World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
13655
World Ranking
10254
National Ranking
781

Overview

Ivan Ahel is affiliated with the University of Oxford in the United Kingdom and focuses their research primarily within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine.

The scientific work of Ivan Ahel encompasses significant investigation in several subfields, including Oncology, Molecular Biology, Immunology, Physiology, and Electrical and Electronic Engineering.

The main research topics associated with their work include:

  • PARP inhibition in cancer therapy
  • Toxin Mechanisms and Immunotoxins
  • Calcium signaling and nucleotide metabolism
  • DNA Repair Mechanisms
  • Integrated Circuits and Semiconductor Failure Analysis
  • Ubiquitin and proteasome pathways
  • Electrostatic Discharge in Electronics

Ivan Ahel has published extensively, with a record of frequent appearances in high-impact venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Molecular Cell, Nucleic Acids Research, and The EMBO Journal.

Key recent papers include:

  • ADP-ribosyltransferases, an update on function and nomenclature, 2021, FEBS Journal
  • HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation, 2020, Nature
  • Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking, 2021, Science Advances
  • (ADP-ribosyl)hydrolases: structure, function, and biology, 2020, Genes & Development
  • Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD, 2020, Molecular Cell

The scientist collaborates frequently with a group of recurring coauthors, indicating long-term research partnerships. These frequent collaborators include M. Schuller, J.G.M. Rack, Kang Zhu, Dragana Ahel, and Dmitri V. Filippov.

Best Publications

  • Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.

    Dragana Ahel;Zuzana Hořejší;Nicola Wiechens;Sophie E. Polo

  • The genome of Nanoarchaeum equitans: Insights into early archaeal evolution and derived parasitism

    Elizabeth Waters;Michael J. Hohn;Ivan Ahel;David E. Graham

  • Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

    Ivan Ahel;Dragana Ahel;Takahiro Matsusaka;Allison J. Clark

  • Family-wide analysis of poly(ADP-ribose) polymerase activity

    Sejal Vyas;Ivan Matic;Lilen Uchima;Jenny Rood

  • The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

    Ivan Ahel;Ulrich Rass;Sherif F. El-Khamisy;Sherif F. El-Khamisy;Sachin Katyal

  • The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.

    Dea Slade;Mark S. Dunstan;Eva Barkauskaite;Ria Weston

  • Defective DNA Repair and Neurodegenerative Disease

    Ulrich Rass;Ivan Ahel;Stephen C. West

  • Deficiency of terminal ADP‐ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

    Reza Sharifi;Rosa Morra;C Denise Appel;Michael Tallis

  • Serine ADP-Ribosylation Depends on HPF1

    Juan José Bonfiglio;Pietro Fontana;Qi Zhang;Thomas Colby

  • HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity.

    Ian Gibbs-Seymour;Pietro Fontana;Johannes Gregor Matthias Rack;Ivan Ahel

  • Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation

    Eva Barkauskaite;Gytis Jankevicius;Ivan Ahel

  • Macrodomains: Structure, Function, Evolution, and Catalytic Activities

    Johannes Gregor Matthias Rack;Dragutin Perina;Ivan Ahel

  • Trans-editing of mischarged tRNAs.

    Ivan Ahel;Dragana Korencic;Michael Ibba;Dieter Söll

  • Serine is a new target residue for endogenous ADP-ribosylation on histones

    Orsolya Leidecker;Juan José Bonfiglio;Thomas Colby;Qi Zhang

  • ADP-ribosyltransferases, an update on function and nomenclature

    Bernhard Lüscher;Ivan Ahel;Matthias Altmeyer;Alan Ashworth

  • DNA repair factor APLF is a histone chaperone.

    Pawan Vinod Mehrotra;Dragana Ahel;Daniel P. Ryan;Ria Weston

  • The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection.

    Anthony R. Fehr;Rudragouda Channappanavar;Gytis Jankevicius;Craig Fett

  • Serine is the major residue for ADP-ribosylation upon DNA damage

    Luca Palazzo;Orsolya Leidecker;Evgeniia Prokhorova;Helen Dauben

  • HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation

    Marcin J. Suskiewicz;Florian Zobel;Tom E. H. Ogden;Pietro Fontana

  • Identification of Macrodomain Proteins as Novel O-Acetyl-ADP-ribose Deacetylases

    Dawei Chen;Melanie Vollmar;Marianna N Rossi;Claire Phillips

Frequent Co-Authors

Dieter Söll
Dieter Söll Yale University
Stephen C. West
Stephen C. West The Francis Crick Institute
Marijan Ahel
Marijan Ahel Institut Ruđer Bošković
David Leys
David Leys University of Manchester
Paul J. Hergenrother
Paul J. Hergenrother University of Illinois at Urbana-Champaign
Andreas G. Ladurner
Andreas G. Ladurner Ludwig-Maximilians-Universität München
Michael Ibba
Michael Ibba Chapman University
Ronald T. Hay
Ronald T. Hay University of Dundee
Simon J. Boulton
Simon J. Boulton The Francis Crick Institute
Keith W. Caldecott
Keith W. Caldecott University of Sussex

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Ivan Ahel

Trending Scientists