World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
49
Citations
9324
World Ranking
2630
National Ranking
67

Overview

Alfred C. O. Vertegaal is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a publication record indicating significant contributions to Molecular Biology, Oncology, Genetics, Immunology, and Cell Biology.

Their work covers various main topics including:

  • Ubiquitin and proteasome pathways
  • DNA Repair Mechanisms
  • RNA modifications and cancer
  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Protein Degradation and Inhibitors
  • Peptidase Inhibition and Analysis

Vertegaal has coauthored frequently with several collaborators, highlighting active collaborative research efforts. Notable frequent co-authors include:

  • Román González-Prieto
  • Martijn S. Luijsterburg
  • Yana van der Weegen
  • Fredrik Trulsson
  • Joachim Goedhart

The scientist has published extensively in well-recognized venues. Among the most frequent are:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Cell Reports
  • The Journal of Experimental Medicine

Selected recent papers by Alfred C. O. Vertegaal include:

  • "Signalling mechanisms and cellular functions of SUMO" (2022, Nature Reviews Molecular Cell Biology)

Although not the primary author, related notable works from frequent collaborators include:

  • "The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II" (2020, Nature Communications)
  • "Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model" (2022, Gut)
  • "Targeting SUMO Signaling to Wrestle Cancer" (2020, Trends in cancer)
  • "ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation" (2021, Nature Cell Biology)

Best Publications

  • Uncovering global SUMOylation signaling networks in a site-specific manner

    Ivo A Hendriks;Rochelle C J D'Souza;Bing Yang;Matty Verlaan-de Vries

  • A comprehensive compilation of SUMO proteomics

    Ivo A. Hendriks;Ivo A. Hendriks;Alfred C. O. Vertegaal

  • Distinct and Overlapping Sets of SUMO-1 and SUMO-2 Target Proteins Revealed by Quantitative Proteomics

    Alfred C.O. Vertegaal;Jens S. Andersen;Stephen C. Ogg;Ronald T. Hay

  • In Vivo Identification of Human Small Ubiquitin-like Modifier Polymerization Sites by High Accuracy Mass Spectrometry and an in Vitro to in Vivo Strategy

    Ivan Matic;Martijn van Hagen;Joost Schimmel;Boris Macek

  • Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

    Ivo A Hendriks;David Lyon;Clifford Young;Lars J Jensen

  • Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

    Ivan Matic;Joost Schimmel;Ivor .A. Hendriks;Maria A. van Santen

  • A proteomic study of SUMO-2 target proteins.

    Alfred C.O. Vertegaal;Stephen C. Ogg;Ellis Jaffray;Manuel S. Rodriguez

  • IκBα is a target for the mitogen‐activated 90 kDa ribosomal S6 kinase

    Govert J. Schouten;Alfred C. O. Vertegaal;Simon T. Whiteside;Alain Israël

  • SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer

    Karolin Eifler;Alfred C.O. Vertegaal

  • PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining

    Martijn S. Luijsterburg;Inge de Krijger;Wouter W. Wiegant;Rashmi G. Shah

  • Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein.

    Joost Schimmel;Karolin Eifler;Jón Otti Sigurðsson;Sabine A.G. Cuijpers

  • The Ubiquitin-Proteasome System Is a Key Component of the SUMO-2/3 Cycle

    Joost Schimmel;Katja M. Larsen;Ivan Matic;Martijn van Hagen

  • SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.

    Ivo A. Hendriks;Louise W. Treffers;Matty Verlaan-de Vries;Jesper V. Olsen

  • A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

    Monique P.C. Mulder;Katharina Witting;Ilana Berlin;Jonathan N. Pruneda

  • The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

    Yana van der Weegen;Hadar Golan-Berman;Tycho E. T. Mevissen;Katja Apelt

  • RNF4 is required for DNA double-strand break repair in vivo

    Rajesh Vyas;R Kumar;Frédéric Clermont;A Helfricht

  • The N and C Termini of the Splice Variants of the Human Mitogen-Activated Protein Kinase-Interacting Kinase Mnk2 Determine Activity and Localization

    Gert C. Scheper;Josep L. Parra;Mary Wilson;Barbara van Kollenburg

  • System-wide identification of wild-type SUMO-2 conjugation sites

    Ivo A. Hendriks;Rochelle C. D'Souza;Jer-Gung Chang;Matthias Mann

  • The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity.

    Arjan Buijs;Luc van Rompaey;Anco C. Molijn;J. Nathan Davis

  • Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells.

    Vertegaal Ac;Kuiperij Hb;Yamaoka S;Courtois G

Frequent Co-Authors

Huib Ovaa
Huib Ovaa Leiden University Medical Center
Matthias Mann
Matthias Mann Max Planck Institute of Biochemistry
Haico van Attikum
Haico van Attikum Leiden University Medical Center
Jesper V. Olsen
Jesper V. Olsen University of Copenhagen
Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
Jens S. Andersen
Jens S. Andersen University of Southern Denmark
Johannes C. Walter
Johannes C. Walter Harvard University
Angus I. Lamond
Angus I. Lamond University of Dundee
Ronald T. Hay
Ronald T. Hay University of Dundee
Mats Ljungman
Mats Ljungman University of Michigan–Ann Arbor

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Molecular Biology can open doors to diverse careers beyond traditional lab work. Many students blend their science backgrounds with fields such as psychology, mental health, or even social work—areas where molecular knowledge is increasingly valuable.

If you’re interested in understanding behavior and mental processes at a deeper level, consider an online masters in psychology. For those aiming to work directly in mental health services, a fast track mental health counseling degree can help you quickly enter the field.

Bio-scientific expertise is also in demand in areas like forensic investigation. If this intrigues you, learn what can i do with a masters in forensic psychology to discover pathways where science meets law.

Those wanting to make a community impact may find social work masters programs online valuable, particularly in roles that combine health, advocacy, and molecular biology insights.

Best Scientists Citing Alfred C. O. Vertegaal

Trending Scientists