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Neuroscience
Ireland
2026

D-Index & Metrics

Neuroscience

D-Index
72
Citations
16784
World Ranking
2325
National Ranking
6

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Ireland Leader Award
  • 2025 - Research.com Neuroscience in Ireland Leader Award
  • 2023 - Research.com Neuroscience in Ireland Leader Award
  • 2022 - Research.com Neuroscience in Ireland Leader Award

Overview

David C. Henshall is affiliated with the Royal College of Surgeons in Ireland. Their research spans several interconnected fields, primarily focusing on biochemistry, genetics, molecular biology, and medicine. Within these areas, their work addresses key subfields including molecular biology, cancer research, genetics, cellular and molecular neuroscience, and psychiatry and mental health.

Their scholarly contributions emphasize important research topics such as microRNA in disease regulation, neuroscience and neuropharmacology, epilepsy research and treatment, genetics and neurodevelopmental disorders, adenosine and purinergic signaling, circular RNAs in diseases, and RNA interference and gene delivery.

David C. Henshall's recent publications include:

  • LifeTime and improving European healthcare through cell-based interceptive medicine, 2020, Nature
  • MicroRNAs as regulators of brain function and targets for treatment of epilepsy, 2020, Nature Reviews Neurology
  • Microvascular stabilization via blood-brain barrier regulation prevents seizure activity, 2022, Nature Communications
  • Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap, 2021, Nature Reviews Neurology
  • Climate change and epilepsy: Insights from clinical and basic science studies, 2021, Epilepsy & Behavior

The scientist frequently collaborates with other researchers. Notable coauthors include Tobías Engel, Gary P. Brennan, Cristina R. Reschke, Norman Delanty, and Amaya Sanz-Rodriguez, each contributing to multiple joint publications.

David C. Henshall has published extensively in certain venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Epilepsia
  • Scientific Reports
  • Nature Reviews Neurology
  • British Journal of Pharmacology

Best Publications

  • Increased hippocampal neurogenesis in Alzheimer's disease

    Kunlin Jin;Alyson L. Peel;Xiao Ou Mao;Lin Xie

  • Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

    Eva M Jimenez-Mateos;Tobias Engel;Paula Merino-Serrais;Ross C McKiernan

  • To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways

    Anthony K.F Liou;Robert S Clark;David C Henshall;Xiao-Ming Yin

  • Epilepsy and apoptosis pathways.

    David C Henshall;Roger P Simon

  • Activation of Bcl-2-Associated Death Protein and Counter-Response of Akt within Cell Populations during Seizure-Induced Neuronal Death

    David C. Henshall;Tomohiro Araki;Clara K. Schindler;Jing-Quan Lan

  • Endotoxin Preconditioning Prevents Cellular Inflammatory Response During Ischemic Neuroprotection in Mice

    Holly L. Rosenzweig;Nikola S. Lessov;David C. Henshall;Manabu Minami

  • Neuroprotective Actions of FK506 in Experimental Stroke: In Vivo Evidence against an Antiexcitotoxic Mechanism

    Steven P. Butcher;David C. Henshall;Yoshinori Teramura;Kazuhide Iwasaki

  • MicroRNAs in epilepsy: pathophysiology and clinical utility

    David C Henshall;Hajo M Hamer;R Jeroen Pasterkamp;David B Goldstein

  • CREB-mediated Bcl-2 protein expression after ischemic preconditioning.

    Robert Meller;Manabu Minami;Jennifer A. Cameron;Soren Impey

  • miRNA Expression Profile after Status Epilepticus and Hippocampal Neuroprotection by Targeting miR-132

    Eva M. Jimenez-Mateos;Isabella Bray;Amaya Sanz-Rodriguez;Tobias Engel

  • Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.

    David C. Henshall;Jun Chen;Roger P. Simon

  • Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

    Tobias Engel;Rosa Gomez-Villafuertes;Rosa Gomez-Villafuertes;Katsuhiro Tanaka;Guillaume Mesuret

  • Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy

    D.C. Henshall;R.S. B. Clark;P.D. Adelson;M. Chen

  • Neuroinflammatory targets and treatments for epilepsy validated in experimental models

    Eleonora Aronica;Sebastian Bauer;Yuri Bozzi;Yuri Bozzi;Matteo Caleo

  • Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

    Unknown

  • Endotoxin Preconditioning Protects against the Cytotoxic Effects of TNFα after Stroke: A Novel Role for TNFα in LPS-Ischemic Tolerance:

    Holly L Rosenzweig;Manabu Minami;Nikola S Lessov;Sarah C Coste

  • Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

    Alba Jimenez-Pacheco;Guillaume Mesuret;Amaya Sanz-Rodriguez;Katsuhiro Tanaka

  • Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy

    Suzanne F.C. Miller-Delaney;Kenneth Bryan;Sudipto Das;Ross C. McKiernan

  • Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

    Alba Jimenez-Pacheco;Miguel Diaz-Hernandez;Marina Arribas-Blázquez;Amaya Sanz-Rodriguez

  • Induction of Oxidative DNA Damage in the Peri-Infarct Region After Permanent Focal Cerebral Ischemia

    Tetsuya Nagayama;Jing Lan;David C. Henshall;Dexi Chen

  • Apoptosis signalling pathways in seizure-induced neuronal death and epilepsy.

    D.C. Henshall

  • MicroRNA and epilepsy: profiling, functions and potential clinical applications.

    David C. Henshall

Frequent Co-Authors

Tobias Engel
Tobias Engel Royal College of Surgeons in Ireland
Roger P. Simon
Roger P. Simon Morehouse School of Medicine
Felix Rosenow
Felix Rosenow Goethe University Frankfurt
Norman Delanty
Norman Delanty Beaumont Hospital
Raymond L. Stallings
Raymond L. Stallings Royal College of Surgeons in Ireland
Stephanie Schorge
Stephanie Schorge University College London
John L. Waddington
John L. Waddington Royal College of Surgeons in Ireland
Yuri Bozzi
Yuri Bozzi University of Trento
Michele Simonato
Michele Simonato University of Ferrara
Hajo M. Hamer
Hajo M. Hamer University of Erlangen-Nuremberg

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