His scientific interests lie mostly in DNA repair, Homologous recombination, Molecular biology, DNA and Non-homologous end joining. His study with DNA repair involves better knowledge in Genetics. The Homologous recombination study which covers Cell biology that intersects with DNA replication.
His Molecular biology research integrates issues from RAD51, Poly ADP ribose polymerase and Homology directed repair. His research in Homology directed repair intersects with topics in Double Strand Break Repair and Microhomology-mediated end joining. His research investigates the connection between DNA and topics such as Ubiquitin that intersect with issues in Antephase Checkpoint.
His primary areas of study are DNA repair, Cell biology, Genetics, DNA damage and Homologous recombination. His DNA repair study combines topics in areas such as Molecular biology and Caenorhabditis elegans. His Molecular biology research includes themes of Replication protein A, Homology directed repair, Poly ADP ribose polymerase and Proliferating cell nuclear antigen.
His Cell biology research integrates issues from CHEK1, Suppressor, Genome instability, Telomere and DNA replication. His DNA damage research is multidisciplinary, incorporating elements of Chromatin, G2-M DNA damage checkpoint, Synthetic lethality and Phosphorylation. His Homologous recombination study frequently intersects with other fields, such as Homologous chromosome.
Simon J. Boulton mainly investigates DNA damage, Cell biology, Telomere, DNA repair and DNA replication. In his research, Non-homologous end joining and Protein subunit is intimately related to G2-M DNA damage checkpoint, which falls under the overarching field of DNA damage. The study incorporates disciplines such as Chromatin, Chromosome and Synthetic lethality in addition to Cell biology.
His DNA repair research incorporates elements of PARP inhibitor and Homologous recombination. Genetics covers Simon J. Boulton research in Homologous recombination. His DNA replication research is multidisciplinary, incorporating perspectives in Cellular differentiation, Cancer research, Genome instability and Helicase.
Simon J. Boulton focuses on DNA damage, Cell biology, DNA repair, Telomere and Cancer research. His research integrates issues of Meiosis and Synthetic lethality in his study of DNA damage. The concepts of his Cell biology study are interwoven with issues in Sister chromatids, Chromosome, Synaptonemal complex, Germline and Meiotic chromosome segregation.
His studies deal with areas such as Shelterin, Cyclin-dependent kinase, DNA replication and Helicase as well as DNA repair. His study on Cancer research also encompasses disciplines like
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Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
J. Ross Chapman;Martin R.G. Taylor;Simon J. Boulton.
Molecular Cell (2012)
Double-strand break repair: 53BP1 comes into focus
Stephanie Panier;Simon J. Boulton.
Nature Reviews Molecular Cell Biology (2014)
Components of the Ku‐dependent non‐homologous end‐joining pathway are involved in telomeric length maintenance and telomeric silencing
Simon J. Boulton;Stephen P. Jackson.
The EMBO Journal (1998)
Identification of a Saccharomyces Cerevisiae Ku80 Homologue: Roles in DNA Double Strand Break Rejoining and in Telomeric Maintenance
Simon J. Boulton;Stephen P. Jackson.
Nucleic Acids Research (1996)
RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
J. Ross Chapman;Patricia Barral;Jean-Baptiste Vannier;Valérie Borel.
Molecular Cell (2013)
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
Raphael Ceccaldi;Jessica C. Liu;Ravindra Amunugama;Ildiko Hajdu.
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.
S. J. Boulton;S. P. Jackson.
The EMBO Journal (1996)
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.
Dragana Ahel;Zuzana Hořejší;Nicola Wiechens;Sophie E. Polo.
REV7 counteracts DNA double-strand break resection and affects PARP inhibition
Guotai Xu;J. Ross Chapman;Inger Brandsma;Jingsong Yuan.
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
Ivan Ahel;Dragana Ahel;Takahiro Matsusaka;Allison J. Clark.
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