023, Cells

Frequent coauthors of David Abraham include:

  • Christopher P. Denton
  • Richard Stratton
  • Bahja Ahmed Abdi
  • Sandra Lopez Garces
  • Voon H Ong

The scientist has commonly published in venues such as:

  • Lara D. Veeken
  • Neurology
  • Arthritis Research & Therapy
  • Cells
  • Nature Reviews Rheumatology

This body of work highlights a multidisciplinary approach within medical research, focusing especially on the mechanisms and clinical aspects of fibrotic and autoimmune conditions affecting connective tissues and the skin.

Best Publications

  • TGF-beta signaling and the fibrotic response.

    Andrew Leask;David J. Abraham

  • Systemic sclerosis: a prototypic multisystem fibrotic disorder.

    John Varga;David Abraham

  • All in the CCN family: essential matricellular signaling modulators emerge from the bunker.

    Andrew Leask;David J. Abraham

  • CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling

    Alan Holmes;David J. Abraham;Susan Sa;Xu Shiwen

  • The Insulin-like Growth Factor I Receptor Protects Tumor Cells from Apoptosis in Vivo

    Mariana Resnicoff;David Abraham;Wiboonchai Yutanawiboonchai;Harris L. Rotman

  • Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

    Xu Shi-Wen;Andrew Leask;David Abraham

  • Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

    Xu Shi-Wen;Yunliang Chen;Christopher P. Denton;Mark Eastwood

  • Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts.

    Andrew Leask;Alan Holmes;Carol M. Black;David J. Abraham

  • Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis

    Annemarie J. van der Slot;Anne-Marie Zuurmond;Alfons F.J. Bardoel;Cisca Wijmenga

  • Scleroderma: from cell and molecular mechanisms to disease models.

    David J. Abraham;John Varga

  • The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology

    Andrew Leask;David J Abraham

  • Tumor Necrosis Factor α Suppresses the Induction of Connective Tissue Growth Factor by Transforming Growth Factor-β in Normal and Scleroderma Fibroblasts

    David J. Abraham;Xu Shiwen;Carol M. Black;Susan Sa

  • Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.

    Xu Shi-wen;Christopher P Denton;Michael R Dashwood;Alan M Holmes

  • Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis.

    Christopher P. Denton;David J. Abraham

  • CTGF expression in mesangial cells: Involvement of SMADs, MAP kinase, and PKC

    Youjun Chen;Ingrid E. Blom;Ingrid E. Blom;Susan Sa;Susan Sa;Roel Goldschmeding;Roel Goldschmeding

  • Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

    Robert B. Good;Adrian J. Gilbane;Sarah L. Trinder;Christopher P. Denton

  • Overview of pathogenesis of systemic sclerosis

    D. J. Abraham;T. Krieg;J. Distler;O. Distler

  • Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis

    Vineeth S Rajkumar;Kevin Howell;Katalin Csiszar;Christopher P Denton

  • Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

    Markella Ponticos;Alan M. Holmes;Xu Shi-Wen;Patricia Leoni

  • Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis

    Andrew Leask;Alan Holmes;David J. Abraham

Frequent Co-Authors

Christopher P. Denton
Christopher P. Denton University College London
Carol M. Black
Carol M. Black University College London
George Bou-Gharios
George Bou-Gharios University of Liverpool
Andrew Leask
Andrew Leask University of Saskatchewan
Thomas J. Nolan
Thomas J. Nolan University of Pennsylvania
Athol U. Wells
Athol U. Wells Imperial College London
Sara Lustigman
Sara Lustigman New York Blood Center
Jeremy D. Pearson
Jeremy D. Pearson King's College London
Gerhard A. Schad
Gerhard A. Schad University of Pennsylvania
Toby M. Maher
Toby M. Maher University of Southern California

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