World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
49
Citations
9616
World Ranking
14734
National Ranking
54

Biology and Biochemistry

D-Index
52
Citations
10853
World Ranking
16603
National Ranking
17

Overview

Olga I. Lavrik is affiliated with the Russian Academy of Sciences in the Russian Federation. Their research output spans multiple areas within biochemistry, genetics, and molecular biology, with a focus on DNA repair mechanisms and cancer-related topics.

The scientist's recent publications cover detailed aspects of DNA repair and associated molecular processes. Notable papers include:

  • "Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA," published in 2020 in the International Journal of Molecular Sciences
  • "Nucleotide Excision Repair: From Molecular Defects to Neurological Abnormalities," published in 2021 in the International Journal of Molecular Sciences
  • "The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context," published in 2021 in Scientific Reports
  • "PARPs' impact on base excision DNA repair," published in 2020 in DNA Repair
  • "Dual function of HPF1 in the modulation of PARP1 and PARP2 activities," published in 2021 in Communications Biology

Frequent co-authors collaborating with Olga I. Lavrik include:

  • Nadezhda S. Dyrkheeva
  • Нариман Ф. Салахутдинов
  • Alexandra L. Zakharenko
  • Olga A. Luzina
  • Ekaterina S. Ilina

Their work is often published in key scientific venues, notably:

  • International Journal of Molecular Sciences (25 publications)
  • Biochemistry (Moscow) (10 publications)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature (10 publications)
  • Molecules (9 publications)
  • Molecular Biology (7 publications)

The primary fields of study in their research portfolio include biochemistry, genetics, and molecular biology (247 publications), along with medicine (95 publications). Within these disciplines, their subfields of study cover:

  • Molecular Biology (224 publications)
  • Oncology (73 publications)
  • Organic Chemistry (27 publications)
  • Electrical and Electronic Engineering (17 publications)
  • Cancer Research (12 publications)

Olga I. Lavrik's main research topics focus on:

  • DNA Repair Mechanisms (112 publications)
  • PARP inhibition in cancer therapy (106 publications)
  • Cancer therapeutics and mechanisms (98 publications)
  • CRISPR and Genetic Engineering (36 publications)
  • RNA Research and Splicing (28 publications)
  • DNA and Nucleic Acid Chemistry (24 publications)
  • Synthesis and bioactivity of alkaloids (22 publications)

Best Publications

  • Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins.

    Elizaveta E Alemasova;Olga I Lavrik

  • The crystal structure of phenylalanyl-tRNA synthetase from Thermus thermophilus complexed with cognate tRNAPhe

    Yehuda Goldgur;Lidia Mosyak;Ludmila Reshetnikova;Valentina Ankilova

  • DNA Polymerase β-mediated Long Patch Base Excision Repair POLY(ADP-RIBOSE) POLYMERASE-1 STIMULATES STRAND DISPLACEMENT DNA SYNTHESIS

    Rajendra Prasad;Olga I. Lavrik;Soon-Jong Kim;Padmini Kedar

  • Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair.

    Olga I. Lavrik;Olga I. Lavrik;Rajendra Prasad;Robert W. Sobol;Julie K. Horton

  • PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA

    Anastasia S. Singatulina;Loic Hamon;Maria V. Sukhanova;Bénédicte Desforges

  • Human replication protein A unfolds telomeric G-quadruplexes.

    Tonatiuh Romero Salas;Irina Petruseva;Olga Lavrik;Anne Bourdoncle

  • HMGB1 is a cofactor in mammalian base excision repair.

    Rajendra Prasad;Yuan Liu;Leesa J. Deterding;Vladimir P. Poltoratsky

  • Apurinic/apyrimidinic (AP) site recognition by the 5′-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1)

    S. N. Khodyreva;R. Prasad;E. S. Ilina;M. V. Sukhanova

  • Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase β and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity

    Maria V. Sukhanova;Svetlana N. Khodyreva;Natalia A. Lebedeva;Rajendra Prasad

  • Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.

