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Neuroscience

D-Index
48
Citations
7296
World Ranking
6254
National Ranking
25

Overview

Tobias Engel is affiliated with the Royal College of Surgeons in Ireland in Ireland. Their research spans various domains within biochemistry, genetics, molecular biology, and medicine, with a total of 93 publications in these main fields.

Their work engages deeply with several subfields, specifically physiology, molecular biology, psychiatry and mental health, genetics, and cancer research. Tobias Engel's topics of focus include:

  • Adenosine and Purinergic Signaling
  • Genetics and Neurodevelopmental Disorders
  • Epilepsy research and treatment
  • Neuroscience and Neuropharmacology Research
  • MicroRNA in disease regulation
  • Neurological Complications and Syndromes
  • Neuroscience of respiration and sleep

Their recent papers cover important themes such as epilepsy, inflammation, and microRNA-mediated mechanisms:

  • "ATP and adenosine-Two players in the control of seizures and epilepsy development," 2021, Progress in Neurobiology
  • "Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases," 2021, International Journal of Molecular Sciences
  • "A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy," 2020, Proceedings of the National Academy of Sciences
  • "Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy," 2020, Neurobiology of Disease
  • "Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse," 2020, Neuroscience Bulletin

Tobias Engel has frequently collaborated with other researchers in their field. The most frequent co-authors include David C. Henshall, Mariana Alves, Giorgia Conte, Laura de Diego-García, and Annette Nicke.

The scholar has contributed publications regularly to a range of journals and platforms. The most common venues for their work include:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Epilepsia
  • Frontiers in Molecular Neuroscience
  • British Journal of Pharmacology

In addition to journal articles, Tobias Engel has authored a book titled "The molecular mechanisms of epilepsy and potential therapeutics," published by Frontiers Media in 2022.

Best Publications

  • Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

    Eva M Jimenez-Mateos;Tobias Engel;Paula Merino-Serrais;Ross C McKiernan

  • Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.

    Claudie Hooper;V Markevich;Florian Plattner;Richard Killick

  • Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

    Tobias Engel;Félix Hernández;Jesús Ávila;José Javier Lucas

  • miRNA Expression Profile after Status Epilepticus and Hippocampal Neuroprotection by Targeting miR-132

    Eva M. Jimenez-Mateos;Isabella Bray;Amaya Sanz-Rodriguez;Tobias Engel

  • Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

    Tobias Engel;Rosa Gomez-Villafuertes;Rosa Gomez-Villafuertes;Katsuhiro Tanaka;Guillaume Mesuret

  • Chronic lithium administration to FTDP-17 tau and GSK-3β overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert

    Tobias Engel;Paloma Goñi-Oliver;José Javier Lucas;Jesús Ávila

  • Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.

    Karina Kaczmarek-Hajek;Jiong Zhang;Jiong Zhang;Robin Kopp;Antje Grosche;Antje Grosche

  • Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

    Alba Jimenez-Pacheco;Guillaume Mesuret;Amaya Sanz-Rodriguez;Katsuhiro Tanaka

  • Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

    Alba Jimenez-Pacheco;Miguel Diaz-Hernandez;Marina Arribas-Blázquez;Amaya Sanz-Rodriguez

  • MicroRNAs in Neurodegenerative Diseases

    Sean Quinlan;Aidan Kenny;Miguel Medina;Tobias Engel

  • Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice

    Genshin Mouri;Eva Jimenez-Mateos;Tobias Engel;Mark Dunleavy

  • Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis.

    Ross C McKiernan;Eva M Jimenez-Mateos;Isabella Bray;Tobias Engel

  • Cooexpression of FTDP-17 tau and GSK-3β in transgenic mice induce tau polymerization and neurodegeneration

    Tobias Engel;José Javier Lucas;Pilar Gómez-Ramos;María A. Morán

  • Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis?

    Tobias Engel;David C Henshall

  • ATPergic signalling during seizures and epilepsy.

    Tobias Engel;Mariana Alves;Caroline Sheedy;David C. Henshall

  • Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus

    Eva M. Jimenez-Mateos;Tobias Engel;Paula Merino-Serrais;Isabel Fernaud-Espinosa

  • The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy.

    Edward Beamer;Wolfgang Fischer;Tobias Engel

  • MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset

    Christina Gross;Christina Gross;Christina Gross;Xiaodi Yao;Tobias Engel;Durgesh Tiwari

  • microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

    Eva M. Jimenez-Mateos;Marina Arribas-Blazquez;Amaya Sanz-Rodriguez;Caoimhin Concannon

  • Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer’s disease

    Aidan Kenny;Eva María Jiménez-Mateos;María Ascensión Zea-Sevilla;Alberto Rábano

  • CHOP regulates the p53–MDM2 axis and is required for neuronal survival after seizures

    Tobias Engel;Amaya Sanz-Rodgriguez;Eva M. Jimenez-Mateos;Caoimhin G. Concannon

  • In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury

    Tobias Engel;Nikolaus Plesnila;Jochen H M Prehn;David C Henshall

Frequent Co-Authors

David C. Henshall
David C. Henshall Royal College of Surgeons in Ireland
Norman Delanty
Norman Delanty Beaumont Hospital
Felix Rosenow
Felix Rosenow Goethe University Frankfurt
Raymond L. Stallings
Raymond L. Stallings Royal College of Surgeons in Ireland
Stephanie Schorge
Stephanie Schorge University College London
Roger P. Simon
Roger P. Simon Morehouse School of Medicine
Nicholas Dale
Nicholas Dale University of Warwick
Steve C. Danzer
Steve C. Danzer Cincinnati Children's Hospital Medical Center
Detlev Boison
Detlev Boison Rutgers, The State University of New Jersey
Jan M. Deussing
Jan M. Deussing Max Planck Society

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