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Biology and Biochemistry

D-Index
68
Citations
15131
World Ranking
7867
National Ranking
3573

Overview

Carol Feghali-Bostwick is affiliated with the Medical University of South Carolina in the United States. Their research focuses on medical and biochemical fields, particularly within pulmonary and respiratory medicine, pathology and forensic medicine, molecular biology, immunology, and dermatology.

Their work covers several main topics, among which are systemic sclerosis and related diseases, interstitial lung diseases and idiopathic pulmonary fibrosis, connective tissue growth factor research, fibroblast growth factor research, eosinophilic disorders and syndromes, dermatologic treatments and research, and Wnt/β-catenin signaling in development and cancer.

Recent papers authored or co-authored by Carol Feghali-Bostwick include:

  • Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH, 2020, Annals of the Rheumatic Diseases
  • Long noncoding RNA H19X is a key mediator of TGF-β-driven fibrosis, 2020, Journal of Clinical Investigation
  • Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis, 2020, Frontiers in Immunology
  • Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis, 2020, American Journal of Physiology-Lung Cellular and Molecular Physiology
  • Elevated Fibronectin Levels in Profibrotic CD14+ Monocytes and CD14+ Macrophages in Systemic Sclerosis, 2021, Frontiers in Immunology

Frequent co-authors in their publications include:

  • Ludivine Renaud
  • Willian A. da Silveira
  • Joe E. Mouawad
  • DeAnna Baker Frost
  • Xinh-Xinh Nguyen

Carol Feghali-Bostwick has published primarily in several scientific journals, with notable frequency in:

  • International Journal of Molecular Sciences
  • American Journal of Physiology-Lung Cellular and Molecular Physiology
  • Journal of Clinical and Translational Science
  • Frontiers in Immunology
  • Annals of the Rheumatic Diseases

The scope of their scholarly output spans 121 publications in medicine and 35 in biochemistry, genetics, and molecular biology. Their focus on systemic sclerosis and pulmonary fibrosis places them within specialized areas of research involving complex molecular pathways and disease mechanisms.

Best Publications

  • Fibroblasts in fibrosis: novel roles and mediators

    Ryan Thomas Kendall;Carol A. Feghali-Bostwick

  • Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

    Fei Liu;David Lagares;Kyoung Moo Choi;Lauren Stopfer

  • Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

    Zhi Hua Chen;Hong Pyo Kim;Hong Pyo Kim;Frank C. Sciurba;Seon Jin Lee;Seon Jin Lee

  • Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.

    Xiao Mei Wang;Yingze Zhang;Hong Pyo Kim;Zhihong Zhou

  • Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

    Gerald S. Horan;Susan Wood;Victor Ona;Dan Jun Li

  • Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease

    Wen Ning;Chao Jun Li;Chao Jun Li;Naftali Kaminski;Carol A. Feghali-Bostwick

  • Autoantibodies in patients with chronic obstructive pulmonary disease.

    Carol A. Feghali-Bostwick;Aneal S. Gadgil;Leo E. Otterbein;Joseph M. Pilewski

  • Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies.

    Carol Feghali‐Bostwick;Thomas A. Medsger;Timothy M. Wright

  • Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling

    Manu Jain;Stephanie Rivera;Elena A. Monclus;Lauren Synenki

  • Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.

    Swati Bhattacharyya;Kathleen Kelley;Denisa S. Melichian;Zenshiro Tamaki

  • Pulmonary involvement in systemic sclerosis: Associations with genetic, serologic, sociodemographic, and behavioral factors

    Terry A. McNearney;Terry A. McNearney;John D. Reveille;Michael Fischbach;Alan W. Friedman

  • Tenascin-C drives persistence of organ fibrosis.

    Swati Bhattacharyya;Wenxia Wang;Luisa Morales-Nebreda;Gang Feng

  • Insulin-Like Growth Factor Binding Proteins 3 and 5 Are Overexpressed in Idiopathic Pulmonary Fibrosis and Contribute to Extracellular Matrix Deposition

    Joseph M. Pilewski;Lixin Liu;Adam C. Henry;Alycia V. Knauer

  • WNT5A Is a Regulator of Fibroblast Proliferation and Resistance to Apoptosis

    Louis J. Vuga;Ahmi Ben-Yehudah;Elizabetha Kovkarova-Naumovski;Timothy Oriss

  • Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension.

    Eileen Hsu;Haiwen Shi;Rick M. Jordan;James Lyons-Weiler

  • Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension

    Seon Jin Lee;Akaya Smith;Lanping Guo;Tero Pekka Alastalo

  • Review: Interstitial Lung Disease Associated With Systemic Sclerosis and Idiopathic Pulmonary Fibrosis: How Similar and Distinct?

    Erica L. Herzog;Aditi Mathur;Andrew M. Tager;Carol Feghali-Bostwick

  • Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia.

    Imene Boumaza;Suganya Srinivasan;William T. Witt;Carol Feghali-Bostwick

  • PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis.

    Jun Wei;Asish K. Ghosh;Jennifer L. Sargent;Kazuhiro Komura

  • B cell infiltration in systemic sclerosis-associated interstitial lung disease.

    Robert Lafyatis;Carl O'Hara;Carol A. Feghali-Bostwick;Eric Matteson

Frequent Co-Authors

Joseph M. Pilewski
Joseph M. Pilewski University of Pittsburgh
Peter Bradding
Peter Bradding University of Leicester
John Varga
John Varga University of Michigan–Ann Arbor
Augustine M. K. Choi
Augustine M. K. Choi Cornell University
Thomas A. Medsger
Thomas A. Medsger University of Pittsburgh
Oliver Distler
Oliver Distler University of Zurich
Alan J. Knox
Alan J. Knox University of Nottingham
Richard M. Silver
Richard M. Silver Medical University of South Carolina
Naftali Kaminski
Naftali Kaminski Yale University
Robert Lafyatis
Robert Lafyatis University of Pittsburgh

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