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Josep M. Canals

Josep M. Canals

D-Index & Metrics

Neuroscience

D-Index
44
Citations
7868
World Ranking
7147
National Ranking
115

Overview

Josep M. Canals is affiliated with the University of Barcelona in Spain. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. Within these broad areas, Canals has focused notably on Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Oncology, and Genetics.

The scientist's research topics are diverse, including Pluripotent Stem Cells Research, Genetic Neurodegenerative Diseases, CAR-T Cell Therapy Research, Neuroinflammation and Neurodegeneration Mechanisms, Tryptophan and Brain Disorders, Virus-based Gene Therapy Research, and Viral Infectious Diseases and Gene Expression in Insects.

Frequent publication venues where Josep M. Canals has contributed include Frontiers in Cellular Neuroscience, Research Square, bioRxiv, Molecular Neurobiology, and arXiv. These outlets reflect interdisciplinary work across cellular neuroscience, molecular biology, and preprint platforms.

Their recent papers highlight a focus on both translational and cellular neuroscience, as well as immunotherapy approaches. Notable publications include:

  • CART19-BE-01: A Multicenter Trial of ARI-0001 Cell Therapy in Patients with CD19+ Relapsed/Refractory Malignancies (2020, Molecular Therapy)
  • Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial (2020, Frontiers in Immunology)
  • Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington's Disease (2020, Frontiers in Cellular Neuroscience)
  • Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation (2020, Molecular Neurobiology)
  • Is the Immunological Response a Bottleneck for Cell Therapy in Neurodegenerative Diseases? (2020, Frontiers in Cellular Neuroscience)

Josep M. Canals has collaborated frequently with several researchers in related fields. Co-authors with the highest counts of joint publications include Jordi Alberch, Manel Juan, Albert Giralt, Unai Perpiñá, and Julio Delgado.

Best Publications

  • Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

    Adriana Sánchez‐Danés;Yvonne Richaud‐Patin;Iria Carballo‐Carbajal;Senda Jiménez‐Delgado

  • Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes.

    Joseph Wagner;Peter Åkerud;Diogo S. Castro;Pontus C. Holm

  • Neuroprotection through Delivery of Glial Cell Line-Derived Neurotrophic Factor by Neural Stem Cells in a Mouse Model of Parkinson's Disease

    Peter Åkerud;Josep M. Canals;Evan Y. Snyder;Ernest Arenas

  • Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor.

    Philippe Naveilhan;Hessameh Hassani;Josep M. Canals;A. Jonas Ekstrand

  • Brain-Derived Neurotrophic Factor Regulates the Onset and Severity of Motor Dysfunction Associated with Enkephalinergic Neuronal Degeneration in Huntington's Disease

    Josep M. Canals;José R. Pineda;Jesús F. Torres-Peraza;Miquel Bosch

  • Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

    Miguel Díaz-Hernández;Miguel Díaz-Hernández;María Díez-Zaera;Jesús Sánchez-Nogueiro;Jesús Sánchez-Nogueiro;Rosa Gómez-Villafuertes

  • Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

    Maria Borrell-Pagès;Josep M. Canals;Fabrice P. Cordelières;J. Alex Parker

  • Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

    Ryan G Lim;Lisa L Salazar;Daniel K Wilton;Alvin R King

  • Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

    Daniel del Toro;Jordi Alberch;Francisco Lázaro-Diéguez;Raquel Martín-Ibáñez

  • Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation

    Andrés Miguez;Gerardo García-Díaz Barriga;Verónica Brito;Marco Straccia

  • Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

    Silvia Ginés;Miquel Bosch;Sonia Marco;Núria Gavaldà

  • Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease

    J Alberch;E Pérez-Navarro;J.M Canals

  • Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients

    Rubén Fernández‐Santiago;Iria Carballo‐Carbajal;Giancarlo Castellano;Roger Torrent

  • CART19-BE-01: A Multicenter Trial of ARI-0001 Cell Therapy in Patients with CD19+ Relapsed/Refractory Malignancies

    Valentín Ortíz-Maldonado;Susana Rives;Maria Castellà;Anna Alonso-Saladrigues

  • Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: Involvement of phospholipaseCγ activity and glutamate receptor expression

    A. Giralt;T. Rodrigo;E.D. Martín;J.R. Gonzalez

  • Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.

    Josep M. Canals;Núria Checa;Sònia Marco;Peter Åkerud

  • Neurotrophic factors in Huntington's disease.

    Jordi Alberch;Esther Pérez-Navarro;Josep M Canals

  • Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease.

    Miquel Bosch;José R. Pineda;Cristina Suñol;Jordi Petriz

  • BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.

    A Giralt;H C Friedman;B Caneda-Ferrón;N Urbán

  • Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions

    Maria Castella;Anna Boronat;Raquel Martín-Ibáñez;Vanina Rodríguez

  • Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

    Ryan G Lim;Lisa L Salazar;Daniel K Wilton

Frequent Co-Authors

Jordi Alberch
Jordi Alberch University of Barcelona
Esther Pérez-Navarro
Esther Pérez-Navarro University of Barcelona
Anne Elizabeth Rosser
Anne Elizabeth Rosser Cardiff University
Patrik Ernfors
Patrik Ernfors Karolinska Institute
Andrew D. Randall
Andrew D. Randall University of Exeter
Steven A. Goldman
Steven A. Goldman University of Rochester Medical Center
Emmanuel Brouillet
Emmanuel Brouillet Centre national de la recherche scientifique, CNRS
Guadalupe Mengod
Guadalupe Mengod Spanish National Research Council
Marcy E. MacDonald
Marcy E. MacDonald Harvard University
James F. Gusella
James F. Gusella Harvard University

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