Frauke Melchior focuses on Biochemistry, SUMO enzymes, SUMO protein, Cell biology and Ubiquitin ligase. Her studies in Biochemistry integrate themes in fields like RANBP2, Nuclear protein, Ubiquitin-conjugating enzyme and SUMO-1 Protein. Her research integrates issues of DDB1 and Protein–protein interaction in her study of RANBP2.
She has researched Nuclear protein in several fields, including Ran and Nuclear transport. The SUMO enzymes study which covers Sumoylation Pathway that intersects with Small Ubiquitin-Related Modifier Proteins. The Protein sumoylation, SUMO2 and SUMO binding research she does as part of her general SUMO protein study is frequently linked to other disciplines of science, such as Histone deacetylase activity, therefore creating a link between diverse domains of science.
The scientist’s investigation covers issues in SUMO protein, Cell biology, Biochemistry, SUMO enzymes and RANBP2. Her work deals with themes such as Molecular biology and Lysine, which intersect with SUMO protein. Her studies link Ubiquitin ligase with Cell biology.
Her study in Biochemistry is interdisciplinary in nature, drawing from both Nuclear protein and Consensus site. Her SUMO enzymes research integrates issues from Sumoylation Pathway, SUMO binding, Bioinformatics and Ubiquitin-activating enzyme. Her work in RANBP2 addresses issues such as RanGAP, which are connected to fields such as Computational biology.
Her scientific interests lie mostly in Cell biology, SUMO protein, Pyrophosphate, Proteome and Signal transduction. Her work on Proteasome as part of general Cell biology research is often related to Basal body, thus linking different fields of science. The study incorporates disciplines such as Lysine and Phosphorylation in addition to SUMO protein.
Her Signal transduction research is multidisciplinary, incorporating elements of Hypoxia, Repressor, Epidermal growth factor receptor and SUMO2. Metabolism is a subfield of Biochemistry that Frauke Melchior explores. Particularly relevant to Yeast is her body of work in Biochemistry.
Cell biology, SUMO protein, Proteasome, SUMO2 and In vitro are her primary areas of study. Frauke Melchior interconnects Innate immune system and Cysteine in the investigation of issues within Cell biology. Her Innate immune system research includes elements of Chemokine and Cytokine.
Frauke Melchior combines subjects such as Oxidative stress, Isopeptide bond, Lysine and Cell signaling with her study of Cysteine. The SUMO2 study combines topics in areas such as Proteome, Hypoxia, Transcriptional regulation and Signal transduction. Her In vitro study integrates concerns from other disciplines, such as HEK 293 cells, Crosstalk, Promyelocytic leukemia protein and Enzyme.
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Concepts in sumoylation: a decade on
Ruth Geiss-Friedlander;Frauke Melchior.
Nature Reviews Molecular Cell Biology (2007)
A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2
Rohit Mahajan;Christian Delphin;Tinglu Guan;Larry Gerace.
The nucleoporin RanBP2 has SUMO1 E3 ligase activity
Andrea Pichler;Andreas Gast;Jacob S. Seeler;Anne Dejean.
Annual Review of Cell and Developmental Biology (2000)
Sumoylation: A Regulatory Protein Modification in Health and Disease
Annette Flotho;Frauke Melchior.
Annual Review of Biochemistry (2013)
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor.
Frauke Melchior;Bryce Paschal;Janice Evans;Larry Gerace.
Journal of Cell Biology (1993)
PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
Shrikesh Sachdev;Laurakay Bruhn;Heidemarie Sieber;Andrea Pichler.
Genes & Development (2001)
Nuclear Pore Complex Structure and Dynamics Revealed by Cryoelectron Tomography
Martin Beck;Friedrich Förster;Mary Ecke;Jürgen M. Plitzko.
SUMO: ligases, isopeptidases and nuclear pores.
Frauke Melchior;Marion Schergaut;Andrea Pichler.
Trends in Biochemical Sciences (2003)
Structure determination of the small ubiquitin-related modifier SUMO-1.
Peter Bayer;Andreas Arndt;Susanne Metzger;Rohit Mahajan.
Journal of Molecular Biology (1998)
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