World's Best Scientists 2026 revealed!
Frédéric Saudou

Frédéric Saudou

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
22588
World Ranking
8074
National Ranking
271

Research.com Recognitions

  • 2014 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for his major contributions to the understanding of molecular and cellular mechanisms causing Huntington's disease.

Overview

Frédéric Saudou is affiliated with Grenoble Alpes University in France and has made contributions primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Neuroscience. Their research encompasses molecular and cellular aspects of neurodegenerative diseases, with a significant focus on Huntington's disease and related neurological disorders.

The scientist's recent publications highlight various dimensions of neuroscience and molecular biology. Notable papers include:

  • Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing (2020, Nature Reviews Drug Discovery)
  • Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice (2021, Science Advances)
  • Traffic signaling: new functions of huntingtin and axonal transport in neurological disease (2020, Current Opinion in Neurobiology)
  • Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity (2020, Nature Communications)
  • Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin (2020, Cell Reports)

The scientist has collaborated frequently with several researchers, including Sandrine Humbert, Chiara Scaramuzzino, Hélène Vitet, Julie Bruyère, and Sophie Lenoir, indicating active involvement in collaborative projects often centered on neurological and molecular biology research.

Prominent venues where the scientist has published multiple papers include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Nature Communications
  • Cell Reports
  • eLife

Frédéric Saudou's major subfields of study consist of Molecular Biology, Cellular and Molecular Neuroscience, Cell Biology, Neurology, and Physiology. The topical focus of their work spans several key areas:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Neuroscience and Neuropharmacology Research
  • Cellular transport and secretion
  • Neurogenesis and neuroplasticity mechanisms
  • Ubiquitin and proteasome pathways
  • Neurological disorders and treatments

In 2014, Saudou received the Richard Lounsbery Award jointly from the National Academy of Sciences and the French Academy of Sciences for significant research related to the molecular and cellular mechanisms underlying Huntington's disease.

Best Publications

  • Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

    Frédéric Saudou;Steven Finkbeiner;Steven Finkbeiner;Didier Devys;Michael E Greenberg;Michael E Greenberg

  • Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules

    Laurent R Gauthier;Bénédicte C Charrin;Maria Borrell-Pagès;Jim P Dompierre

  • Enhanced aggressive behavior in mice lacking 5-HT1B receptor

    Frédéric Saudou;Djamel Aït Amara;Andrée Dierich;Marianne LeMeur

  • Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

    Georges Imbert;Frédéric Saudou;Frédéric Saudou;Gaël Yvert;Gaël Yvert;Didier Devys;Didier Devys

  • Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

    Gilles David;Nacer Abbas;Giovanni Stevanin;Alexandra Dürr

  • The Biology of Huntingtin

    Frédéric Saudou;Frédéric Saudou;Sandrine Humbert;Sandrine Humbert

  • Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation

    Jim P. Dompierre;Juliette D. Godin;Bénédicte C. Charrin;Fabrice P. Cordelières

  • Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

    Stephen C. Cunnane;Eugenia Trushina;Cecilie Morland;Alessandro Prigione

  • Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

    Yvon Trottier;Yves Lutz;Giovanni Stevanin;Georges Imbert

  • The IGF-1/Akt Pathway Is Neuroprotective in Huntington's Disease and Involves Huntingtin Phosphorylation by Akt

    Sandrine Humbert;Elzbieta A. Bryson;Fabrice P. Cordelières;Nathan C. Connors

  • Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form.

    Yvon Trottier;Didier Devys;Georges Imbert;Frédéric Saudou

  • Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

    Diana Zala;Maria-Victoria Hinckelmann;Maria-Victoria Hinckelmann;Maria-Victoria Hinckelmann;Hua Yu;Hua Yu;Hua Yu;Marcel Menezes Lyra da Cunha;Marcel Menezes Lyra da Cunha

  • Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

    Emilie Colin;Diana Zala;Diana Zala;Géraldine Liot;Géraldine Liot;Hélène Rangone;Hélène Rangone

  • A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns.

    F. Saudou;U. Boschert;N. Amlaiky;J.L. Plassat

  • Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis

    Juliette D. Godin;Kelly Colombo;Kelly Colombo;Kelly Colombo;Maria Molina-Calavita;Maria Molina-Calavita;Maria Molina-Calavita;Guy Keryer;Guy Keryer;Guy Keryer

  • Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

    Alison E. Twelvetrees;Eunice Y. Yuen;I. Lorena Arancibia-Carcamo;Andrew F. MacAskill

  • Potential function for the Huntingtin protein as a scaffold for selective autophagy.

    Joseph Ochaba;Tamás Lukacsovich;George Csikos;Shuqiu Zheng

  • Fos Family Members Induce Cell Cycle Entry by Activating Cyclin D1

    Jennifer R. Brown;Jennifer R. Brown;Elizabeth Nigh;Elizabeth Nigh;Richard J. Lee;Hong Ye;Hong Ye

  • Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

    M Borrell-Pagès;M Borrell-Pagès;D Zala;S Humbert;F Saudou

  • Cloning and characterization of a Drosophila tyramine receptor.

    F. Saudou;N. Amlaiky;J. L. Plassat;E. Borrelli

Frequent Co-Authors

Sandrine Humbert
Sandrine Humbert Grenoble Alpes University
Alexis Brice
Alexis Brice Institut du Cerveau
Jean-Louis Mandel
Jean-Louis Mandel Institute of Genetics and Molecular and Cellular Biology
Giovanni Stevanin
Giovanni Stevanin Inserm : Institut national de la santé et de la recherche médicale
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Alexandra Durr
Alexandra Durr Sorbonne University
Laurent Villard
Laurent Villard Aix-Marseille University
Nicole Déglon
Nicole Déglon University of Lausanne
Yves Agid
Yves Agid Institut du Cerveau
Laurent Nguyen
Laurent Nguyen University of Liège

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry opens the door to a wide range of online degrees and rewarding career options in health and science. For those interested in nutritional sciences, best dietetics masters programs can provide advanced training and prepare you for credentials as a Registered Dietitian.

Those looking for a faster route into healthcare roles may consider medical assistant classes online with financial aid. These programs are increasingly popular for students who value flexible study and assistance with tuition costs.

If you’re already working as a medical assistant, you might be ready to take the next step. Bridge programs such as ma to lpn bridge programs online accelerate your path toward becoming a Licensed Practical Nurse, often through fully online study.

For a broad foundation, online options like bs in biology online allow you to earn a bachelor’s degree flexibly, preparing you for diverse roles or further studies in science, research, and medicine. These pathways can help you build a career that fits your interests and lifestyle.

Best Scientists Citing Frédéric Saudou

Trending Scientists

Recently Published Articles