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Molecular Biology

D-Index
56
Citations
10337
World Ranking
2210
National Ranking
1095

Overview

Paul R. Andreassen is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, with extensive contributions in Molecular Biology, Genetics, Hematology, Cell Biology, and Oncology.

The scientist's research focuses on several core topics including DNA Repair Mechanisms, CRISPR and Genetic Engineering, BRCA gene mutations in cancer, Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, Acute Myeloid Leukemia Research, and RNA Research and Splicing.

Paul R. Andreassen has authored multiple papers, some of which include:

  • Understanding BRCA2 Function as a Tumor Suppressor Based on Domain-Specific Activities in DNA Damage Responses, 2021, Genes
  • Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis, 2021, Cellular and Molecular Life Sciences
  • The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis, 2020, Current Biology
  • Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation, 2022, Nature Communications
  • Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability, 2023, Nature Communications

Frequent co-authors collaborating with Paul R. Andreassen include:

  • Satoshi H. Namekawa
  • Hironori Abe
  • Kris G. Alavattam
  • Constanze Wiek
  • Helmut Hanenberg

The scientist has published frequently in several venues, notable among them:

  • Nature Communications
  • Human Molecular Genetics
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cellular and Molecular Life Sciences

Best Publications

  • Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.

    Toshiyasu Taniguchi;Irene Garcia-Higuera;Bo Xu;Paul R. Andreassen

  • S-phase–specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51

    Toshiyasu Taniguchi;Irene Garcia-Higuera;Irene Garcia-Higuera;Paul R. Andreassen;Paul R. Andreassen;Richard C. Gregory;Richard C. Gregory

  • ATR couples FANCD2 monoubiquitination to the DNA-damage response

    Paul R. Andreassen;Alan D. D'Andrea;Toshiyasu Taniguchi

  • Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

    Paul R. Andreassen;Olivier D. Lohez;Françoise B. Lacroix;Robert L. Margolis

  • Functional Interaction of Monoubiquitinated FANCD2 and BRCA2/FANCD1 in Chromatin

    XiaoZhe Wang;Paul R. Andreassen;Alan D. D'Andrea

  • BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

    Rachel Litman;Min Peng;Zhe Jin;Fan Zhang

  • PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

    Fan Zhang;Qiang Fan;Keqin Ren;Paul R. Andreassen

  • Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints.

    Dimitrios A. Skoufias;Paul R. Andreassen;Françoise B. Lacroix;Leslie Wilson

  • G1 tetraploidy checkpoint and the suppression of tumorigenesis.

    Robert L. Margolis;Olivier D. Lohez;Paul R. Andreassen

  • Differential Subcellular Localization of Protein Phosphatase-1 α, γ1, and δ Isoforms during Both Interphase and Mitosis in Mammalian Cells

    Paul R. Andreassen;Françoise B. Lacroix;Emma Villa-Moruzzi;Robert L. Margolis

  • Mitogen-activated protein kinase kinase activity is required for the G2/M transition of the cell cycle in mammalian fibroblasts

    Jocelyn H. Wright;Erlynda Munar;Damon R. Jameson;Paul R. Andreassen

  • BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.

    Thiyam Ramsing Singh;Abdullah Mahmood Ali;Valeria Busygina;Steven Raynard

  • MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells

    Yosuke Ichijima;Yosuke Ichijima;Misako Ichijima;Misako Ichijima;Zhenkun Lou;André Nussenzweig

  • Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin.

    Rocio Montes De Oca;Rocio Montes De Oca;Rocio Montes De Oca;Paul R. Andreassen;Paul R. Andreassen;Paul R. Andreassen;Steven P. Margossian;Steven P. Margossian;Steven P. Margossian;Richard C. Gregory;Richard C. Gregory;Richard C. Gregory

  • Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M

    Thiyam Ramsing Singh;Sietske T. Bakker;Sietske T. Bakker;Sheba Agarwal;Michael Jansen

  • CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites

    Rajeswari Jayavaradhan;Devin M. Pillis;Michael Goodman;Fan Zhang

  • Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells.

    P R Andreassen;R L Margolis

  • Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

    Jung-Young Park;Thiyam R. Singh;Nicolas Nassar;Fan Zhang

  • Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis.

    P.R. Andreassen;D.K. Palmer;M.H. Wener;R.L. Margolis

  • The Mammalian Passenger Protein TD-60 Is an RCC1 Family Member with an Essential Role in Prometaphase to Metaphase Progression

    Cristiana Mollinari;Caroline Reynaud;Stephanie Martineau-Thuillier;Solange Monier

Frequent Co-Authors

Helmut Hanenberg
Helmut Hanenberg University of Duisburg-Essen
Robert L. Margolis
Robert L. Margolis Sanford Burnham Prebys Medical Discovery Institute
Stella M. Davies
Stella M. Davies Cincinnati Children's Hospital Medical Center
Punam Malik
Punam Malik Cincinnati Children's Hospital Medical Center
Yi Zheng
Yi Zheng Cincinnati Children's Hospital Medical Center
James C. Mulloy
James C. Mulloy Cincinnati Children's Hospital Medical Center
Amanda E. Toland
Amanda E. Toland The Ohio State University
Susan B. Olson
Susan B. Olson Oregon Health & Science University
Ralph Scully
Ralph Scully Beth Israel Deaconess Medical Center
Fowzan S. Alkuraya
Fowzan S. Alkuraya Alfaisal University

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