    Ibtissam Talhaoui;Natalia A. Lebedeva;Gabriella Zarkovic;Christine Saint-Pierre

  • Polarity of human replication protein A binding to DNA

    Dmitry M. Kolpashchikov;Svetlana N. Khodyreva;Denis Yu. Khlimankov;Marc S. Wold

  • Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging

    Maria V. Sukhanova;Sanae Abrakhi;Vandana Joshi;David Pastre

  • AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1.

    Natalia A. Lebedeva;Nadejda I. Rechkunova;Olga I. Lavrik

  • XRCC1 interactions with base excision repair DNA intermediates.

    Zhanna K. Nazarkina;Svetlana N. Khodyreva;Stéphanie Marsin;Olga I. Lavrik

  • Characterization of DNA ADP-ribosyltransferase Activities of PARP2 and PARP3: New Insights Into DNA ADP-ribosylation

    Gabriella Zarkovic;Ekaterina A Belousova;Ibtissam Talhaoui;Christine Saint-Pierre

  • AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate.

    Cheryl Cistulli;Olga I Lavrik;Olga I Lavrik;Rajendra Prasad;Esther Hou

  • Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety.

    Alexandra Zakharenko;Tatyana Khomenko;Tatyana Khomenko;Svetlana Zhukova;Olga Koval;Olga Koval

  • Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in DNA Repair.

    A. A. Kosova;S. N. Khodyreva;S. N. Khodyreva;O. I. Lavrik;O. I. Lavrik

  • Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue.

    Ludmila Reshetnikova;Nina Moor;Olga Lavrik;Dmitry G. Vassylyev

  • Molecular mechanism of global genome nucleotide excision repair.

    I. O. Petruseva;A. N. Evdokimov;O. I. Lavrik

  • Localization of xeroderma pigmentosum group A protein and replication protein A on damaged DNA in nucleotide excision repair

    Yuliya S. Krasikova;Nadejda I. Rechkunova;Ekaterina A. Maltseva;Irina O. Petruseva

  • Poly(ADP-ribose) polymerase 1 regulates activity of DNA polymerase β in long patch base excision repair

    Maria Sukhanova;Svetlana Khodyreva;Olga Lavrik

Frequent Co-Authors

Rajendra Prasad
Rajendra Prasad Amity University
Lev L. Kisselev
Lev L. Kisselev Engelhardt Institute of Molecular Biology
Serge Boiteux
Serge Boiteux Centre national de la recherche scientifique, CNRS
Samuel H. Wilson
Samuel H. Wilson National Institutes of Health
Marc S. Wold
Marc S. Wold University of Iowa
Valérie Schreiber
Valérie Schreiber Institute of Genetics and Molecular and Cellular Biology
Orlando D. Schärer
Orlando D. Schärer Institute for Basic Science
Samuel H. Wilson
Samuel H. Wilson Research Triangle Park Foundation
Alexey A. Popov
Alexey A. Popov Leibniz Association
Elena I. Frolova
Elena I. Frolova University of Alabama at Birmingham

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a degree in Chemistry can open doors to a variety of rewarding careers, many of which are available through online programs. One such path is becoming a pharmaceutical sales representative, a role with competitive compensation — understanding the pharmaceutical rep salary can help you gauge potential earnings in this field.

For those interested in healthcare and clinical applications of chemistry, becoming a pharmacist is a viable goal. It’s important to consider how long does it take to become a pharmacist, as this profession requires substantial education and training but rewards with strong job stability and salary.

Chemistry graduates may also explore careers in forensic science or medical examination, such as working as an autopsy technician. Learning about the autopsy technician role, including educational requirements and job outlook, can help clarify this unique pathway.

Additionally, some chemistry-related roles may require foundational education levels, like an associate's degree, which can influence earning potential — researching paralegal salary associate's degree offers insight into how degree types affect pay, even outside the immediate chemistry field.

Best Scientists Citing Olga I. Lavrik

Trending Scientists