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Biology and Biochemistry

D-Index
60
Citations
15172
World Ranking
11826
National Ranking
234

Overview

José J. Lucas is affiliated with the Spanish National Research Council in Spain. Their research focuses predominantly on molecular biology and neuroscience, with over 60 publications in biochemistry, genetics, and molecular biology, as well as 21 publications in neuroscience.

The main subfields of their work include molecular biology, cellular and molecular neuroscience, neurology, genetics, and psychiatry and mental health. Their research topics cover genetic neurodegenerative diseases, RNA research and splicing, mitochondrial function and pathology, RNA regulation and disease, neuroscience and neuropharmacology research, RNA and protein synthesis mechanisms, and bipolar disorder and treatment.

Notable recent papers authored or coauthored by José J. Lucas include:

  • Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD, 2024, Nature
  • Huntington's disease-specific mis-splicing unveils key effector genes and altered splicing factors, 2021, Brain
  • A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease, 2021, Acta Neuropathologica
  • High concordance between hippocampal transcriptome of the mouse intra-amygdala kainic acid model and human temporal lobe epilepsy, 2020, Epilepsia
  • P2X7 Receptor Upregulation in Huntington's Disease Brains, 2020, Frontiers in Molecular Neuroscience

Frequent coauthors with whom José J. Lucas has collaborated include:

  • Ivó H. Hernández
  • María Santos-Galindo
  • Sara Picó
  • Ainara Elorza
  • Alberto Parras

José J. Lucas has published regularly in several academic venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain
  • Epilepsia
  • Acta Neuropathologica Communications
  • European Neuropsychopharmacology

Best Publications

  • Role of tau protein in both physiological and pathological conditions.

    Jesús Ávila;José Javier Lucas;Mar Pérez;Félix Hernández

  • Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice

    José Javier Lucas;José Javier Lucas;Félix Hernández;Félix Hernández;Pilar Gómez-Ramos;María A. Morán

  • Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418

    Ratan Bhat;Yafeng Xue;Stefan Berg;Sven Hellberg

  • Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.

    Claudie Hooper;V Markevich;Florian Plattner;Richard Killick

  • Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments.

    Félix Hernández;José Borrell;Carmen Guaza;Jesús Avila

  • GSK3 and tau: two convergence points in Alzheimer's disease.

    Felix Hernandez;Jose J. Lucas;Jesus Avila

  • GSK3: a possible link between beta amyloid peptide and tau protein.

    Félix Hernández;Elena Gómez de Barreda;Almudena Fuster-Matanzo;José J. Lucas

  • Neuronal induction of the immunoproteasome in Huntington's disease

    Miguel Díaz-Hernández;Félix Hernández;Ester Martín-Aparicio;Pilar Gómez-Ramos

  • Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

    Tobias Engel;Félix Hernández;Jesús Ávila;José Javier Lucas

  • Huntington's disease is a four-repeat tauopathy with tau nuclear rods

    Marta Fernández-Nogales;Jorge Rubén Cabrera;María Santos-Galindo;Jeroen J. M. Hoozemans

  • Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

    Miguel Díaz-Hernández;Miguel Díaz-Hernández;María Díez-Zaera;Jesús Sánchez-Nogueiro;Jesús Sánchez-Nogueiro;Rosa Gómez-Villafuertes

  • FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain

    Filip Lim;Félix Hernández;José Javier Lucas;Pilar Gómez-Ramos

  • In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

    Juan Ignacio Diaz-Hernandez;Juan Ignacio Diaz-Hernandez;Juan Ignacio Diaz-Hernandez;Rosa Gomez-Villafuertes;Rosa Gomez-Villafuertes;Rosa Gomez-Villafuertes;Miriam León-Otegui;Miriam León-Otegui;Lourdes Hontecillas-Prieto

  • Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease

    Cristina Blázquez;Anna Chiarlone;Onintza Sagredo;Tania Aguado

  • Chronic lithium administration to FTDP-17 tau and GSK-3β overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert

    Tobias Engel;Paloma Goñi-Oliver;José Javier Lucas;Jesús Ávila

  • Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options

    A. C. Ludolph;J. Kassubek;B. G. Landwehrmeyer;E. Mandelkow

  • Proteasomal-Dependent Aggregate Reversal and Absence of Cell Death in a Conditional Mouse Model of Huntington's Disease

    Ester Martín-Aparicio;Ai Yamamoto;Félix Hernández;René Hen

  • Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome

    Karina Hernández-Ortega;Paula Garcia-Esparcia;Laura Gil;José J. Lucas

  • Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.

    Félix Hernández;Mar Pérez;José Javier Lucas;Ana M. Mata

  • Absence of Fenfluramine-Induced Anorexia and Reduced c-fos Induction in the Hypothalamus and Central Amygdaloid Complex of Serotonin 1B Receptor Knock-Out Mice

    José J. Lucas;Ai Yamamoto;Kimberly Scearce-Levie;Frédéric Saudou

Frequent Co-Authors

Jesús Avila
Jesús Avila Centro de Biología Molecular Severo Ochoa
Félix Hernández
Félix Hernández Jaume I University
Miguel Díaz-Hernández
Miguel Díaz-Hernández Complutense University of Madrid
Tobias Engel
Tobias Engel Royal College of Surgeons in Ireland
Jordi Alberch
Jordi Alberch University of Barcelona
David C. Henshall
David C. Henshall Royal College of Surgeons in Ireland
Isidro Ferrer
Isidro Ferrer University of Barcelona
Josep M. Canals
Josep M. Canals University of Barcelona
Esther Pérez-Navarro
Esther Pérez-Navarro University of Barcelona
María Teresa Miras-Portugal
María Teresa Miras-Portugal Complutense University of Madrid

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