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Biology and Biochemistry

D-Index
62
Citations
14314
World Ranking
10757
National Ranking
4672

Overview

Robert W. Sobol is affiliated with the University of South Alabama in the United States and works primarily within the fields of Biochemistry, Genetics, and Molecular Biology as well as Medicine. Their research output includes nearly a hundred publications focused mostly on Molecular Biology and Oncology, with marked contributions to Cancer Research, Immunology, and Epidemiology.

The scientist's work centers around understanding DNA repair mechanisms and their application in cancer therapy. Their research topics include:

  • DNA Repair Mechanisms
  • PARP inhibition in cancer therapy
  • CRISPR and Genetic Engineering
  • Carcinogens and Genotoxicity Assessment
  • Cancer Genomics and Diagnostics
  • Toxin Mechanisms and Immunotoxins
  • Cytomegalovirus and herpesvirus research

Robert W. Sobol's recent papers include:

  • Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity (2020, Scientific Reports)
  • Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis (2021, Cell Reports)
  • Protein lipoylation: mitochondria, cuproptosis, and beyond (2024, Trends in Biochemical Sciences)
  • Regulation of ALT-associated homology-directed repair by polyADP-ribosylation (2020, Nature Structural & Molecular Biology)
  • SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity (2021, Nature Communications)

The scientist has frequently published in several key venues which include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • DNA repair
  • Environmental and Molecular Mutagenesis
  • Cancer Research
  • Journal of Clinical and Translational Science

Collaborations have been established with a number of coauthors, reflecting interdisciplinary research efforts. Frequent coauthors include:

  • Christopher A. Koczor
  • Joel Andrews
  • Jennifer Clark
  • Kate M. Saville
  • Jianfeng Li

In addition to journal publications, Robert W. Sobol has a book publication with Frontiers Media titled Mechanistic Studies of Genome Integrity, Environmental Health, and Cancer Etiology published in 2022.

Best Publications

  • Requirement of mammalian DNA polymerase-beta in base-excision repair.

    Robert W. Sobol;Julie K. Horton;Ralf Kühn;Hua Gu

  • Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.

    Ping Mao;Kaushal Joshi;Jianfeng Li;Sung Hak Kim

  • A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.

    Karen H. Almeida;Robert W. Sobol

  • Mutation research/fundamental and molecular mechanisms of mutagenesis: special issue: DNA repair and genetic instability.

    Kandace Williams;Robert W Sobol

  • The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity

    Robert W. Sobol;Rajendra Prasad;Andrea Evenski;Audrey Baker

  • Up-Regulation of Dicer, a Component of the MicroRNA Machinery, in Prostate Adenocarcinoma

    Simion Chiosea;Elena Jelezcova;Uma Chandran;Marie Acquafondata

  • Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage

    David Svilar;Eva M. Goellner;Karen H. Almeida;Robert W. Sobol

  • Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells.

    Paola Fortini;Barbara Pascucci;Eleonora Parlanti;Robert W. Sobol

  • Overexpression of Dicer in precursor lesions of lung adenocarcinoma.

    Simion Chiosea;Elena Jelezcova;Uma Chandran;Jianhua Luo

  • The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death.

    Ram N. Trivedi;Karen H. Almeida;Jamie L. Fornsaglio;Sandra Schamus

  • Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Daniel T. Shaughnessy;Kimberly McAllister;Leroy Worth;Astrid C. Haugen

  • Impairment of Proliferating Cell Nuclear Antigen-dependent Apurinic/Apyrimidinic Site Repair on Linear DNA

    Siham Biade;Robert W. Sobol;Samuel H. Wilson;Yoshihiro Matsumoto

  • Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair.

    Olga I. Lavrik;Olga I. Lavrik;Rajendra Prasad;Robert W. Sobol;Julie K. Horton

  • MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.

    Kaushal Joshi;Yeshavanth Banasavadi-Siddegowda;Xiaokui Mo;Sung-Hak Kim

  • Base Excision Repair Intermediates Induce p53-independent Cytotoxic and Genotoxic Responses

    Robert W. Sobol;Maria Kartalou;Karen H. Almeida;Donna F. Joyce

  • Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1

    Ryo Ueda;Gary Kohanbash;Kotaro Sasaki;Mitsugu Fujita

  • ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD + depletion

    Elise Fouquerel;Eva M. Goellner;Zhongxun Yu;Zhongxun Yu;Jean-Philippe Gagné

  • Upregulation of the 2-5A Synthetase/RNase L Antiviral Pathway Associated with Chronic Fatigue Syndrome

    Robert J. Suhadolnik;Nancy L. Reichenbach;Patricia Hitzges;Robert W. Sobol

  • IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group

    Ian F. Pollack;Ronald L. Hamilton;Robert W. Sobol;Marina N. Nikiforova

  • Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase.

    W. E. G. Muller;B. E. Weiler;R. Charubala;W. Pfleiderer

Frequent Co-Authors

Samuel H. Wilson
Samuel H. Wilson National Institutes of Health
Wolfgang Pfleiderer
Wolfgang Pfleiderer University of Konstanz
Bennett Van Houten
Bennett Van Houten University of Pittsburgh
Trey Ideker
Trey Ideker University of California, San Diego
Rajendra Prasad
Rajendra Prasad Amity University
Ian F. Pollack
Ian F. Pollack University of Pittsburgh
Ichiro Nakano
Ichiro Nakano University of Alabama at Birmingham
Ronald L. Hamilton
Ronald L. Hamilton University of Pittsburgh
Lionel Larue
Lionel Larue University of Paris-Saclay
Alfonso Bellacosa
Alfonso Bellacosa Fox Chase Cancer Center

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