D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 43 Citations 7,533 378 World Ranking 16700 National Ranking 16

Overview

What is she best known for?

The fields of study she is best known for:

  • Enzyme
  • DNA
  • Gene

Her primary areas of study are Biochemistry, DNA, DNA polymerase, Molecular biology and DNA repair. Her study in AP site, Tyrosyl-DNA Phosphodiesterase 1, DNA polymerase beta, DNA ligase and Polymerase falls under the purview of Biochemistry. Her Tyrosyl-DNA Phosphodiesterase 1 research includes elements of Stereochemistry and Cytotoxicity.

Her DNA polymerase study integrates concerns from other disciplines, such as DNA clamp, DNA polymerase I, DNA polymerase II, Primer and DNA replication. Her research combines Base excision repair and Molecular biology. Her research in DNA repair is mostly focused on Nucleotide excision repair.

Her most cited work include:

  • Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase β and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity (97 citations)
  • Characterization of DNA ADP-ribosyltransferase Activities of PARP2 and PARP3: New Insights Into DNA ADP-ribosylation (57 citations)
  • Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging (53 citations)

What are the main themes of her work throughout her whole career to date?

Olga I. Lavrik spends much of her time researching Biochemistry, DNA, Molecular biology, DNA polymerase and DNA repair. Her research investigates the link between Biochemistry and topics such as Replication protein A that cross with problems in HMG-box and Protein subunit. Her work deals with themes such as Photoaffinity labeling, Biophysics and Cell biology, which intersect with DNA.

Her research integrates issues of Polymerase, Primase, DNA polymerase I, Primer and DNA synthesis in her study of DNA polymerase. Her research brings together the fields of DNA damage and DNA repair. The Base excision repair study combines topics in areas such as Proliferating cell nuclear antigen and AP site.

She most often published in these fields:

  • Biochemistry (65.09%)
  • DNA (53.07%)
  • Molecular biology (38.68%)

What were the highlights of her more recent work (between 2016-2021)?

  • DNA (53.07%)
  • DNA repair (45.28%)
  • Biochemistry (65.09%)

In recent papers she was focusing on the following fields of study:

Olga I. Lavrik mostly deals with DNA, DNA repair, Biochemistry, Tyrosyl-DNA Phosphodiesterase 1 and Phosphodiesterase. In her study, Internalization and Double stranded is strongly linked to Cell biology, which falls under the umbrella field of DNA. Her DNA repair research incorporates elements of Transcription, DNA damage and DNA replication.

Her Tyrosyl-DNA Phosphodiesterase 1 study combines topics in areas such as Covalent bond, Stereochemistry and Topoisomerase-I Inhibitor. Her Phosphodiesterase research incorporates themes from Structure–activity relationship, Topoisomerase, Topotecan and Pharmacology. Her AP site research integrates issues from DNA glycosylase and DNA polymerase.

Between 2016 and 2021, her most popular works were:

  • Characterization of DNA ADP-ribosyltransferase Activities of PARP2 and PARP3: New Insights Into DNA ADP-ribosylation (57 citations)
  • PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA (46 citations)
  • Dna is a New Target of Parp3. (33 citations)

In her most recent research, the most cited papers focused on:

  • Enzyme
  • DNA
  • Gene

Olga I. Lavrik mainly focuses on DNA repair, DNA, Phosphodiesterase, Biochemistry and DNA damage. In general DNA repair, her work in Base excision repair is often linked to Naked mole-rat linking many areas of study. Her work carried out in the field of Base excision repair brings together such families of science as AP site, DNA polymerase and Protein–protein interaction.

As a part of the same scientific family, Olga I. Lavrik mostly works in the field of AP site, focusing on Molecular biology and, on occasion, Uracil and Nucleotide excision repair. DNA is closely attributed to Cell biology in her research. Her study looks at the relationship between Phosphodiesterase and topics such as Topoisomerase, which overlap with Topotecan.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The crystal structure of phenylalanyl-tRNA synthetase from Thermus thermophilus complexed with cognate tRNAPhe

Yehuda Goldgur;Lidia Mosyak;Ludmila Reshetnikova;Valentina Ankilova.
Structure (1997)

302 Citations

DNA Polymerase β-mediated Long Patch Base Excision Repair POLY(ADP-RIBOSE) POLYMERASE-1 STIMULATES STRAND DISPLACEMENT DNA SYNTHESIS

Rajendra Prasad;Olga I. Lavrik;Soon-Jong Kim;Padmini Kedar.
Journal of Biological Chemistry (2001)

258 Citations

Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair.

Olga I. Lavrik;Olga I. Lavrik;Rajendra Prasad;Robert W. Sobol;Julie K. Horton.
Journal of Biological Chemistry (2001)

225 Citations

Human replication protein A unfolds telomeric G-quadruplexes.

Tonatiuh Romero Salas;Irina Petruseva;Olga Lavrik;Anne Bourdoncle.
Nucleic Acids Research (2006)

200 Citations

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins.

Elizaveta E Alemasova;Olga I Lavrik.
Nucleic Acids Research (2019)

193 Citations

HMGB1 is a cofactor in mammalian base excision repair.

Rajendra Prasad;Yuan Liu;Leesa J. Deterding;Vladimir P. Poltoratsky.
Molecular Cell (2007)

174 Citations

Apurinic/apyrimidinic (AP) site recognition by the 5′-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1)

S. N. Khodyreva;R. Prasad;E. S. Ilina;M. V. Sukhanova.
Proceedings of the National Academy of Sciences of the United States of America (2010)

165 Citations

Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase β and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity

Maria V. Sukhanova;Svetlana N. Khodyreva;Natalia A. Lebedeva;Rajendra Prasad.
Nucleic Acids Research (2005)

154 Citations

AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1.

Natalia A. Lebedeva;Nadejda I. Rechkunova;Olga I. Lavrik.
FEBS Letters (2011)

119 Citations

Polarity of human replication protein A binding to DNA

Dmitry M. Kolpashchikov;Svetlana N. Khodyreva;Denis Yu. Khlimankov;Marc S. Wold.
Nucleic Acids Research (2001)

117 Citations

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