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Biology and Biochemistry
Ireland
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
32541
World Ranking
2528
National Ranking
13

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Ireland Leader Award
  • 2022 - Research.com Biology and Biochemistry in Ireland Leader Award

Overview

Jochen H. M. Prehn is affiliated with the Royal College of Surgeons in Ireland. Their research spans diverse areas within medicine and biochemistry, genetics, and molecular biology, with significant contributions in molecular biology and oncology.

The scientist has authored multiple papers on a range of topics related to cancer and cellular biology. Some of their recent publications include:

  • Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy (2022, Annals of Oncology)
  • Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain (2022, American Journal of Physiology-Cell Physiology)
  • New hints towards a precision medicine strategy for IDH wild-type glioblastoma (2020, Annals of Oncology)
  • tRNA-derived fragments: A new class of non-coding RNA with key roles in nervous system function and dysfunction (2021, Progress in Neurobiology)
  • Precision Therapy in RAS Mutant Colorectal Cancer (2020, Gastroenterology)

Frequent co-authors who have collaborated extensively with Prehn include:

  • Manuela Salvucci
  • John P. Burke
  • Heiko Düßmann
  • Annette T. Byrne
  • Daniel B. Longley

Prehn has published notably in these venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Cancer Research
  • Scientific Reports
  • Frontiers in Cell and Developmental Biology

Their primary fields of study include medicine and biochemistry, genetics, and molecular biology, with substantial scholarly activity in molecular biology, oncology, cancer research, genetics, and neurology.

Main topics covered in their work include:

  • Colorectal Cancer Treatments and Studies
  • Genetic factors in colorectal cancer
  • Glioma Diagnosis and Treatment
  • Cancer Immunotherapy and Biomarkers
  • Mitochondrial Function and Pathology
  • Cancer Genomics and Diagnostics
  • RNA modifications and cancer

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • S100B in brain damage and neurodegeneration

    Matthias Rothermundt;Marion Peters;Jochen H.M. Prehn;Volker Arolt

  • ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

    Matthew J Greenway;Peter M Andersen;Carsten Russ;Sean Ennis

  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    L. Galluzzi;L. Galluzzi;L. Galluzzi;S. A. Aaronson;J. Abrams;E. S. Alnemri

  • Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome

    Lorna Flanagan;Jasmin Schmid;Matthias Ebert;Pavel Soucek

  • Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway.

    Claus Reimertz;Donat Kögel;Abdelhaq Rami;Thomas Chittenden

  • Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

    Markus Rehm;Heiko Dussmann;Reiner U Janicke;Jeremy M Tavare

  • TGF-β1 Protects Hippocampal Neurons Against Degeneration Caused by Transient Global Ischemia: Dose-Response Relationship and Potential Neuroprotective Mechanisms

    P. Henrich-Noack;J.H.M. Prehn;J. Krieglstein

  • Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death.

    Silke Lankiewicz;C. Marc Luetjens;Nguyen Truc Bui;Aaron J. Krohn

  • Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons

    Jochen H. M. Prehn;Vytautas P. Bindokas;Charles J. Marcuccilli;Stanislaw Krajewski

  • Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production.

    C. Marc Luetjens;Nguyen Truc Bui;Bernd Sengpiel;Gudrun Münstermann

  • Transforming Growth Factor-β1 Prevents Glutamate Neurotoxicity in Rat Neocortical Cultures and Protects Mouse Neocortex from Ischemic Injury in vivo

    Jochen H. M. Prehn;Cord Backhauß;Josef Krieglstein

  • MicroRNAs in epilepsy: pathophysiology and clinical utility

    David C Henshall;Hajo M Hamer;R Jeroen Pasterkamp;David B Goldstein

  • Systems analysis of effector caspase activation and its control by X‐linked inhibitor of apoptosis protein

    Markus Rehm;Heinrich J Huber;Heiko Dussmann;Jochen H M Prehn

  • Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

    Aaron J. Krohn;Elke Preis;Jochen H. M. Prehn

  • p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

    Joaquı́n Jordán;Marı́a F. Galindo;Jochen H. M. Prehn;Ralph R. Weichselbaum

  • Mitochondrial Depolarization Is Not Required for Neuronal Apoptosis

    Aaron J. Krohn;Tanja Wahlbrink;Jochen H. M. Prehn

  • Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer

    Daniele Bano;Jochen H.M. Prehn

  • Control of motoneuron survival by angiogenin.

    Dairín Kieran;Jordi Sebastia;Matthew J. Greenway;Matthew A. King

Frequent Co-Authors

David C. Henshall
David C. Henshall Royal College of Surgeons in Ireland
Donat Kögel
Donat Kögel Goethe University Frankfurt
Tobias Engel
Tobias Engel Royal College of Surgeons in Ireland
Bryan T. Hennessy
Bryan T. Hennessy Beaumont Hospital
Josef Krieglstein
Josef Krieglstein University of Münster
Felix Rosenow
Felix Rosenow Goethe University Frankfurt
Joaquín Jordán
Joaquín Jordán University of Castilla-La Mancha
Oliver Kepp
Oliver Kepp Institut Gustave Roussy
Bauke Ylstra
Bauke Ylstra Vrije Universiteit Amsterdam

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